2.4 Å resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor

Biochemistry

Volumn 42, Issue 22, 2003, Pages 6709-6718

  Holyoak, Todd ^a   Wilson, Mark A ^a   Fenn, Timothy D ^a   Kettner, Charles A ^b   Petsko, Gregory A ^a   Fuller, Robert S ^c   Ringe, Dagmar ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b DUPONT COMPANY   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; DEGRADATION; PROTEINS;

TWO-DOMAIN PROTEINS;

HORMONES;

ALANINE; ARGININE; BORONIC ACID DERIVATIVE; CALCIUM ION; FURIN; LYSINE; PROTEIN KEX2; PROTEINASE; SUBTILISIN; UNCLASSIFIED DRUG; AMINO ACID; CALCIUM; KEX2 PROTEIN, S CEREVISIAE; OLIGOPEPTIDE; PROTEINASE INHIBITOR; SACCHAROMYCES CEREVISIAE PROTEIN; SERINE PROTEINASE;

ARTICLE; BINDING SITE; COMPLEX FORMATION; ENZYME ACTIVE SITE; ENZYME DEGRADATION; EUKARYOTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN STRUCTURE; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ELECTRICITY; ENZYME SPECIFICITY; METABOLISM; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

EUKARYOTA;

AMINO ACID SEQUENCE; AMINO ACIDS; BINDING SITES; BORONIC ACIDS; CALCIUM; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; MODELS, MOLECULAR; OLIGOPEPTIDES; PROPROTEIN CONVERTASES; PROTEASE INHIBITORS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE PROTEINS; SUBSTRATE SPECIFICITY; SUBTILISINS;

EID: 0037647026     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034434t     Document Type: Article

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