-
1
-
-
0028036933
-
Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumour necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma interferon gene or admixed with conventional adjuvants
-
ALLIONE, A., CONSALVO, M., NANNI, P., LOLLINI, P.L., CAVALLO, F., GIOVARELLI, M., FORNI, M., GULINO, A., COLOMBO, M.P., DALLABONA, P., HOCK, H., BLANKENSTEIN, T., ROSENTHAL, F.M., GANSBACHER, B., BOSCO, M.C., MUSSO, T., GUSELLA, L., and FORNI, G. (1994). Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumour necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma interferon gene or admixed with conventional adjuvants. Cancer Res. 54, 6022-6026.
-
(1994)
Cancer Res.
, vol.54
, pp. 6022-6026
-
-
Allione, A.1
Consalvo, M.2
Nanni, P.3
Lollini, P.L.4
Cavallo, F.5
Giovarelli, M.6
Forni, M.7
Gulino, A.8
Colombo, M.P.9
Dallabona, P.10
Hock, H.11
Blankenstein, T.12
Rosenthal, F.M.13
Gansbacher, B.14
Bosco, M.C.15
Musso, T.16
Gusella, L.17
Forni, G.18
-
2
-
-
0027537310
-
Analysis of the relationship between stage of differentiation and NK/LAK susceptibility of colon carcinoma cells
-
BLOTTIERE, H.M., ZENNADI, R., GREGOIRE, M., AILLET, G., DENIS, M.G., MEFLAH, K., and LE PENDU, J. (1993). Analysis of the relationship between stage of differentiation and NK/LAK susceptibility of colon carcinoma cells. Int. J. Cancer 53, 409-417.
-
(1993)
Int. J. Cancer
, vol.53
, pp. 409-417
-
-
Blottiere, H.M.1
Zennadi, R.2
Gregoire, M.3
Aillet, G.4
Denis, M.G.5
Meflah, K.6
Le Pendu, J.7
-
3
-
-
16944365192
-
A genetically inactivated herpes simplex virus type 2 (HSV-2) vaccine provides effective protection against primary and recurrent HSV-2 disease
-
BOURSNELL, M.E.G., ENTWISLE, C., BLAKELEY, D., ROBERTS, C., DUNCAN, I.A., CHISHOLM, S.E., MARTIN, G.M., JENNINGS, R., NI CHALLNAIN, D., SOBEK, I., INGLIS, S.C., and McLEAN, C.S. (1997). A genetically inactivated herpes simplex virus type 2 (HSV-2) vaccine provides effective protection against primary and recurrent HSV-2 disease. J. Infect. Dis. 175, 16-25.
-
(1997)
J. Infect. Dis.
, vol.175
, pp. 16-25
-
-
Boursnell, M.E.G.1
Entwisle, C.2
Blakeley, D.3
Roberts, C.4
Duncan, I.A.5
Chisholm, S.E.6
Martin, G.M.7
Jennings, R.8
Ni Challnain, D.9
Sobek, I.10
Inglis, S.C.11
McLean, C.S.12
-
4
-
-
0018875598
-
Establishment of mouse colonic embryonic carcinoma cell lines with different metastatic properties
-
BRATTAIN, M.G., STROBEL-STEVENS, J., FINE, D., WEBB, M., and SARRIF, A.M. (1980). Establishment of mouse colonic embryonic carcinoma cell lines with different metastatic properties. Cancer Res. 40, 2142-2146.
-
(1980)
Cancer Res.
, vol.40
, pp. 2142-2146
-
-
Brattain, M.G.1
Strobel-Stevens, J.2
Fine, D.3
Webb, M.4
Sarrif, A.M.5
-
5
-
-
0031581176
-
A family of bicistronic vectors to enhance both local and systemic anti tumour effects of HSVtk or cytokine expression in a murine melanoma model
-
CASTLEDEN, S.A., CHONG, H., GARCIA-RIBAS, I., MELCHER, A.A., HUTCHINSON, G., ROBERTS, B., HART, I.R., and VILE, R.G. (1997). A family of bicistronic vectors to enhance both local and systemic anti tumour effects of HSVtk or cytokine expression in a murine melanoma model. Hum. Gene Ther. 8, 2087-2102.
-
(1997)
Hum. Gene Ther.
, vol.8
, pp. 2087-2102
-
-
Castleden, S.A.1
Chong, H.2
Garcia-Ribas, I.3
Melcher, A.A.4
Hutchinson, G.5
Roberts, B.6
Hart, I.R.7
Vile, R.G.8
-
6
-
-
0031885545
-
Tumour cell expression of B7 costimulatory molecules and interleukin-12 or granulocyte-macrophage colony-stimulating factor induces a local antitumour response and may generate systemic protective immunity
-
CHONG, H., TODRYK, S., HUTCHINSON, G., HART, I.R., and VILE, R.G. (1998). Tumour cell expression of B7 costimulatory molecules and interleukin-12 or granulocyte-macrophage colony-stimulating factor induces a local antitumour response and may generate systemic protective immunity. Gene Ther. 5, 223-232.
-
(1998)
Gene Ther.
, vol.5
, pp. 223-232
-
-
Chong, H.1
Todryk, S.2
Hutchinson, G.3
Hart, I.R.4
Vile, R.G.5
-
7
-
-
0026806362
-
Local cytokine availability elicits tumor rejection and systemic immunity through granulocyte-T-lymphocyte cross-talk
-
COLOMBO, M.P., MODESTI, A., PARMIANI, G., and FORNI, G. (1992). Local cytokine availability elicits tumor rejection and systemic immunity through granulocyte-T-lymphocyte cross-talk. Cancer Res. 52, 4853-5857.
-
(1992)
Cancer Res.
, vol.52
, pp. 4853-5857
-
-
Colombo, M.P.1
Modesti, A.2
Parmiani, G.3
Forni, G.4
-
8
-
-
0031851606
-
Rapid adenoviral transduction of freshly resected tumour explants with therapeutically useful genes provides a rationale for genetic immunotherapy for colorectal cancer
-
DIAZ, R.M., TODRYK, S., CHONG, H., HART, I.R., SIKORA, K., DORUDI, S., and VILE, R.G. (1998). Rapid adenoviral transduction of freshly resected tumour explants with therapeutically useful genes provides a rationale for genetic immunotherapy for colorectal cancer. Gene Ther. 5, 869-879.
-
(1998)
Gene Ther.
, vol.5
, pp. 869-879
-
-
Diaz, R.M.1
Todryk, S.2
Chong, H.3
Hart, I.R.4
Sikora, K.5
Dorudi, S.6
Vile, R.G.7
-
9
-
-
0026457973
-
The influence of tumor lymphocytic infiltration on long term survival of surgically treated colorectal cancer patients
-
DIGIORGIO, A., BOTTI, C., TOCCHI, A., MINGAZZINI, P., and FLAMMIA, M. (1992). The influence of tumor lymphocytic infiltration on long term survival of surgically treated colorectal cancer patients. Int. Surg. 77, 256-260.
-
(1992)
Int. Surg.
, vol.77
, pp. 256-260
-
-
DiGiorgio, A.1
Botti, C.2
Tocchi, A.3
Mingazzini, P.4
Flammia, M.5
-
10
-
-
0031019747
-
A novel herpes vector for the high-efficiency transduction of normal and malignant human haemopoietic cells
-
DILLOO, D., RILL, DL, ENTWISTLE, C., BOURSNELL, M., ZHONG, W., HOLDEN, W., HOLLADAY, M., INGLIS, S., and BRENNER, M. (1997). A novel herpes vector for the high-efficiency transduction of normal and malignant human haemopoietic cells. Blood 89, 119-127.
-
(1997)
Blood
, vol.89
, pp. 119-127
-
-
Dilloo, D.1
Rill, D.L.2
Entwistle, C.3
Boursnell, M.4
Zhong, W.5
Holden, W.6
Holladay, M.7
Inglis, S.8
Brenner, M.9
-
11
-
-
0027538181
-
Vaccination with irradiated tumor cells engineered to secrete murine GM-CSF stimulates potent, specific and long-lasting anti-tumor immunity
-
DRANOFF, G., JAFFEE, E.M., LAZENBY, A., GOLUMBEK, P., LEVITSKY, H., BROSE, K., JACKSON, V., HIROFUMI, H., PARDOLL, D., and MULLIGAN, R.C. (1993). Vaccination with irradiated tumor cells engineered to secrete murine GM-CSF stimulates potent, specific and long-lasting anti-tumor immunity. Proc. Natl. Acad. Sci. U.S.A. 90, 3539-3543.
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 3539-3543
-
-
Dranoff, G.1
Jaffee, E.M.2
Lazenby, A.3
Golumbek, P.4
Levitsky, H.5
Brose, K.6
Jackson, V.7
Hirofumi, H.8
Pardoll, D.9
Mulligan, R.C.10
-
12
-
-
0028934910
-
CDS+ T cells from a patient with colon carcinoma, specific fora mutant p21-ras-derived peptide (Gly13-Asp), are cytotoxic towards a carcinoma cell line harbouring the same mutation
-
FOSSUM, B., OLSEN, A.C., THORSBY, E., and GAUDERNACK, G. (1995). CDS+ T cells from a patient with colon carcinoma, specific fora mutant p21-ras-derived peptide (Gly13-Asp), are cytotoxic towards a carcinoma cell line harbouring the same mutation. Cancer Immunol. Immunother. 40, 165-172.
-
(1995)
Cancer Immunol. Immunother.
, vol.40
, pp. 165-172
-
-
Fossum, B.1
Olsen, A.C.2
Thorsby, E.3
Gaudernack, G.4
-
13
-
-
0027483695
-
The "bystander effect": Tumor regression when a fraction of the tumor mass is genetically modified
-
FREEMAN, S.M., ABBOUD, C.N., WHARTENBY, K.A., PACKMAN, C.H., KOEPLIN, D.S., MOOLTEN, F.L., and ABRAHAM, G.N. (1993). The "bystander effect": Tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res. 53, 5274-5283.
-
(1993)
Cancer Res.
, vol.53
, pp. 5274-5283
-
-
Freeman, S.M.1
Abboud, C.N.2
Whartenby, K.A.3
Packman, C.H.4
Koeplin, D.S.5
Moolten, F.L.6
Abraham, G.N.7
-
14
-
-
0027015406
-
Clinical protocol: A pilot study of immunization with HLA-A2 matched allogeneic melanoma cells that secrete interleukin-2 in patients with metastatic melanoma
-
GANSBACHER, B., HOUGHTON, A., LIVINGSTON, P., MINASIAN, L., ROSENTHAL, F., GILBOA, E., GOLDE, D., OETTGEN, H., STEFFANS, T., YANG, S.Y., and WONG, G. (1992). Clinical protocol: A pilot study of immunization with HLA-A2 matched allogeneic melanoma cells that secrete interleukin-2 in patients with metastatic melanoma. Hum. Gene Ther. 3, 677-690.
-
(1992)
Hum. Gene Ther.
, vol.3
, pp. 677-690
-
-
Gansbacher, B.1
Houghton, A.2
Livingston, P.3
Minasian, L.4
Rosenthal, F.5
Gilboa, E.6
Golde, D.7
Oettgen, H.8
Steffans, T.9
Yang, S.Y.10
Wong, G.11
-
15
-
-
0006621226
-
Immunogenicity of a disabled infectious single cycle HSV-2 vaccine in phase 1 clinical trials in HSV-2 seropositive and seronegative volunteers
-
Abstract 22.008
-
HICKLING, J.K., CHISHOLM, S.E., DUNCAN, I.E., TAYLOR, E.J., BOSWELL, C., McLEAN, C.S., UTTRIDGE, J., ROBERTS, J.S.C., TOMASI, A., STANBERRY, L., BERNSTEIN, D.I., BOURSNELL, M.E.G., and INGLIS, S.C. (1998). Immunogenicity of a disabled infectious single cycle HSV-2 vaccine in phase 1 clinical trials in HSV-2 seropositive and seronegative volunteers. In 8th International Congress on Infectious Diseases. [Abstract 22.008]
-
(1998)
8th International Congress on Infectious Diseases
-
-
Hickling, J.K.1
Chisholm, S.E.2
Duncan, I.E.3
Taylor, E.J.4
Boswell, C.5
McLean, C.S.6
Uttridge, J.7
Roberts, J.S.C.8
Tomasi, A.9
Stanberry, L.10
Bernstein, D.I.11
Boursnell, M.E.G.12
Inglis, S.C.13
-
16
-
-
0028179056
-
Role of bone marrow derived cells in presenting MHC class I-restricted tumor antigens
-
HUANG, A.Y.C., GOLUMBEK, P., AHMADZADEH, M., JAFFEE, E., PARDOLL, D., and LEVITSKY, H. (1994). Role of bone marrow derived cells in presenting MHC class I-restricted tumor antigens. Science 264, 961-965.
-
(1994)
Science
, vol.264
, pp. 961-965
-
-
Huang, A.Y.C.1
Golumbek, P.2
Ahmadzadeh, M.3
Jaffee, E.4
Pardoll, D.5
Levitsky, H.6
-
17
-
-
0029003433
-
Expansion of mucin-reactive T-helper lymphocytes from patients with colorectal cancer
-
KIM, J.A., MARTIN, E., JR., MORGAN, C.J., ALDRICH, W., and TRIOZZI, P.L. (1995). Expansion of mucin-reactive T-helper lymphocytes from patients with colorectal cancer. Cancer Biother. 10, 115-123.
-
(1995)
Cancer Biother.
, vol.10
, pp. 115-123
-
-
Kim, J.A.1
Martin Jr., E.2
Morgan, C.J.3
Aldrich, W.4
Triozzi, P.L.5
-
18
-
-
0032191916
-
An innate sense of danger
-
MATZINGER, P. (1998). An innate sense of danger. Semin. Immunol. 10, 399-415.
-
(1998)
Semin. Immunol.
, vol.10
, pp. 399-415
-
-
Matzinger, P.1
-
19
-
-
0031836938
-
Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein
-
MELCHER, A., TODRYK, S., HARDWICK, N., FORD, M., JACOBSON, M., and VILE, R.G. (1998). Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein. Nature Med. 4, 581-587.
-
(1998)
Nature Med.
, vol.4
, pp. 581-587
-
-
Melcher, A.1
Todryk, S.2
Hardwick, N.3
Ford, M.4
Jacobson, M.5
Vile, R.G.6
-
20
-
-
0028908324
-
Paracrine cytokine adjuvants in cancer immunotherapy
-
PARDOLL, D.M. (1995). Paracrine cytokine adjuvants in cancer immunotherapy. Annu. Rev. Immunol. 13, 399-415.
-
(1995)
Annu. Rev. Immunol.
, vol.13
, pp. 399-415
-
-
Pardoll, D.M.1
-
21
-
-
0030944023
-
Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex-vivo granulocyte-macrophage colony-stimulating factor gene transfer
-
SIMONS, J.W., JAFFEE, E.M., WEBER, C.E., LEVITSKY, H.I., NELSON, W.O., CARDUCCI, M.A., LAZENBY, A.J., COHEN, L.K., FINN, C.C., CLIFT, S.M., HAUDA, K.M., BECK, L.A., LEIFERMAN, K.M., OWENS, A.H., PIANTADOSI, S., DRANOFF, G., MULLIGAN, R.C., PARDOLL, D.M., and MARSHAL, F. (1997). Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex-vivo granulocyte-macrophage colony-stimulating factor gene transfer. Cancer Res. 57, 1537-1546.
-
(1997)
Cancer Res.
, vol.57
, pp. 1537-1546
-
-
Simons, J.W.1
Jaffee, E.M.2
Weber, C.E.3
Levitsky, H.I.4
Nelson, W.O.5
Carducci, M.A.6
Lazenby, A.J.7
Cohen, L.K.8
Finn, C.C.9
Clift, S.M.10
Hauda, K.M.11
Beck, L.A.12
Leiferman, K.M.13
Owens, A.H.14
Piantadosi, S.15
Dranoff, G.16
Mulligan, R.C.17
Pardoll, D.M.18
Marshal, F.19
-
22
-
-
0032573225
-
Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma
-
SOIFFER, R., LYNCH, T., MIHM, M., JUNG, K., RHUDA, C., SCHMOLLINGER, J.C., HODI, F.S., LIEBSTER, L., LAN, P., MENTZER, S., SINGER, S., NEUBERG, D., PARRY, G., ROKOVICH, J., RICHARDS, L., DRAYER, J., BERNS, A., CLIFT, S., COHEN, L.K., MULLIGAN, R.C., and DRANOFF, G. (1998). Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc. Natl. Acad. Sci. U.S.A. 95, 13141-13146.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 13141-13146
-
-
Soiffer, R.1
Lynch, T.2
Mihm, M.3
Jung, K.4
Rhuda, C.5
Schmollinger, J.C.6
Hodi, F.S.7
Liebster, L.8
Lan, P.9
Mentzer, S.10
Singer, S.11
Neuberg, D.12
Parry, G.13
Rokovich, J.14
Richards, L.15
Drayer, J.16
Berns, A.17
Clift, S.18
Cohen, L.K.19
Mulligan, R.C.20
Dranoff, G.21
more..
-
23
-
-
2442759351
-
Safety, tolerability and viral containment of a disabled infectious single cycle HSV-2 vaccine evaluated in phase I clinical trials in HSV-2 seropositive and seronegative volunteers
-
Abstract 22.009
-
ST. CLAIR ROBERTS, J., UTTRIDGE, J.A., HICKLING, J.K., LOUDON, P.T., McLEAN, C.S., BOURSNELL, M.E.G., INGLIS, S.C., BELLI, J.A., BERNSTEIN, D.I., and STANBERRY, L. (1998). Safety, tolerability and viral containment of a disabled infectious single cycle HSV-2 vaccine evaluated in phase I clinical trials in HSV-2 seropositive and seronegative volunteers. In 8th International Congress of Infectious Diseases. [Abstract 22.009]
-
(1998)
8th International Congress of Infectious Diseases
-
-
St. Clair Roberts, J.1
Uttridge, J.A.2
Hickling, J.K.3
Loudon, P.T.4
McLean, C.S.5
Boursnell, M.E.G.6
Inglis, S.C.7
Belli, J.A.8
Bernstein, D.I.9
Stanberry, L.10
-
24
-
-
0021333292
-
Lymphoid infiltration and prognosis in colorectal carcinoma
-
SVENNEVIG, J.L., LUNDE, O.C., HOLTER, J., and BJORGSVIK, D. (1984). Lymphoid infiltration and prognosis in colorectal carcinoma. Br. J. Cancer 49, 375-377.
-
(1984)
Br. J. Cancer
, vol.49
, pp. 375-377
-
-
Svennevig, J.L.1
Lunde, O.C.2
Holter, J.3
Bjorgsvik, D.4
-
25
-
-
0031710994
-
Can immunotherapy by gene transfer tip the balance against colorectal cancer?
-
TODRYK, S.M., CHONG, H., PANDHA, H., LEMOINE, N.R., and VILE, R.G. (1998). Can immunotherapy by gene transfer tip the balance against colorectal cancer? Gut 43, 445-449.
-
(1998)
Gut
, vol.43
, pp. 445-449
-
-
Todryk, S.M.1
Chong, H.2
Pandha, H.3
Lemoine, N.R.4
Vile, R.G.5
-
26
-
-
0029042336
-
Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine
-
TSANG, K.Y., ZAREMBA, S., NIERODA, C.A., ZHU, M.Z., HAMILTON, J.M., and SCHLOM, J. (1995). Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine. J. Natl. Cancer Inst. 87, 982-990.
-
(1995)
J. Natl. Cancer Inst.
, vol.87
, pp. 982-990
-
-
Tsang, K.Y.1
Zaremba, S.2
Nieroda, C.A.3
Zhu, M.Z.4
Hamilton, J.M.5
Schlom, J.6
-
27
-
-
0033616482
-
Active specific immunotherapy for stage II and stage III human colon cancer: A randomised trial
-
VERMORKEN, J.B., CLAESSEN, A.M.E., VAN TINTEREN, H., GALL, H.E., EZINGA, R., MEIJER, S., SCHEPER, R.J., MEIJER, C.J.L.M., BLOEMENA, E., RANSOM, J.H., HANNA, M.G., JR., and PINEDO, H.M. (1999). Active specific immunotherapy for stage II and stage III human colon cancer: A randomised trial. Lancet 353, 345-350.
-
(1999)
Lancet
, vol.353
, pp. 345-350
-
-
Vermorken, J.B.1
Claessen, A.M.E.2
Van Tinteren, H.3
Gall, H.E.4
Ezinga, R.5
Meijer, S.6
Scheper, R.J.7
Meijer, C.J.L.M.8
Bloemena, E.9
Ransom, J.H.10
Hanna Jr., M.G.11
Pinedo, H.M.12
-
28
-
-
0029803117
-
Immunotherapy: Combinatorial molecular immunotherapy - A synthesis and suggestions
-
VILE, R.G., and CHONG, H. (1996). Immunotherapy: Combinatorial molecular immunotherapy - a synthesis and suggestions. Cancer Metastasis Rev. 15, 351-364.
-
(1996)
Cancer Metastasis Rev.
, vol.15
, pp. 351-364
-
-
Vile, R.G.1
Chong, H.2
-
29
-
-
0028385731
-
Gene transfer technologies for the gene therapy of cancer
-
VILE, R., and RUSSELL, S.J. (1994). Gene transfer technologies for the gene therapy of cancer. Gene Ther. 1, 88-98.
-
(1994)
Gene Ther.
, vol.1
, pp. 88-98
-
-
Vile, R.1
Russell, S.J.2
-
30
-
-
0028075655
-
Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component
-
VILE, R.G., NELSON, J.A., CASTLEDEN, S., CHONG, H., and HART, I.R. (1994). Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component. Cancer Res. 54, 6228-6234.
-
(1994)
Cancer Res.
, vol.54
, pp. 6228-6234
-
-
Vile, R.G.1
Nelson, J.A.2
Castleden, S.3
Chong, H.4
Hart, I.R.5
-
31
-
-
0030917683
-
Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk-killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression
-
VILE, R.G., CASTLEDEN, S.C., MARSHALL, J., CAMPLEJOHN, R., UPTON, C., and CHONG, H. (1997). Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk-killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression. Int. J. Cancer 71, 267-274.
-
(1997)
Int. J. Cancer
, vol.71
, pp. 267-274
-
-
Vile, R.G.1
Castleden, S.C.2
Marshall, J.3
Camplejohn, R.4
Upton, C.5
Chong, H.6
|