Optimization of protease-inhibitor interactions by randomizing adventitious contacts

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 14, 2003, Pages 8205-8210

  Komiyama, Tomoko ^a   VanderLugt, Bryan ^a   Fugère, Martin ^b   Day, Robert ^b   Kaufman, Randal J ^a   Fuller, Robert S ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

EGLIN C; ENZYME; FURIN; PROTEIN KEX 2; PROTEIN PC 7; PROTEINASE INHIBITOR; SUBTILISIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL CULTURE; CELL STRAIN COS1; CHEMICAL MODIFICATION; CONTROLLED STUDY; CULTURE MEDIUM; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; ENZYME INHIBITION; HYPOTHESIS; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; PROTEINASE INHIBITION; REACTION OPTIMIZATION; YEAST;

AMINO ACID SUBSTITUTION; ANIMALS; CERCOPITHECUS AETHIOPS; CODON; COS CELLS; CULTURE MEDIA; DRUG DESIGN; FURIN; GENE LIBRARY; HUMANS; LEECHES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROPROTEIN CONVERTASES; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SERPINS; SUBSTRATE SPECIFICITY; SUBTILISINS; VON WILLEBRAND FACTOR;

ANIMALIA; BACTERIA (MICROORGANISMS); HIRUDINIDA;

EID: 0037478705     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1032865100     Document Type: Article

References (28)

1. Steiner, D. F. (2001) in The Enzymes XXII, eds. Dalbey, R. E. & Sigman, D. S. (Academic, San Diego) pp. 163-198.
2. Rockwell, N. C. & Fuller, R. S. (2001) in The Enzymes XXII, eds. Dalbey, R. E. & Sigman, D. S. (Academic, San Diego), pp. 260-289.
3. Miller, C. J., Elliott, J. L. & Collier, R. J. (1999) Biochemistry 38, 10432-10441.
4. Hatta, M., Gao, P., Halfmann, P. & Kawaoka, Y. (2001) Science 293, 1840-1842.
5. Thomas, G. (2002) Nat. Rev. Mol. Cell Riol. 3, 753-766.
6. Roebroek, A. J. M., Ulmans, L., Pauli, I. G. L., Robertson, E. J., van Leuven, F., Van de Ven, W. J. M. & Constam, D. B. (1998) Development (Cambridge, U.K.) 125, 4863-4876.
7. Spence, M. J., Sucic, J. F., Foley, B. T. & Moehring, T. J. (1995) Somatic Cell Mol. Genet. 21, 1-18.
8. Takahashi, S., Kasai, K., Hatsuzawa, K., Kitamura, N., Misumi, Ikehara, Y., Murakami, K. & Nakayama, K. (1993) Biochem. Biophys. Res. Commun. 195, 1019-1026.
9. Sarac, M. S., Cameron, A. & Lindberg, I. (2002) Infect. Immun. 70, 7136-7139.
10. Rockwell, N. C., Krysan, D. J., Komiyama, T. & Fuller, R. S. (2002) Chem. Rev. 102, 4525-4548.
11. Komiyama, T. & Fuller, R. S. (2000) Biochemistry 39, 15156-15156.
12. Schechter, I. & Berger, A. (1967) Biochem. Biophys. Res. Commun. 27, 157-162.
13. Siezen, R. J. & Leunissen, J. A. M. (1997) Protein Sci. 6, 501-523.
14. Bode, W. & Huber, R. (2000) Biochim. Biophys. Acta 1477, 241-252.
15. Bode, W., Papapamokos, E., Musil, D. & Seemuller, U. (1986) EMBO J. 5, 813-818.
16. Brenner, C. & Fuller, R. S. (1992) Proc. Natl. Acad. Sci. USA 89, 922-926.
17. Fugere, M., Limperis, P. C., Beaulleu-Audy, V., Gagnon, F., Vavigne, P., Klaskov, K., Leduc, R. & Day, R. (2002) J. Biol. Chem. 277, 7648-7656.
18. Bravo, D. A., Gleason, J. B., Sanchez, R. I., Roth, R. A. & Fuller, R. S. (1994) J. Biol. Chem. 269, 25830-25837.
19. Wise, R. J., Wong, P. A., Kiefer, M. C., Brake, A. J. & Kaufman, R. J. (1990) Proc. Natl. Acad. Sci. USA 87, 9378-9382.
20. Inoue, H., Nojima, H. & Okayama, H. (1990) Gene 96, 23-38.
21. Vazquez-Laslop, N., Lee, H., Hu, R. & Neyfakh, A. (2001) J. Bacteriol. 183, 2399-2404.
22. Dorner, A. J. & Kaufman, R. J. (1990) Methods Enzymol. 185, 577-596.
23. Rehemtulla, A. & Kaufman, R. J. (1992) Blood 79, 2349-2355.
24. Sun, J., Whisstock, J. C., Harriott, P., Walker, B., Novak, A., Thompson, P. E., Smith, A. I. & Bird, P. I. (2001) J. Biol. Chem. 276, 15177-15184.
25. Jean, F., Stella, K., Thomas, L., Liu, G., Xiang, Y., Reason, A. & Thomas, G. (1998) Proc. Natl. Acad. Sci. USA 95, 7293-7298.
26. Band, A. M., Maatta, J., Kaariainen, L. & Kuismanen, E. (2001) FEBS Lett. 505, 118-124.
27. Garten, W., Stieneke, A., Shaw, E., Wikstrom, P. Q. & Klenk, H. D. (1989) Virology 172, 25-31.
28. Richardson, D. C. & Richardson, J. S. (1992) Protein Sci. 1, 3-9.