Protection against Anthrax Toxemia by Hexa-D-Arginine In Vitro and In Vivo

Infection and Immunity

Volumn 72, Issue 1, 2004, Pages 602-605

  Sarac, Miroslav S ^a   Peinado, Juan R ^a   Leppla, Stephen H ^b   Lindberg, Iris ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX TOXIN; ANTIGEN; DEXTRO ARGININE; FURIN; HEXA DEXTRO ARGININE; POLYPEPTIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTHRAX; ARTICLE; BACILLUS ANTHRACIS; CELL COMPARTMENTALIZATION; CELL DEATH; ENDOSOME; ENZYME ACTIVATION; LUNG ALVEOLUS MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN DEGRADATION; SURVIVAL RATE; TOXEMIA;

ANIMALS; ANTHRAX; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; CELL LINE; ENZYME INHIBITORS; FURIN; MACROPHAGES, ALVEOLAR; MALE; PEPTIDES; RATS; RATS, INBRED F344; TOXEMIA;

EID: 0346881395     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.1.602-605.2004     Document Type: Article

References (26)

1. Ascenzi, P., P. Visca, G. Ippolito, A. Spallarossa, M. Bolognesi, and C. Montecucco. 2002. Anthrax toxin: a tripartite lethal combination. FEBS Lett. 531:384-388.
2. Brossier, F., and M. Mock. 2001. Toxins of Bacillus anthracis. Toxicon 39:1747-1755.
3. Brossier, F., M. Weber-Levy, M. Mock, and J. C. Sirard. 2000. Role of toxin functional domains in anthrax pathogenesis. Infect. Immun. 68:1781-1786.
4. Cameron, A., J. Appel, R. A. Houghten, and I. Lindberg. 2000. Polyarginines are potent furin inhibitors. J. Biol. Chem. 275:36741-36749.
5. Chaudry, G. J., M. Moayeri, S. Liu, and S. H. Leppla. 2001. Quickening the pace of anthrax research: three advances point to possible therapies. Trends Microbiol. 10:58-62.
6. Ezzell, J. W., B. E. lvins, and S. H. Leppla. 1984. Immunoelectrophoretic analysis, toxicity, and kinetics of in vitro production of the protective antigen and lethal factor components of Bacillus anthracis toxin. Infect. Immun. 45:761-767.
7. Flick-Smith, H. C., N. J. Walker, P. Gibson, H. Bullifent, S. Hayward, J. Miller, R. W. Titball, and E. D. Williamson. 2002. A recombinant carboxy-terminal domain of the protective antigen of Bacillus anthracis protects mice against anthrax infection. Infect. Immun. 70:1653-1656.
8. Friedman, T. C., V. M. Gordon, S. H. Leppla, K. R. Klimpel, N. P. Birch, and Y. P. Loh. 1995. In vitro processing of anthrax toxin protective antigen by recombinant PC1 (SPC3) and bovine intermediate lobe secretory vesicle membranes. Arch. Biochem. Biophys. 316:5-13.
9. Gordon, V. M., A. Rehemtulla, and S. H. Leppla. 1997. A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen. Infect. Immun. 65:3370-3375.
10. Henrich, S., A. Cameron, G. P. Bourenkov, R. Kiefersauer, R. Huber, I. Lindberg, W. Bode, and M. E. Than. 2003. The crystal structure of the proprotein processing proteinase furin explains its stringent specificity. Nat. Struct. Biol. 10:520-526.
11. Klimpel, K., S. Molloy, G. Thomas, and S. Leppla. 1992. Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin. Proc. Natl. Acad. Sci. USA 89:10277-10281.
12. Lacy, D. B., and R. J. Collier. 2002. Structure and function of anthrax toxin. Curr. Top. Microbiol. Immunol. 271:61-85.
13. Leppla, S. H. 1999. p. 243-263. In J. A. Alouf and J. Freer (ed.), Comprehensive sourcebook of bacterial protein toxins. Academic Press, London, United Kingdom.
14. Leppla, S. H. 2001. A dominant-negative therapy for anthrax. Nat. Med. 7:659-660.
15. Leppla, S. H., N. Arora, and M. Varughese. 1999. Anthrax toxin fusion proteins for intracellular delivery of macromolecules. J. Appl. Microbiol. 87:284.
16. Leppla, S. H., J. B. Robbins, R. Schneerson, and J. Shiloach. 2002. Development of an improved vaccine for anthrax. J. Clin. Investig. 110:141-144.
17. Maynard, J. A., C. B. M. Maassen, S. H. Leppla, K. Brasky, J. L. Patterson, B. L. Iverson, and G. Georgiou. 2002. Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity. Nat. Biotechnol. 20:597-601.
18. Molloy, S. S., P. A. Bresnahan, S. H. Leppla, K. R. Klimpel, and G. Thomas. 1992. Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. J. Biol. Chem. 267:16396-16402.
19. Mourez, M., R. S. Kane, J. Mogridge, S. Metallo, P. Deschatelets, B. R. Sellman, G. M. Whitesides, and R. J. Collier. 2001. Designing a polyvalent inhibitor of anthrax toxin. Nat. Biotechnol. 19:958-961.
20. Petosa, C., R. J. Collier, K. R. Klimpel, S. H. Leppla, and R. C. Liddington. 1997. Crystal structure of the anthrax toxin protective antigen. Nature 385:833-838.
21. Sarac, M. S., A. Cameron, and I. Lindberg. 2002. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect. Immun. 70:7136-7139.
22. Singh, Y., K. R. Klimpel, S. Goel, P. K. Swain, and S. H. Leppla. 1999. Oligomerization of anthrax toxin protective antigen and binding of lethal factor during endocytic uptake into mammalian cells. Infect. Immun. 67:1853-1859.
23. Soelaiman, S., B. Q. Wei, P. Bergson, Y. S. Lee, Y. Shen, M. Mrksich, B. K. Scholchet, and W. J. Tang. 2003. Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough. J. Biol. Chcm. 278:25990-25997.
24. Tonello, F., M. Seveso, O. Marin, M. Mock, and C. Montecucco. 2002. Screening inhibitors of anthrax lethal factor. Nature 418:386.
25. Welkos, S. L., T. J. Keener, and P. H. Gibbs. 1986. Differences in susceptibility of inbred mice to Bacillus anthracis. Infect. Immun. 51:795-800.
26. Zhang, Y., Y. Kida, K. Kuwano, Y. Misumi, Y. Ikehara, and S. Arai. 2001. Role of furin in delivery of CTL epitope of an anthrax toxin-fusion protein. Microbiol. Immunol. 45:119-125.