α1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: Application as an antipathogenic agent

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 13, 1998, Pages 7293-7298

  Jean, François ^a   Stella, Kori ^a   Thomas, Laurel ^a   Liu, Gseping ^a   Xiang, Yang ^a   Reason, Andrew J ^b   Thomas, Gary ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b M Scan Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; ALPHA 1 ANTITRYPSIN PORTLAND; FURIN; PROTEINASE INHIBITOR; PSEUDOMONAS EXOTOXIN; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; ALPHA 1-ANTITRYPSIN PORTLAND; ANTIINFECTIVE AGENT; BACTERIAL TOXIN; EXOTOXIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; RECOMBINANT PROTEIN; SUBTILISIN; TOXA PROTEIN, PSEUDOMONAS AERUGINOSA; VIRULENCE FACTOR;

ARTICLE; BIOENGINEERING; CELL KILLING; CYTOTOXICITY; ENZYMATIC ASSAY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PSEUDOMONAS; STOICHIOMETRY; CHEMICAL STRUCTURE; DRUG ANTAGONISM; ENZYME SPECIFICITY; GENETICS; HUMAN; KINETICS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PSEUDOMONAS AERUGINOSA;

ADP RIBOSE TRANSFERASES; ALPHA 1-ANTITRYPSIN; ANTI-BACTERIAL AGENTS; BACTERIAL TOXINS; EXOTOXINS; FURIN; HUMANS; KINETICS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PSEUDOMONAS AERUGINOSA; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; SUBTILISINS; VIRULENCE FACTORS;

EID: 0032560449     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.13.7293     Document Type: Article

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