Quickening the pace of anthrax research: Three advances point towards possible therapies

Trends in Microbiology

Volumn 10, Issue 2, 2002, Pages 58-62

  Chaudry, G Jilani ^a   Moayeri, Mahtab ^a   Liu, Shihui ^a   Leppla, Stephen H ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX TOXIN;

ANTHRAX; BACILLUS ANTHRACIS; CRYSTAL STRUCTURE; DRUG MECHANISM; ENZYME INHIBITION; GENE MUTATION; GENETIC SUSCEPTIBILITY; MEDICAL RESEARCH; NONHUMAN; PARASITE VIRULENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; REVIEW;

ADENYLATE CYCLASE; ANIMALS; ANTHRAX; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; KINESIN; MICE; MODELS, MOLECULAR; MUTATION; PROTEASE INHIBITORS; RECEPTORS, PEPTIDE;

ANIMALIA; ANTHRAX; BACILLUS ANTHRACIS; POSIBACTERIA;

EID: 0036468526     PISSN: 0966842X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-842X(01)02294-6     Document Type: Review

References (26)

1. Anthrax toxin
2. Anthrax toxin edema factor: A bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells
3. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
4. Characterization of macrophage sensitivity and resistance to anthrax lethal toxin
5. Anthrax protective antigen interacts with a specific receptor on the surface of CHO-K1 cells
6. Identification of the cellular receptor for anthrax toxin
7. Evidence for variation in the number of functional gene copies at the AmaR locus in Chinese hamster cell lines
8. Residues 1-254 of anthrax toxin lethal factor are sufficient to cause cellular uptake of fused polypeptides
9. Genes expressed in human tumor endothelium
10. Cell surface tumor endothelial markers are conserved in mice and humans
11. Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin
12. Crystal structure of the anthrax lethal factor
13. Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex
14. Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages
15. Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process
16. On the role of macrophages in anthrax
17. Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor
18. Differences in susceptibility of inbred mice to Bacillus anthracis
19. Pathogenesis and genetic control of resistance to the Sterne strain of Bacillus anthracis
20. Basis of cellular sensitivity and resistance to anthrax lethal toxin
21. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11
22. Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11
23. Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor
24. Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum
25. The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family
26. VMD: Visual molecular dynamics