Furin inhibition by compounds of copper and zinc

Journal of Biological Chemistry

Volumn 279, Issue 35, 2004, Pages 36219-36227

  Podsiadlo, Paul ^a   Komiyama, Tomoko ^b   Fuller, Robert S ^b   Blum, Ofer ^a,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CHELATION; COPPER; PROTEINS; YEAST; ZINC;

ANDROGRAPHOLIDES; CHELATES;

ENZYME INHIBITION;

4 (4 TOLYL) 2,2':6',2'' TERPYRIDINE; COPPER; FURIN; NATURAL PRODUCT; PEPTIDE DERIVATIVE; PROTEIN; PROTEIN KEX2; PYRIDINE DERIVATIVE; SUBTILISIN; SUBTILISIN RELATED PROPROTEIN CONVERTASE; UNCLASSIFIED DRUG; ZINC;

ARTICLE; CHELATION; CONTROLLED STUDY; DRUG POTENCY; DRUG TARGETING; INHIBITION KINETICS; MATHEMATICAL ANALYSIS; METAL BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; REGULATORY MECHANISM; SOLVATION;

BINDING SITES; CATALYSIS; CHLORIDES; COPPER; DNA MUTATIONAL ANALYSIS; FURIN; HISTIDINE; HUMANS; INHIBITORY CONCENTRATION 50; IONS; KINETICS; MERCURY; MODELS, CHEMICAL; PROPROTEIN CONVERTASES; PYRIDINES; SACCHAROMYCES CEREVISIAE PROTEINS; TIME FACTORS; ZINC; ZINC COMPOUNDS;

EID: 4344670926     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400338200     Document Type: Article

References (36)

1. Zhou, A., Webb, G., Zhu, X., and Steiner, D. F. (1999) J. Biol. Chem. 274, 20745-20748
2. Steiner, D. F. (2001) in The Enzyme XXII (Dalbey, R. E., and Sigman, D. S., eds) pp. 163-198, Academic Press, San Diego
3. Rockwell, N. C., Krysan, D. J., Komiyama, T., and Fuller, R. S. (2002) Chem. Rev. 102, 4525-4548
4. Thomas, G. (2002) Nat. Rev. Mol. Cell Biol. 3, 753-766
5. Molloy, S. S., Anderson, E. D., Jean, F., and Thomas, G. (1999) Trends Cell Biol. 9, 28-35
6. Fugère, M., and Day, R. Curr. Pharma. Des. 8, 125-133
7. Jean, F., Thomas, L., Molloy, S. S., Liu, G., Jarvis, M. A., Nelson, J. A., and Thomas, G. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 2864-2869
8. Komiyama, T., VanderLugt, B., Fugère, M., Day, R., Kaufman, R. J., and Fuller, R. S. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 8205-8210
9. Basak, A., Cooper, S., Roberge, A. G., Banik, U. K, Chretien, M., and Seidah, N. G. (1999) Biochem. J. 338, 107-113
10. Komiyama, T., and Fuller, R. S. (2000) Biochemistry 39, 15156-15165
11. Bravo, D. A., Gleason, J. B., Sanchez, R. I., Roth, R. A., and Fuller, R. S. (1994) J. Biol. Chem. 269, 25830-25837
12. Krysan, D. J., Rockwell, N. C., and Fuller, R. S. (1999) J. Biol. Chem. 274, 23229-23234
13. Rockwell, N. C., Wang, G. T., Krafft, G. A., and Fuller, R. S. (1997) Biochemistry 36, 1912-1917
14. Hill, M. G., Bailey, J. A., Miskowski, V. M., and Gray, H. B. (1996) Inorg. Chem. 35, 4585-4590
15. Constable, E. C., Lewis, J., Liptrot, M. C., and Raithby, P. R. (1990) Inorg. Chim. Acta 178, 47-54
16. Harris, C. M., and Lockyer, T. N. (1970) Aust. J. Chem. 23, 673-682
17. Bieth, J. G. (1995) Methods Enzymol. 248, 59-84
18. Brenner, C., and Fuller, R. S. (1992) Proc. Natl. Acad. Sci., U. S. A. 89, 922-926
19. Brinkerhoff, C. J., Podsiadlo, P., Komiyama, T., Fuller, R. S., and Blum, O. (2002) Chem. Bio. Chem. 3, 1141-1143
20. Kunjappu, J. T. (1991) J. Photochem. Photobiol. A 56, 365-368
21. Holyoak, T., Wilson, M. A., Fenn, T. D., Kettner, C. A., Petsko, G. A., Fuller, R. S., and Ringe, D. (2003) Biochemistry, 42, 6709-6718
22. Müller, A., and Saenger, W. (1993) J. Biol. Chem. 268, 26150-26154
23. Henrich, S., Cameron, A., Bourenkov, G. P., Kiefersauer, R., Hubert, R., Lindberg, I., Bode, W., and Than, M. E., (2003) Nat. Struct. Biol. 10, 520-526
24. Hathaway, B. J. (1987) in Comprehensive Coordination Chemistry, Vol. 5, (Wilkinson G., ed) pp. 533-774, Pergamon
25. Keim, W., and Schwederski, B. (1994) Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life, pp. 20, 242-266, Wiley, Chichester, UK
26. Cornilsen, B. C., and Nakamoto, K. (1974) J. Inorg. Nucl. Chem. 38, 2467-2471
27. Schmidt, K. H., and Müller, A. (1975) Inorg. Chem. 14, 2183-2187
28. Saxena, A. K, Singh, T. P., Peters, K., Fittkau, S., Visanji, M., Wilson, K. S., and Betzel, C. (1996) Proteins 25, 195-201
29. Keim, W., and Schwederski, B. (1994) Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life, pp. 6-38, Wiley, Chichester, UK
30. O'Halloran, T. V., and Culotta, V. C. (2000) J. Biol. Chem. 275, 25057-25060
31. Ambundo, E. A., Deydier, M. -V., Grail, A. J., Aguera-Vega, N., Dressel, L. T., Cooper, T. H., Heeg, M. J., Ochrymowycz, L. A., and Rorabacher, D. B. (1999) Inorg. Chem. 38, 4233-4242
32. Ohta, T., Tachiyama, T., Yoshizawa, K., Yamabe, T., Uchida, T., and Kitagawa, T. (2000) Inorg. Chem. 39, 4358-4369
33. Lippard, S. J., and Berg, J. M. (1994) Principles of Bioinorganic Chemistry, pp. 21-41, University Science, Mill Valley, CA
34. Rae, T. D., Schmidt, P. J., Pufahl, R. A., Culotta, V. C., and O'Halloran, T. V. (1999) Science 284, 805-808
35. Hitomi, Y., Outten, C. E., and O'Halloran, T. V. (2001) J. Am. Chem. Soc. 123, 8614-8615
36. Cameron, A., Appel, J., Houghten, R. A., and Lindberg, I. (2000) J. Biol. Chem. 275, 36741-36749