-
1
-
-
0037415611
-
Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process
-
Abrami, L., S. Liu, P. Cosson, S. H. Leppla, and F. G. van der Goot. 2003. Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process. J. Cell Biol. 160:321-328.
-
(2003)
J. Cell Biol.
, vol.160
, pp. 321-328
-
-
Abrami, L.1
Liu, S.2
Cosson, P.3
Leppla, S.H.4
Van Der Goot, F.G.5
-
2
-
-
0028818056
-
Synthesis of tight binding inhibitors and their action on the proprotein-processing enzyme furin
-
Angliker, H. 1995. Synthesis of tight binding inhibitors and their action on the proprotein-processing enzyme furin. J. Med. Chem. 38:4014-4018.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 4014-4018
-
-
Angliker, H.1
-
3
-
-
0027270903
-
The synthesis of inhibitors for processing protcinases and their action on the Kex2 proteinase of yeast
-
Angliker, H., P. Wikstrom, E. Shaw, C. Brenner, and R. S. Fuller. 1993. The synthesis of inhibitors for processing protcinases and their action on the Kex2 proteinase of yeast. Biochem. J. 293:75-81.
-
(1993)
Biochem. J.
, vol.293
, pp. 75-81
-
-
Angliker, H.1
Wikstrom, P.2
Shaw, E.3
Brenner, C.4
Fuller, R.S.5
-
4
-
-
6944243965
-
Chloroquine enhances survival in Bacillus anthracis intoxication
-
Artenstein, A. W., S. M. Opal, P. Cristofaro, J. E. Palardy, N. A. Parejo, M. D. Green, and J. W. Jhung. 2004. Chloroquine enhances survival in Bacillus anthracis intoxication. J. Infect. Dis. 190:1655-1660.
-
(2004)
J. Infect. Dis.
, vol.190
, pp. 1655-1660
-
-
Artenstein, A.W.1
Opal, S.M.2
Cristofaro, P.3
Palardy, J.E.4
Parejo, N.A.5
Green, M.D.6
Jhung, J.W.7
-
5
-
-
0033868243
-
Proteolytic activation of receptor-bound anthrax protective antigen on macrophages promotes its internalization
-
Beauregard, K. E., R. J. Collier, and J. A. Swanson. 2000. Proteolytic activation of receptor-bound anthrax protective antigen on macrophages promotes its internalization. Cell. Microbiol. 2:251-258.
-
(2000)
Cell. Microbiol.
, vol.2
, pp. 251-258
-
-
Beauregard, K.E.1
Collier, R.J.2
Swanson, J.A.3
-
6
-
-
0035829509
-
Identification of the cellular receptor for anthrax toxin
-
Bradley, K. A., J. Mogridge, M. Mourez, R. J. Collier, and J. A. Young. 2001. Identification of the cellular receptor for anthrax toxin. Nature 414:225-229.
-
(2001)
Nature
, vol.414
, pp. 225-229
-
-
Bradley, K.A.1
Mogridge, J.2
Mourez, M.3
Collier, R.J.4
Young, J.A.5
-
7
-
-
0027973010
-
Accurate and efficient cleavage of the human insulin proreceptor by the human proprotein-processing protease furin. Characterization and kinetic parameters using the purified, secreted soluble protease expressed by a recombinant baculovirus
-
Bravo, D. A., J. B. Gleason, R. I. Sanchez, R. A. Roth, and R. S. Fuller. 1994. Accurate and efficient cleavage of the human insulin proreceptor by the human proprotein-processing protease furin. Characterization and kinetic parameters using the purified, secreted soluble protease expressed by a recombinant baculovirus. J. Biol. Chem. 269:25830-25837.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 25830-25837
-
-
Bravo, D.A.1
Gleason, J.B.2
Sanchez, R.I.3
Roth, R.A.4
Fuller, R.S.5
-
8
-
-
0036468526
-
Quickening the pace of anthrax research: Three advances point towards possible therapies
-
Chaudry, G. J., M. Moayeri, S. Liu, and S. H. Leppla. 2002. Quickening the pace of anthrax research: three advances point towards possible therapies. Trends Microbiol. 10:58-62.
-
(2002)
Trends Microbiol.
, vol.10
, pp. 58-62
-
-
Chaudry, G.J.1
Moayeri, M.2
Liu, S.3
Leppla, S.H.4
-
9
-
-
0033539028
-
Anthrax
-
Dixon, T. C., M. Meselson, J. Guillemin, and P. C. Hanna. 1999. Anthrax. N. Engl. J. Med. 341:815-826.
-
(1999)
N. Engl. J. Med.
, vol.341
, pp. 815-826
-
-
Dixon, T.C.1
Meselson, M.2
Guillemin, J.3
Hanna, P.C.4
-
10
-
-
0033779930
-
Chloroquine and desethylchloroquine eoncentrations in blood cells and plasma from Indian patients infected with sensitive or resistant Plasmodium falciparum
-
Dua, V. K., N. C. Gupta, P. K. Kar, J. Nand, G. Edwards, V. P. Sharma, and S. K. Subbarao. 2000. Chloroquine and desethylchloroquine eoncentrations in blood cells and plasma from Indian patients infected with sensitive or resistant Plasmodium falciparum. Ann. Trop. Med. Parasitol. 94:565-570.
-
(2000)
Ann. Trop. Med. Parasitol.
, vol.94
, pp. 565-570
-
-
Dua, V.K.1
Gupta, N.C.2
Kar, P.K.3
Nand, J.4
Edwards, G.5
Sharma, V.P.6
Subbarao, S.K.7
-
11
-
-
18244414803
-
Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
-
Duesbery, N. S., C. P. Webb, S. H. Leppla, V. M. Gordon, K. R. Klimpel, T. D. Copeland, N. G. Ahn, M. K. Oskarsson, K. Fukasawa, K. D. Paull, and G. F. Vande Woude. 1998. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science 280:734-737.
-
(1998)
Science
, vol.280
, pp. 734-737
-
-
Duesbery, N.S.1
Webb, C.P.2
Leppla, S.H.3
Gordon, V.M.4
Klimpel, K.R.5
Copeland, T.D.6
Ahn, N.G.7
Oskarsson, M.K.8
Fukasawa, K.9
Paull, K.D.10
Vande Woude, G.F.11
-
12
-
-
0023199137
-
Temperature dependence of the acid dissociation constants of chloroquine
-
Ferrari, V., and D. J. Cutler. 1987. Temperature dependence of the acid dissociation constants of chloroquine. J. Pharm. Sci. 76:554-556.
-
(1987)
J. Pharm. Sci.
, vol.76
, pp. 554-556
-
-
Ferrari, V.1
Cutler, D.J.2
-
13
-
-
0003481596
-
-
W. H. Freeman and Co., New York, N.Y.
-
Fersht, A. R. 1985. Enzyme structure and mechanism, p. 106-107. W. H. Freeman and Co., New York, N.Y.
-
(1985)
Enzyme Structure and Mechanism
, pp. 106-107
-
-
Fersht, A.R.1
-
14
-
-
0022891493
-
Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process
-
Friedlander, A. M. 1986. Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process. J. Biol. Chem. 261:7123-7126.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 7123-7126
-
-
Friedlander, A.M.1
-
15
-
-
0027470890
-
Characterization of macrophage sensitivity and resistance to anthrax lethal toxin
-
Friedlander, A. M., R. Bhatnagar, S. H. Leppla, L. Johnson, and Y. Singh. 1993. Characterization of macrophage sensitivity and resistance to anthrax lethal toxin. Infect. Immun. 61:245-252.
-
(1993)
Infect. Immun.
, vol.61
, pp. 245-252
-
-
Friedlander, A.M.1
Bhatnagar, R.2
Leppla, S.H.3
Johnson, L.4
Singh, Y.5
-
16
-
-
0028872463
-
Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases
-
Gordon, V. M., K. R. Klimpel, N. Arora, M. A. Henderson, and S. H. Leppla. 1995. Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases. Infect. Immun. 63:82-87.
-
(1995)
Infect. Immun.
, vol.63
, pp. 82-87
-
-
Gordon, V.M.1
Klimpel, K.R.2
Arora, N.3
Henderson, M.A.4
Leppla, S.H.5
-
17
-
-
0023932170
-
Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin
-
Gordon, V. M., S. H. Leppla, and E. L. Hewlett. 1988. Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin. Infect. Immun. 56:1066-1069.
-
(1988)
Infect. Immun.
, vol.56
, pp. 1066-1069
-
-
Gordon, V.M.1
Leppla, S.H.2
Hewlett, E.L.3
-
18
-
-
0024817865
-
Molecular dynamics refinement of a thermitase-eglin-c complex at 1.98 a resolution and comparison of two crystal forms that differ in calcium content
-
Gros, P., C. Betzel, Z. Dauter, K. S. Wilson, and W. G. Hol. 1989. Molecular dynamics refinement of a thermitase-eglin-c complex at 1.98 A resolution and comparison of two crystal forms that differ in calcium content. J. Mol. Biol. 210:347-367.
-
(1989)
J. Mol. Biol.
, vol.210
, pp. 347-367
-
-
Gros, P.1
Betzel, C.2
Dauter, Z.3
Wilson, K.S.4
Hol, W.G.5
-
19
-
-
1542297713
-
Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases
-
Holyoak, T., C. A. Kettner, G. A. Petsko, R. S. Fuller, and D. Ringe. 2004. Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases. Biochemistry 43:2412-2421.
-
(2004)
Biochemistry
, vol.43
, pp. 2412-2421
-
-
Holyoak, T.1
Kettner, C.A.2
Petsko, G.A.3
Fuller, R.S.4
Ringe, D.5
-
20
-
-
0037647026
-
2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor
-
Holyoak, T., M. A. Wilson, T. D. Fenn, C. A. Kettner, G. A. Petsko, R. S. Fuller, and D. Ringe. 2003. 2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor. Biochemistry 42:6709-6718.
-
(2003)
Biochemistry
, vol.42
, pp. 6709-6718
-
-
Holyoak, T.1
Wilson, M.A.2
Fenn, T.D.3
Kettner, C.A.4
Petsko, G.A.5
Fuller, R.S.6
Ringe, D.7
-
21
-
-
0035929401
-
Synthesis of boronic acid analogues of alpha-amino acids by introducing side chains as electrophiles
-
Jagannathan, S., T. P. Forsyth, and C. A. Kettner. 2001. Synthesis of boronic acid analogues of alpha-amino acids by introducing side chains as electrophiles. J. Org. Chem. 66:6375-6380.
-
(2001)
J. Org. Chem.
, vol.66
, pp. 6375-6380
-
-
Jagannathan, S.1
Forsyth, T.P.2
Kettner, C.A.3
-
22
-
-
0032560449
-
α1-antitrypsin Portland, a bioengineered serpin highly selective for furin: Application as an antipathogenic agent
-
Jean, F., K. Stella, L. Thomas, G. Liu, Y. Xiang, A. J. Reason, and G. Thomas. 1998. α1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent. Proc. Natl. Acad. Sci. USA 95:7293-7298.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7293-7298
-
-
Jean, F.1
Stella, K.2
Thomas, L.3
Liu, G.4
Xiang, Y.5
Reason, A.J.6
Thomas, G.7
-
23
-
-
0021723091
-
Inhibition of the serine proteases leukocyte elastase, pancreatic elastase, cathepsin G, and chymotrypsin by peptide boronic acids
-
Kettner, C. A., and A. B. Shenvi. 1984. Inhibition of the serine proteases leukocyte elastase, pancreatic elastase, cathepsin G, and chymotrypsin by peptide boronic acids. J. Biol. Chem. 259:15106-15114.
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 15106-15114
-
-
Kettner, C.A.1
Shenvi, A.B.2
-
24
-
-
0026498189
-
Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin
-
Klimpel, K. R., S. S. Molloy, G. Thomas, and S. H. Leppla. 1992. Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin. Proc. Natl. Acad. Sci. USA 89:10277-10281.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 10277-10281
-
-
Klimpel, K.R.1
Molloy, S.S.2
Thomas, G.3
Leppla, S.H.4
-
25
-
-
0002978054
-
The characterization of enzyme inhibition
-
A. J. Barrett and G. Salvesen (ed.). Elsevier, Amsterdam, The Netherlands
-
Knight, C. G. 1986. The characterization of enzyme inhibition, p. 23-51. In A. J. Barrett and G. Salvesen (ed.), Proteinase inhibitors. Elsevier, Amsterdam, The Netherlands.
-
(1986)
Proteinase Inhibitors
, pp. 23-51
-
-
Knight, C.G.1
-
26
-
-
0034642235
-
Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin
-
Komiyama, T., and R. S. Fuller. 2000. Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin. Biochemistry 39:15156-15165.
-
(2000)
Biochemistry
, vol.39
, pp. 15156-15165
-
-
Komiyama, T.1
Fuller, R.S.2
-
27
-
-
0037478705
-
Optimization of protease-inhibitor interactions by randomizing adventitious contacts
-
Komiyama, T., B. VanderLugt, M. Fugere, R. Day, R. J. Kaufman, and R. S. Fuller. 2003. Optimization of protease-inhibitor interactions by randomizing adventitious contacts. Proc. Natl. Acad. Sci. USA 100:8205-8210.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8205-8210
-
-
Komiyama, T.1
Vanderlugt, B.2
Fugere, M.3
Day, R.4
Kaufman, R.J.5
Fuller, R.S.6
-
28
-
-
0033551805
-
Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methyleoumarinamides
-
Krysan, D. J., N. C. Rockwell, and R. S. Fuller. 1999. Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methyleoumarinamides. J. Biol. Chem. 274:23229-23234.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 23229-23234
-
-
Krysan, D.J.1
Rockwell, N.C.2
Fuller, R.S.3
-
29
-
-
0013159236
-
Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization
-
Liu, S., and S. H. Leppla. 2003. Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization. J. Biol. Chem. 278:5227-5234.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 5227-5234
-
-
Liu, S.1
Leppla, S.H.2
-
30
-
-
0028222309
-
Significant reduction in chloroquine bioavailability following coadministration with the Sudanese beverages Aradaib, Karkadi and Lemon
-
Mahmoud, B. M., H. M. Ali, M. M. Homeida, and J. L. Bennett. 1994. Significant reduction in chloroquine bioavailability following coadministration with the Sudanese beverages Aradaib, Karkadi and Lemon. J. Antimicrob. Chemother. 33:1005-1009.
-
(1994)
J. Antimicrob. Chemother.
, vol.33
, pp. 1005-1009
-
-
Mahmoud, B.M.1
Ali, H.M.2
Homeida, M.M.3
Bennett, J.L.4
-
31
-
-
0028018856
-
Anthrax protective antigen forms oligomers during intoxication of mammalian cells
-
Milne, J. C., D. Furlong, P. C. Hanna, J. S. Wall, and R. J. Collier. 1994. Anthrax protective antigen forms oligomers during intoxication of mammalian cells. J. Biol. Chem. 269:20607-20612.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 20607-20612
-
-
Milne, J.C.1
Furlong, D.2
Hanna, P.C.3
Wall, J.S.4
Collier, R.J.5
-
33
-
-
10744223044
-
Identification of small molecule inhibitors of anthrax lethal factor
-
Panchal, R. G., A. R. Hermone, T. L. Nguyen, T. Y. Wong, R. Schwarzenbacher, J. Schmidt, D. Lane, C. McGrath, B. E. Turk, J. Burnett, M. J. Aman, S. Little, E. A. Sausville, D. W, Zaharevitz, L. C. Cantley, R. C. Liddington, R. Gussio, and S. Bavari. 2004. Identification of small molecule inhibitors of anthrax lethal factor. Nat. Struct. Mol. Biol. 11:67-72.
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 67-72
-
-
Panchal, R.G.1
Hermone, A.R.2
Nguyen, T.L.3
Wong, T.Y.4
Schwarzenbacher, R.5
Schmidt, J.6
Lane, D.7
McGrath, C.8
Turk, B.E.9
Burnett, J.10
Aman, M.J.11
Little, S.12
Sausville, E.A.13
Zaharevitz, D.W.14
Cantley, L.C.15
Liddington, R.C.16
Gussio, R.17
Bavari, S.18
-
34
-
-
4344695207
-
Cross-inhibition between furin and lethal factor inhibitors
-
Peinado, J. R., M. M. Kacprzak, S. H. Leppla, and I. Lindberg. 2004. Cross-inhibition between furin and lethal factor inhibitors. Biochem. Biophys. Res. Commun. 321:601-605.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.321
, pp. 601-605
-
-
Peinado, J.R.1
Kacprzak, M.M.2
Leppla, S.H.3
Lindberg, I.4
-
35
-
-
0031052342
-
Crystal structure of the anthrax toxin protective antigen
-
Petosa, C., R. J. Collier, K. R. Kumpel, S. H. Leppla, and R. C. Liddington. 1997. Crystal structure of the anthrax toxin protective antigen. Nature 385:833-838.
-
(1997)
Nature
, vol.385
, pp. 833-838
-
-
Petosa, C.1
Collier, R.J.2
Kumpel, K.R.3
Leppla, S.H.4
Liddington, R.C.5
-
36
-
-
4344670926
-
Furin inhibition by compounds of copper and zinc
-
Podsiadlo, P., T. Komiyama, R. S. Fuller, and O. Blum. 2004. Furin inhibition by compounds of copper and zinc. J. Biol. Chem. 279:36219-36227.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 36219-36227
-
-
Podsiadlo, P.1
Komiyama, T.2
Fuller, R.S.3
Blum, O.4
-
37
-
-
0036882391
-
Precursor processing by kex2/furin proteases
-
Rockwell, N. C., D. J. Krysan, T. Komiyama, and R. S. Fuller. 2002. Precursor processing by kex2/furin proteases. Chem. Rev. 102:4525-4548.
-
(2002)
Chem. Rev.
, vol.102
, pp. 4525-4548
-
-
Rockwell, N.C.1
Krysan, D.J.2
Komiyama, T.3
Fuller, R.S.4
-
38
-
-
0346881395
-
Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo
-
Sarac, M. S., J. R. Peinado, S. H. Leppla, and I. Lindberg. 2004. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect. Immun. 72:602-605.
-
(2004)
Infect. Immun.
, vol.72
, pp. 602-605
-
-
Sarac, M.S.1
Peinado, J.R.2
Leppla, S.H.3
Lindberg, I.4
-
39
-
-
0024837128
-
A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo
-
Singh, Y., V. K. Chaudhary, and S. H. Leppla. 1989. A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo. J. Biol. Chem. 264:19103-19107.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 19103-19107
-
-
Singh, Y.1
Chaudhary, V.K.2
Leppla, S.H.3
-
40
-
-
0442307497
-
Antimalarial drug toxicity: A review
-
Taylor, W. R., and N. J. White. 2004. Antimalarial drug toxicity: a review. Drug Saf. 27:25-61.
-
(2004)
Drug Saf.
, vol.27
, pp. 25-61
-
-
Taylor, W.R.1
White, N.J.2
-
41
-
-
0024369652
-
Recent developments in the understanding of the pharmacokinetics and mechanism of action of chloroquine
-
Titus, E. O. 1989. Recent developments in the understanding of the pharmacokinetics and mechanism of action of chloroquine. Ther. Drug Monit. 11:369-379.
-
(1989)
Ther. Drug Monit.
, vol.11
, pp. 369-379
-
-
Titus, E.O.1
-
42
-
-
0347192782
-
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor
-
Turk, B. E., T. Y. Wong, R. Schwarzenbacher, E. T. Jarrell, S. H. Leppla, R. J. Collier, R. C. Liddington, and L. C. Cantley. 2004. The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat. Struct. Mol. Biol. 11:60-66.
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 60-66
-
-
Turk, B.E.1
Wong, T.Y.2
Schwarzenbacher, R.3
Jarrell, E.T.4
Leppla, S.H.5
Collier, R.J.6
Liddington, R.C.7
Cantley, L.C.8
|