A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection

International Journal of Cancer

Volumn 93, Issue 2, 2001, Pages 243-251

  Jonuleit, Helmut ^a   Giesecke Tuettenberg, Andrea ^a   Tüting, Thomas ^b   Thurner Schuler, Beatrice ^c   Stuge, Tor B ^a   Paragnik, Lydia ^b   Kandemir, Ayten ^c   Lee, Peter P ^a   Schuler, Gerold ^b   Knop, Jürgen ^c   Enk, Alexander H ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dendritic cells; Immunotherapy; Melanoma; T cell response; Vaccination

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; IMMUNOGLOBULIN E; MONOPHENOL MONOOXYGENASE; VACCINE;

ADULT; AGED; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER ADJUVANT THERAPY; CELL MATURATION; CLINICAL ARTICLE; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOTHERAPY; MALE; MELANOMA; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ANTIGENS, NEOPLASM; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; HUMANS; IMMUNIZATION; INTERFERON TYPE II; LYMPH NODES; MELANOMA; NEOPLASM PROTEINS; NEOPLASM STAGING; PEPTIDES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0035879893     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.1323     Document Type: Article

References (31)

1. + helper T cells
2. Dendritic cells and the control of immunity
3. Origin, maturation and antigen presenting function of dendritic cells
4. Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity
5. Induction of antitumor immunity using bone marrow-generated dendritic cells
6. Therapy of murine tumors with tumor peptide-pulsed dendritic cells: Dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines
7. Genetically modified bone marrow-derived dendritic cells expressing tumor-associated viral or "self" antigens induce antitumor immunity in vivo
8. Dendritic cells as adjuvants for immune-mediated resistance to tumors
9. Rapid generation of broad T cell immunity in humans after a single injection of mature dendritic cells
10. Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma
11. Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application
12. + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha
13. + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophage colony-stimulating factor plus tumor necrosis factor alpha: II. Functional analysis
14. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood
15. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions
16. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
17. Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability
18. + T lymphocytes secreting tumor necrosis factor alpha in response to HLA-A2.1-binding melanoma and viral peptide antigens
19. Phenotypic analysis of antigen-specific T lymphocytes
20. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients
21. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells
22. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells
23. Idiotypic protein-pulsed adherent peripheral blood mononuclear cell-derived dendritic cells prime immune system in multiple myeloma
24. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
25. High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals
26. + melanoma patients by mature monocyte-derived dendritic cells
27. Immature dendritic cells acquire CD8(+) cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or -dependent stimuli
28. Induction of tumor peptide-specific cytotoxic T cells under serum-free conditions by mature human dendritic cells
29. Presence of IgE antibodies to bovine serum albumin in a patient developing anaphylaxis after vaccination with human peptide-pulsed dendritic cells
30. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
31. Dendritic cells as mediators of tumor-induced tolerance in metastatic melanoma