Quantitative characterization of furin specificity: Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides

Journal of Biological Chemistry

Volumn 274, Issue 33, 1999, Pages 23229-23234

  Krysan, Damian J ^a   Rockwell, Nathan C ^a,b   Fuller, Robert S ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COUMARIN DERIVATIVE; FURIN;

ARTICLE; CATALYSIS; ENERGY TRANSFER; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; PRIORITY JOURNAL; QUANTITATIVE ASSAY;

AMIDES; AMINO ACID SEQUENCE; COUMARINS; ENERGY METABOLISM; FURIN; HYDROLYSIS; KINETICS; MOLECULAR SEQUENCE DATA; PROPROTEIN CONVERTASES; SACCHAROMYCES CEREVISIAE PROTEINS; SERINE PROTEINASE INHIBITORS; SUBSTRATE SPECIFICITY; SUBTILISINS;

EUKARYOTA; FELIS CATUS; MAMMALIA;

EID: 0033551805     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.33.23229     Document Type: Article

References (35)

1. Steiner, D. F. (1998) Curr. Opin. Chem. Biol. 2, 31-39
2. Fuller, R. S., Brake, A. J., and Thorner, J. (1989) Science 246, 482-486
3. Nakayama, K. (1997) Biochem. J. 327, 625-635
4. Molloy, S. S., Thomas, L., VanSlyke, J. K., Stenberg, P. E., and Thomas, G. (1994) EMBO J. 13, 18-33
5. Cui, Y., Jean, F., Thomas, G., and Christian, J. L. EMBO J. (1998) 17, 4735-4743
6. Robertson, B. J., Moehring, J. M., and Moehring, T. J. (1993) J. Biol. Chem. 268, 24274-24277
7. Bravo, D. A., Gleason, J. B., Sanchez, R. I., Roth, R. A., and Fuller, R. S. (1994) J. Biol. Chem. 269, 25830-25837
8. Rehemtulla, A., and Kaufman, R. J. (1992) Curr. Opin. Biol Technol 3, 560-565
9. Pei, D., and Weiss, S. J. (1995) Nature 375, 244-247
10. Volchkov, V. E., Feldmann, H., Volchkova, V. A., and Klenk, H. D. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 5762-5767
11. Garten, W., Hallenberger, S., Ortmann, D., Schafer, W., Vey, M., Angliker, H., Shaw, E., and Klenk, H. D. (1994) Biochimie (Paris) 76, 217-225
12. Klimpel, K. R., Molloy, S. S., Thomas, G., and Leppla, S. H. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 10277-10281
13. Molloy, S. S., Bresnahan, P. A., Leppla, S. H., Klimpel, K. R., and Thomas, G. (1992) J. Biol. Chem. 267, 16396-16402
14. Jean, F., Boudreault, A., Basak, A., Seidah, N. G., and Lazure, C. (1995) J. Biol. Chem 270, 19225-19231
15. Schechter, I., and Berger, A. (1967) Biochem. Biophys. Res. Commun. 27, 157-162
16. Roebroek, A. J. M., Umans, L., Pauli, I. G. L., Robertson, E. L., van Leuven, F., Van de Ven, W. J. M., and Constam, D. B. (1998) Development 25, 4863-4676
17. Angliker, H., Neumann, U., Molloy, S. S., and Thomas, G. (1995) Anal. Biochem. 224, 409-412
18. Jean, F., Basak, A., DiMaio, J., Seidah, N. G., Seidah, N. G., and Lazure, C. (1995) Biochem. J. 307, 689-695
19. Lazure, C., Gauthier, D., Jean, F., Boudreault, A., Seidah, N. G., Bennett, H. P. J., and Hendy, G. N. (1998) J. Biol. Chem. 273, 8572-8580
20. Brenner, C., and Fuller, R. S. (1992) Proc. Natl. Acad. Sci. U. S. A 86, 922-926
21. Deleted in proof
22. Rockwell, N. C., Wang, G. T., Krafft, G. A., and Fuller, R. S. (1997) Biochemistry 36, 1912-1917
23. Zimmerman, M., Ashe, B., Yurewicz, E. C., and Patel, G. (1977) Anal. Biochem. 78, 47-51
24. Fersht, A. R. (1985) in Enzyme Structure and Mechanism, pp. 80-88, W. H. Freeman and Co., New York
25. Rockwell, N. C., and Fuller, R. S. (1998) Biochemistry 37, 3386-3391
26. Philipp, M., and Bender, M. L. (1983) Mol. Cell Biochem. 51, 5-32
27. Takeuchi, Y., Satow, Y., Nakamura, K. T., and Mitusi, Y. (1991) J. Mol. Biol. 221, 309-325
28. Siezen, R. J., Creemers, J. W. R., and Van de Ven, W. M. J. (1994) Eur. J. Biochem. 222, 255-266
29. Grøn, H., Meldal, M., and Breddam, K. (1992) Biochemistry 31, 6011-6018
30. Ngola, S. M., Kearney, P. C., Mecozzi, S., Russell, K., and Dougherty, D. A. (1999) J. Am. Chem. Soc. 121, 1192-1201
31. Anderson, E. D., VanSlyke, J. K., Thulin, C. D., Jean, F., and Thomas, G. (1997) EMBO J. 16, 1508-1518
32. Duguay, S. J., Milewski, W. M., Young, B. D., Nakayama, K., and Steiner, D. F. (1997) J. Biol. Chem. 272, 6663-6670
33. Stieneke-Grober, A., Vey, M., Angliker, H., Shaw, E., Thomas, G., Roberts, C., Klenk, H.-D., and Garten, W. (1992) EMBO J. 11, 2407-2414
34. Walker, J. A., Molloy, S. S., Thomas, G., Sakaguchi, T., Yoshida, T., Chambers, T. M., and Kawaoka, Y. (1994) J. Virol. 68, 1213-1218
35. Gotoh, B., Ohnishi, Y., Inocencio, N. M., Esaki, E., Nakayama, K., Barr, J., Thomas, G., and Nagai, Y. (1992) J. Virol. 66, 6391-6397