메뉴 건너뛰기




Volumn 8, Issue 5, 2005, Pages 590-600

Creating the next generation of protein therapeutics through rational drug design

Author keywords

Biopharmaceuticals; Biotherapeutics; High throughput screening; Medicinal biology; Monoclonal antibodies; Protein design; Protein engineering

Indexed keywords

ABCIXIMAB; ADALIMUMAB; ALEFACEPT; ALEMTUZUMAB; ALPHA 1 ANTITRYPSIN; ASPARAGINASE MACROGOL; BASILIXIMAB; BEVACIZUMAB; CETUXIMAB; CONSENSUS INTERFERON; DACLIZUMAB; ETANERCEPT; IBRITUMOMAB TIUXETAN; IMIGLUCERASE; IMMUNOGLOBULIN ANTIBODY; INFLIXIMAB; INSULIN ASPART; INSULIN GLARGINE; INSULIN GLULISINE; INSULIN LISPRO; INTERFERON BETA SERINE; MONOCLONAL ANTIBODY; NATALIZUMAB; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; OMALIZUMAB; PALIVIZUMAB; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; PEGVISOMANT; RECOMBINANT BLOOD CLOTTING FACTOR 8; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 2; RECOMBINANT PROTEIN; RETEPLASE; TENECTEPLASE; TOSITUMOMAB I 131; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; XMAB;

EID: 24044442890     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (47)

References (77)
  • 1
    • 0043208919 scopus 로고    scopus 로고
    • Biopharmaceutical benchmarks - 2003
    • Walsh G: Biopharmaceutical benchmarks - 2003. Nat Biotechnol (2003) 21(8):865-870.
    • (2003) Nat Biotechnol , vol.21 , Issue.8 , pp. 865-870
    • Walsh, G.1
  • 2
    • 0142121432 scopus 로고    scopus 로고
    • Trends in development and approval times for new therapeutics in the United States
    • Relchert JM: Trends in development and approval times for new therapeutics in the United States. Nat Rev Drug Discov (2003) 2(9):695-702.
    • (2003) Nat Rev Drug Discov , vol.2 , Issue.9 , pp. 695-702
    • Relchert, J.M.1
  • 3
    • 11144334098 scopus 로고    scopus 로고
    • Recombinant protein therapeutics - Success rates, market trends and values to 2010
    • Pavlou AK, Reichert JM: Recombinant protein therapeutics - success rates, market trends and values to 2010. Nat Biotechnol (2004) 22(12):1513-1519. Provides a comprehensive overview of the global market for protein drugs, including overall sales by therapy area, by product and by company, with recent historical data plus a six-year forecast.
    • (2004) Nat Biotechnol , vol.22 , Issue.12 , pp. 1513-1519
    • Pavlou, A.K.1    Reichert, J.M.2
  • 5
    • 0037267313 scopus 로고    scopus 로고
    • Knockouts model the 100 best-selling drugs - Will they model the next 100?
    • Zambrowicz BP, Sands AT: Knockouts model the 100 best-selling drugs - will they model the next 100? Nat Rev Drug Discov (2003) 2(1):38-51.
    • (2003) Nat Rev Drug Discov , vol.2 , Issue.1 , pp. 38-51
    • Zambrowicz, B.P.1    Sands, A.T.2
  • 6
    • 0033105782 scopus 로고    scopus 로고
    • Anti-CD20 monoclonal antibodies as novel treatments for non-Hodgkin's lymphoma
    • White CA, Larocca A, Grillo-Lopez AJ: Anti-CD20 monoclonal antibodies as novel treatments for non-Hodgkin's lymphoma. Pharm Sci Technol Today (1999) 2(3):95-101.
    • (1999) Pharm Sci Technol Today , vol.2 , Issue.3 , pp. 95-101
    • White, C.A.1    Larocca, A.2    Grillo-Lopez, A.J.3
  • 7
    • 0036796192 scopus 로고    scopus 로고
    • Zevalin: The first radioimmunotherapy approved for the treatment of lymphoma
    • Grillo-Lopez AJ: Zevalin: The first radioimmunotherapy approved for the treatment of lymphoma. Expert Rev Anticancer Therapy (2002) 2(5):485-493.
    • (2002) Expert Rev Anticancer Therapy , vol.2 , Issue.5 , pp. 485-493
    • Grillo-Lopez, A.J.1
  • 8
    • 1042309456 scopus 로고    scopus 로고
    • Iodine-131 tositumomab (Bexxar): Radioimmunoconjugate therapy for indolent and transformed B-cell non-Hodgkin's lymphoma
    • Friedberg JW, Fisher RI: Iodine-131 tositumomab (Bexxar): Radioimmunoconjugate therapy for indolent and transformed B-cell non-Hodgkin's lymphoma. Expert Rev Anticancer Therapy (2004) 4(1):18-26.
    • (2004) Expert Rev Anticancer Therapy , vol.4 , Issue.1 , pp. 18-26
    • Friedberg, J.W.1    Fisher, R.I.2
  • 10
    • 0037458084 scopus 로고    scopus 로고
    • Optimization of protein therapeutics by directed evolution
    • Vasserot AP, Dickinson CD, Tang Y, Huse WD, Manchester KS, Watkins JD: Optimization of protein therapeutics by directed evolution. Drug Disc Today (2003) 8(3):118-126. Provides a good overview of codon-based and other mutagenesis techniques to generate protein library diversity ('directed evolution').
    • (2003) Drug Disc Today , vol.8 , Issue.3 , pp. 118-126
    • Vasserot, A.P.1    Dickinson, C.D.2    Tang, Y.3    Huse, W.D.4    Manchester, K.S.5    Watkins, J.D.6
  • 12
    • 0037231533 scopus 로고    scopus 로고
    • Adalimumab, a fully human anti-tumor necrosis factor α monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: The ARMADA trial
    • Weinblatt ME, Keystone EC, Furst DE, Moreland LW, Weisman MH, Birbara CA, Teoh LA, Fischkoff SA, Chartash EK: Adalimumab, a fully human anti-tumor necrosis factor α monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: The ARMADA trial. Arthritis Rheum (2003) 48(1):35-45.
    • (2003) Arthritis Rheum , vol.48 , Issue.1 , pp. 35-45
    • Weinblatt, M.E.1    Keystone, E.C.2    Furst, D.E.3    Moreland, L.W.4    Weisman, M.H.5    Birbara, C.A.6    Teoh, L.A.7    Fischkoff, S.A.8    Chartash, E.K.9
  • 13
    • 0037059061 scopus 로고    scopus 로고
    • Combining computational and experimental screening for rapid optimization of protein properties
    • Hayes RJ, Bentzien J, Ary ML, Hwang MY, Jacinto JM, Vielmetter J, Kundu A, Dahiyat BI: Combining computational and experimental screening for rapid optimization of protein properties. Proc Natl Acad Sci USA (2002) 99(25):15926-15931. Description of a general protein optimization strategy incorporating structure-based computational screening and high-throughput expression and activity assays of a large protein library.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.25 , pp. 15926-15931
    • Hayes, R.J.1    Bentzien, J.2    Ary, M.L.3    Hwang, M.Y.4    Jacinto, J.M.5    Vielmetter, J.6    Kundu, A.7    Dahiyat, B.I.8
  • 14
    • 0037161638 scopus 로고    scopus 로고
    • Recombinant interleukin-2 (rlL-2), aldesleukin
    • Baigent G: Recombinant interleukin-2 (rlL-2), aldesleukin. J Biotechnol (2002) 95(3):277-280.
    • (2002) J Biotechnol , vol.95 , Issue.3 , pp. 277-280
    • Baigent, G.1
  • 15
    • 19244382379 scopus 로고    scopus 로고
    • Multiple sclerosis and Interferon β-1b, past, present and future
    • Horowski R: Multiple sclerosis and Interferon β-1b, past, present and future. Clin Neurol Neurosurg (2002) 104(3):259-264.
    • (2002) Clin Neurol Neurosurg , vol.104 , Issue.3 , pp. 259-264
    • Horowski, R.1
  • 16
    • 0036713917 scopus 로고    scopus 로고
    • Rational cytokine design for increased lifetime and enhanced potency using pH-activated "histidine switching"
    • Sarkar CA, Lowenhaupt K, Horan T, Boone TC, Tidor B, Lauffenburger DA: Rational cytokine design for increased lifetime and enhanced potency using pH-activated "histidine switching" Nat Biotechnol (2002) 20(9):908-913. Discusses the use of surface engineering to improve half-life by inducing efficient endosomal recycling. Suggests a broadly applicable new approach to improve the pharmacokinetics of protein drugs.
    • (2002) Nat Biotechnol , vol.20 , Issue.9 , pp. 908-913
    • Sarkar, C.A.1    Lowenhaupt, K.2    Horan, T.3    Boone, T.C.4    Tidor, B.5    Lauffenburger, D.A.6
  • 21
    • 4644360094 scopus 로고    scopus 로고
    • Insulin aspart: A review of its use in the management of type 1 or 2 diabetes mellitus
    • Reynolds NA, Wagstaff AJ: Insulin aspart: A review of its use in the management of type 1 or 2 diabetes mellitus. Drugs (2004) 64(17):1957-1974.
    • (2004) Drugs , vol.64 , Issue.17 , pp. 1957-1974
    • Reynolds, N.A.1    Wagstaff, A.J.2
  • 22
    • 0346724642 scopus 로고    scopus 로고
    • Insulin glargine: Long-acting basal insulin analog for improved metabolic control
    • Gerich JE: Insulin glargine: Long-acting basal insulin analog for improved metabolic control. Curr Med Res Opin (2004) 20(1):31-37.
    • (2004) Curr Med Res Opin , vol.20 , Issue.1 , pp. 31-37
    • Gerich, J.E.1
  • 23
    • 0036464719 scopus 로고    scopus 로고
    • Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene
    • Cartron G, Dacheux L, Salles G, Solal-Celigny P, Bardos P, Colombat P, Watier H: Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene. Blood (2002) 99(3):754-758.
    • (2002) Blood , vol.99 , Issue.3 , pp. 754-758
    • Cartron, G.1    Dacheux, L.2    Salles, G.3    Solal-Celigny, P.4    Bardos, P.5    Colombat, P.6    Watier, H.7
  • 24
    • 0035794194 scopus 로고    scopus 로고
    • High resolution mapping of the binding site on human IgGI for FcγRI, FcγRII, FcγRIII and FcRn and design of IgG1 variants with improved binding to the FcγR
    • Shields RL, Namenuk AK, Hong K, Meng YG, Rae J, Briggs J, Xie D, Lai J, Stadlen A, Li B, Fox JA et al: High resolution mapping of the binding site on human IgGI for FcγRI, FcγRII, FcγRIII and FcRn and design of IgG1 variants with improved binding to the FcγR. J Biol Chem (2001) 276(9):6591-6604. Demonstrates that antibody affinity for Fc receptors can be improved by amino acid engineering, translating into improved tumor cell-killing by Fc variants of Herceptin® therapeutic antibody.
    • (2001) J Biol Chem , vol.276 , Issue.9 , pp. 6591-6604
    • Shields, R.L.1    Namenuk, A.K.2    Hong, K.3    Meng, Y.G.4    Rae, J.5    Briggs, J.6    Xie, D.7    Lai, J.8    Stadlen, A.9    Li, B.10    Fox, J.A.11
  • 25
    • 0031933840 scopus 로고    scopus 로고
    • Strategies for selection of antibodies by phage display
    • Griffiths AD, Duncan AR: Strategies for selection of antibodies by phage display. Curr Opin Biotechnol (1998) 9(1):102-108.
    • (1998) Curr Opin Biotechnol , vol.9 , Issue.1 , pp. 102-108
    • Griffiths, A.D.1    Duncan, A.R.2
  • 26
    • 0036900286 scopus 로고    scopus 로고
    • Antibody discovery: The use of transgenic mice to generate human monoclonal antibodies for therapeutics
    • Kellermann SA, Green LL: Antibody discovery: The use of transgenic mice to generate human monoclonal antibodies for therapeutics. Curr Opin Biotechnol (2002) 13(6):593-597.
    • (2002) Curr Opin Biotechnol , vol.13 , Issue.6 , pp. 593-597
    • Kellermann, S.A.1    Green, L.L.2
  • 27
    • 0030669930 scopus 로고    scopus 로고
    • Recombinant human tumor necrosis factor receptor (p75) Fc fusion protein (TNFR:Fc) in rheumatoid arthritis
    • Murray KM, Dahl SL: Recombinant human tumor necrosis factor receptor (p75) Fc fusion protein (TNFR:Fc) in rheumatoid arthritis. Ann Pharmacother (1997) 31(11):1335-1338.
    • (1997) Ann Pharmacother , vol.31 , Issue.11 , pp. 1335-1338
    • Murray, K.M.1    Dahl, S.L.2
  • 28
    • 2942733370 scopus 로고    scopus 로고
    • CTLA4Ig: A novel inhibitor of costimulation
    • Dall'Era M, Davis J: CTLA4Ig: A novel inhibitor of costimulation. Lupus (2004) 13(5):372-376.
    • (2004) Lupus , vol.13 , Issue.5 , pp. 372-376
    • Dall'Era, M.1    Davis, J.2
  • 29
    • 2942623843 scopus 로고    scopus 로고
    • A bispecific single-chain antibody fusion protein for targeted depletion of autoreactive B cells via unstimulated human T lymphocytes
    • Zocher M, Baeuerle PA: A bispecific single-chain antibody fusion protein for targeted depletion of autoreactive B cells via unstimulated human T lymphocytes. Mol Immunol (2004) 41(5):511-518. Discusses the design of a bispecific fusion, which specifically targets MOG-autoreactive B-cells by recruiting non-specific cytotoxic T-cells via the anti-CD3 antibody domain.
    • (2004) Mol Immunol , vol.41 , Issue.5 , pp. 511-518
    • Zocher, M.1    Baeuerle, P.A.2
  • 30
    • 3042795848 scopus 로고    scopus 로고
    • Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway
    • Bitonti AJ, Dumont JA, Low SC, Peters RT, Kropp KE, Palombella VJ, Stattel JM, Lu Y, Tan CA, Song JJ, Garcia AM et al: Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway. Proc Natl Acad Sci USA (2004) 101(26):9763-9768. Discusses the pulmonary delivery of erythropoietin enabled by conjugation to IgG1 to induce FcRn receptor-mediated transport across airway epithelium. Opens new possibilities for systemic delivery of large proteins through a non-invasive route.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.26 , pp. 9763-9768
    • Bitonti, A.J.1    Dumont, J.A.2    Low, S.C.3    Peters, R.T.4    Kropp, K.E.5    Palombella, V.J.6    Stattel, J.M.7    Lu, Y.8    Tan, C.A.9    Song, J.J.10    Garcia, A.M.11
  • 31
    • 0036787635 scopus 로고    scopus 로고
    • An efficient system for the evolution of aminoacyl-tRNA synthetase specificity
    • Santoro SW, Wang L, Herberich B, King DS, Schultz PG: An efficient system for the evolution of aminoacyl-tRNA synthetase specificity. Nat Biotechnol (2002) 20(10):1044-1048.
    • (2002) Nat Biotechnol , vol.20 , Issue.10 , pp. 1044-1048
    • Santoro, S.W.1    Wang, L.2    Herberich, B.3    King, D.S.4    Schultz, P.G.5
  • 32
    • 2942630608 scopus 로고    scopus 로고
    • Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
    • Zhang Z, Alfonta L, Tian F, Bursulaya B, Uryu S, King DS, Schultz PG: Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells. Proc Natl Acad Sci USA (2004) 101(24):8882-8887. Provides the first example of engineering a mammalian cell line (293T) to allow selective incorporation of an unnatural amino acid at a defined site.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.24 , pp. 8882-8887
    • Zhang, Z.1    Alfonta, L.2    Tian, F.3    Bursulaya, B.4    Uryu, S.5    King, D.S.6    Schultz, P.G.7
  • 33
    • 8344271025 scopus 로고    scopus 로고
    • Advances in the production of human therapeutic proteins in yeasts and filamentous fungi
    • Gemgross TU: Advances in the production of human therapeutic proteins in yeasts and filamentous fungi. Nat Biotechnol (2004) 22(11):1409-1414.
    • (2004) Nat Biotechnol , vol.22 , Issue.11 , pp. 1409-1414
    • Gemgross, T.U.1
  • 34
    • 1242341384 scopus 로고    scopus 로고
    • Expression systems for the production of recombinant pharmaceuticals
    • Sodoyer R: Expression systems for the production of recombinant pharmaceuticals. BioDrugs (2004) 18(1):51-62.
    • (2004) BioDrugs , vol.18 , Issue.1 , pp. 51-62
    • Sodoyer, R.1
  • 35
    • 1542291118 scopus 로고    scopus 로고
    • Posttranslational modification of therapeutic proteins in plants
    • Gomord V, Faye L: Posttranslational modification of therapeutic proteins in plants. Curr Opin Plant Biol (2004) 7(2):171-181.
    • (2004) Curr Opin Plant Biol , vol.7 , Issue.2 , pp. 171-181
    • Gomord, V.1    Faye, L.2
  • 36
    • 12244272391 scopus 로고    scopus 로고
    • Enhancement of therapeutic protein in vivo activities through glycoengineering
    • Elliott S, Lorenzini T, Asher S, Aoki K, Brankow D, Buck L, Busse L, Chang D, Fuller J, Grant J, Hernday N et al: Enhancement of therapeutic protein in vivo activities through glycoengineering. Nat Biotechnol (2003) 21(4):414-421. Introduction of additional N-linked carbohydrate chains into several unrelated proteins, showing that glycoengineering is a broadly applicable protein drug design tool.
    • (2003) Nat Biotechnol , vol.21 , Issue.4 , pp. 414-421
    • Elliott, S.1    Lorenzini, T.2    Asher, S.3    Aoki, K.4    Brankow, D.5    Buck, L.6    Busse, L.7    Chang, D.8    Fuller, J.9    Grant, J.10    Hernday, N.11
  • 37
    • 1942457733 scopus 로고    scopus 로고
    • Structural requirements for additional N-linked carbohydrate on recombinant human erythropoietin
    • Elliott S, Chang D, Delorme E, Eris T, Lorenzini T: Structural requirements for additional N-linked carbohydrate on recombinant human erythropoietin. J Biol Chem (2004) 279(16):16854-16862.
    • (2004) J Biol Chem , vol.279 , Issue.16 , pp. 16854-16862
    • Elliott, S.1    Chang, D.2    Delorme, E.3    Eris, T.4    Lorenzini, T.5
  • 38
    • 0033044588 scopus 로고    scopus 로고
    • Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity
    • Umaña P, Jean-Mairet J, Moudry R, Amstutz H, Bailey JE: Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity. Nat Biotechnol (1999) 17(2):176-180.
    • (1999) Nat Biotechnol , vol.17 , Issue.2 , pp. 176-180
    • Umaña, P.1    Jean-Mairet, J.2    Moudry, R.3    Amstutz, H.4    Bailey, J.E.5
  • 39
    • 0037474276 scopus 로고    scopus 로고
    • The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity
    • Shinkawa T, Nakamura K, Yamane N, Shoji-Hosaka E, Kanda Y, Sakurada M, Uchida K, Anazawa H, Satoh M, Yamasaki M, Hanai N et al: The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity. J Biol Chem (2003) 278(5):3466-3473. Describes a glycoform engineering approach to improving tumor-killing effector function of antibodies.
    • (2003) J Biol Chem , vol.278 , Issue.5 , pp. 3466-3473
    • Shinkawa, T.1    Nakamura, K.2    Yamane, N.3    Shoji-Hosaka, E.4    Kanda, Y.5    Sakurada, M.6    Uchida, K.7    Anazawa, H.8    Satoh, M.9    Yamasaki, M.10    Hanai, N.11
  • 40
    • 8344224534 scopus 로고    scopus 로고
    • Characterizing biological products and assessing comparability following manufacturing changes
    • Chirino AJ, Mire-Sluis A: Characterizing biological products and assessing comparability following manufacturing changes. Nat Biotechnol (2004) 22(11):1383-1391. Provides a good overview of strategies to predict, detect and reduce the immunogenicity of protein drugs prior to clinical development.
    • (2004) Nat Biotechnol , vol.22 , Issue.11 , pp. 1383-1391
    • Chirino, A.J.1    Mire-Sluis, A.2
  • 42
    • 4644301510 scopus 로고    scopus 로고
    • Conjugates of peptides and proteins to polyethylene glycols
    • Morpurgo M, Veronese FM: Conjugates of peptides and proteins to polyethylene glycols. Methods Mol Biol (2004) 283:45-70.
    • (2004) Methods Mol Biol , vol.283 , pp. 45-70
    • Morpurgo, M.1    Veronese, F.M.2
  • 43
    • 0035086519 scopus 로고    scopus 로고
    • Rational design of a potent, long-lasting form of interferon: A 40 kDa branched polyethylene glycol-conjugated interferon α-2a for the treatment of hepatitis C
    • Bailon P, Palleroni A, Schaffer CA, Spence CL, Fung WJ, Porter JE, Ehrlich GK, Pan W, Xu ZX, Modi MW, Farid A et al: Rational design of a potent, long-lasting form of interferon: A 40 kDa branched polyethylene glycol-conjugated interferon α-2a for the treatment of hepatitis C. Bioconjug Chem (2001) 12(2):195-202. Provides an example of how pegylation improves pharmacokinetics while reducing drug potency, and also describes the pegylation of IFNα-2a (Roferon®-A) to create a new drug (Pegasys®) with an improved serum half-life, yet with substantial loss of in vitro antiviral activity.
    • (2001) Bioconjug Chem , vol.12 , Issue.2 , pp. 195-202
    • Bailon, P.1    Palleroni, A.2    Schaffer, C.A.3    Spence, C.L.4    Fung, W.J.5    Porter, J.E.6    Ehrlich, G.K.7    Pan, W.8    Xu, Z.X.9    Modi, M.W.10    Farid, A.11
  • 44
    • 0141757326 scopus 로고    scopus 로고
    • Inactivation of TNF signaling by rationally designed dominant-negative TNF variants
    • Steed PM, Tansey MG, Zalevsky J, Zhukovsky EA, Desjarlais JR, Szymkowski DE, Abbott C, Carmichael D, Chan C, Cherry L, Cheung P et al: Inactivation of TNF signaling by rationally designed dominant-negative TNF variants. Science (2003) 301(5641):1895-1898. Exemplifies a new mechanism to antagonize TNF signaling via subunit exchange of inactive TNF variant with bioactive native cytokine, combined with structure-guided site-directed pegylation to maintain compound activity.
    • (2003) Science , vol.301 , Issue.5641 , pp. 1895-1898
    • Steed, P.M.1    Tansey, M.G.2    Zalevsky, J.3    Zhukovsky, E.A.4    Desjarlais, J.R.5    Szymkowski, D.E.6    Abbott, C.7    Carmichael, D.8    Chan, C.9    Cherry, L.10    Cheung, P.11
  • 45
    • 0035760892 scopus 로고    scopus 로고
    • Thrombocytopenia caused by the development of antibodies to thrombopoietin
    • Li J, Yang C, Xia Y, Bertino A, Glaspy J, Roberts M, Kuter DJ: Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood (2001) 98(12):3241-3248.
    • (2001) Blood , vol.98 , Issue.12 , pp. 3241-3248
    • Li, J.1    Yang, C.2    Xia, Y.3    Bertino, A.4    Glaspy, J.5    Roberts, M.6    Kuter, D.J.7
  • 46
    • 0038351870 scopus 로고    scopus 로고
    • Antibody-targeted chemotherapy of acute myeloid leukemia using gemtuzumab ozogamicin (Mylotarg)
    • Sievers EL: Antibody-targeted chemotherapy of acute myeloid leukemia using gemtuzumab ozogamicin (Mylotarg). Blood Cells Mol Dis (2003) 31(1):7-10.
    • (2003) Blood Cells Mol Dis , vol.31 , Issue.1 , pp. 7-10
    • Sievers, E.L.1
  • 47
    • 0029383734 scopus 로고
    • Targeting diphtheria toxin to growth factor receptors
    • Murphy JR, vanderSpek JC: Targeting diphtheria toxin to growth factor receptors. Semin Cancer Biol (1995) 6(5):259-267.
    • (1995) Semin Cancer Biol , vol.6 , Issue.5 , pp. 259-267
    • Murphy, J.R.1    VanderSpek, J.C.2
  • 48
    • 0033305719 scopus 로고    scopus 로고
    • The human growth hormone antagonist B2036 does not interact with the prolactin receptor
    • Goffin V, Bernichtein S, Carriere O, Bennett WF, Kopchick JJ, Kelly PA: The human growth hormone antagonist B2036 does not interact with the prolactin receptor. Endocrinology (1999) 140(8):3853-3856. Provides an example of a marketed drug (Somavert®) engineered to introduce two novel functions: transformation of HGH into a GHR antagonist, and elimination of drug binding to PRLR to avoid potential side effects.
    • (1999) Endocrinology , vol.140 , Issue.8 , pp. 3853-3856
    • Goffin, V.1    Bernichtein, S.2    Carriere, O.3    Bennett, W.F.4    Kopchick, J.J.5    Kelly, P.A.6
  • 49
    • 4243193692 scopus 로고    scopus 로고
    • An engineered cocaine hydrolase blunts and reverses cardiovascular responses to cocaine in rats
    • Gao Y, Brimijoin S: An engineered cocaine hydrolase blunts and reverses cardiovascular responses to cocaine in rats. J Pharmacol Exp Ther (2004) 310(3):1046-1052. Discusses the engineering of human plasma BChE with two amino acid changes for greater cocaine hydrolysis activity. The engineered enzyme provided increased cocaine clearance in rats.
    • (2004) J Pharmacol Exp Ther , vol.310 , Issue.3 , pp. 1046-1052
    • Gao, Y.1    Brimijoin, S.2
  • 50
    • 3042725549 scopus 로고    scopus 로고
    • Derivatives of erythropoietin that are tissue protective but not erythropoietic
    • Leist M, Ghezzi P, Grasso G, Bianchi R, Villa P, Fratelli M, Savino C, Bianchi M, Nielsen J, Gerwien J, Kallunki P et al: Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science (2004) 305(5681):239-242. Demonstrates the ability to engineer novel properties into a cytokine (elimination of binding to the classical erythropoietin receptor while maintaining a desired secondary activity), even when the receptor involved in the desired function is unknown.
    • (2004) Science , vol.305 , Issue.5681 , pp. 239-242
    • Leist, M.1    Ghezzi, P.2    Grasso, G.3    Bianchi, R.4    Villa, P.5    Fratelli, M.6    Savino, C.7    Bianchi, M.8    Nielsen, J.9    Gerwien, J.10    Kallunki, P.11
  • 51
    • 0037423148 scopus 로고    scopus 로고
    • Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein
    • Kochendoerfer GG, Chen SY, Mao F, Cressman S, Traviglia S, Shao H, Hunter CL, Low DW, Cagle EN, Carnevali M, Gueriguian V et al: Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein. Science (2003) 299(5608):884-887. Presents the total chemical synthesis of an engineered erythropoietin-like protein of 166 amino acids conjugated to a defined polymer. The modified protein demonstrated in vivo erythropoietic activity.
    • (2003) Science , vol.299 , Issue.5608 , pp. 884-887
    • Kochendoerfer, G.G.1    Chen, S.Y.2    Mao, F.3    Cressman, S.4    Traviglia, S.5    Shao, H.6    Hunter, C.L.7    Low, D.W.8    Cagle, E.N.9    Carnevali, M.10    Gueriguian, V.11
  • 52
    • 2642516236 scopus 로고    scopus 로고
    • Exubera inhaled insulin: A review
    • Barnett AH: Exubera inhaled insulin: A review. Int J Clin Pract (2004) 58(4):394-401.
    • (2004) Int J Clin Pract , vol.58 , Issue.4 , pp. 394-401
    • Barnett, A.H.1
  • 53
    • 0842304936 scopus 로고    scopus 로고
    • Minimizing the immunogenicity of protein therapeutics
    • Chirino AJ, Ary ML, Marshall SA: Minimizing the immunogenicity of protein therapeutics. Drug Disc Today (2004) 9(2):82-90.
    • (2004) Drug Disc Today , vol.9 , Issue.2 , pp. 82-90
    • Chirino, A.J.1    Ary, M.L.2    Marshall, S.A.3
  • 54
    • 0036433382 scopus 로고    scopus 로고
    • Rationally engineered proteins or antibodies with absent or reduced immunogenicity
    • Tangri S, LiCalsi C, Sidney J, Sette A: Rationally engineered proteins or antibodies with absent or reduced immunogenicity. Curr Med Chem (2002) 9(24):2191-2199.
    • (2002) Curr Med Chem , vol.9 , Issue.24 , pp. 2191-2199
    • Tangri, S.1    LiCalsi, C.2    Sidney, J.3    Sette, A.4
  • 55
    • 4143076925 scopus 로고    scopus 로고
    • Engineering thermostability in serine protease inhibitors
    • Im H, Ryu MJ, Yu MH: Engineering thermostability in serine protease inhibitors. Protein Eng Des Sel (2004) 17(4):325-331.
    • (2004) Protein Eng des Sel , vol.17 , Issue.4 , pp. 325-331
    • Im, H.1    Ryu, M.J.2    Yu, M.H.3
  • 56
    • 0242490139 scopus 로고    scopus 로고
    • Insulin glulisine
    • Aventis Pharma
    • Barlocco D: Insulin glulisine. Aventis Pharma. Curr Opin Invest Drugs (2003) 4(10):1240-1244.
    • (2003) Curr Opin Invest Drugs , vol.4 , Issue.10 , pp. 1240-1244
    • Barlocco, D.1
  • 57
    • 0029833999 scopus 로고    scopus 로고
    • The biologic activity and molecular characterization of a novel synthetic interferon-α species, consensus interferon
    • Blatt LM, Davis JM, Klein SB, Taylor MW: The biologic activity and molecular characterization of a novel synthetic interferon-α species, consensus interferon. J Interferon Cytokine Res (1996) 16(7):489-499.
    • (1996) J Interferon Cytokine Res , vol.16 , Issue.7 , pp. 489-499
    • Blatt, L.M.1    Davis, J.M.2    Klein, S.B.3    Taylor, M.W.4
  • 58
    • 0034905963 scopus 로고    scopus 로고
    • Tenecteplase: A review
    • Davydov L, Cheng JW: Tenecteplase: A review. Clin Ther (2001) 23(7):982-997.
    • (2001) Clin Ther , vol.23 , Issue.7 , pp. 982-997
    • Davydov, L.1    Cheng, J.W.2
  • 60
    • 0030593897 scopus 로고    scopus 로고
    • Molecular biology of plasminogen activators: What are the clinical implications of drug design?
    • Smalling RW: Molecular biology of plasminogen activators: What are the clinical implications of drug design? Am J Cardiol (1996) 78(12A):2-7.
    • (1996) Am J Cardiol , vol.78 , Issue.12 A , pp. 2-7
    • Smalling, R.W.1
  • 62
    • 0034235955 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice
    • Overholser JP, Prewett MC, Hooper AT, Waksal HW, Hicklin DJ: Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice. Cancer (2000) 89(1):74-82.
    • (2000) Cancer , vol.89 , Issue.1 , pp. 74-82
    • Overholser, J.P.1    Prewett, M.C.2    Hooper, A.T.3    Waksal, H.W.4    Hicklin, D.J.5
  • 63
    • 0032771829 scopus 로고    scopus 로고
    • Infliximab: A novel chimeric monoclonal antibody for the treatment of Crohn's disease
    • Mouser JF, Hyams JS: Infliximab: A novel chimeric monoclonal antibody for the treatment of Crohn's disease. Clin Ther (1999) 21(6):932-942.
    • (1999) Clin Ther , vol.21 , Issue.6 , pp. 932-942
    • Mouser, J.F.1    Hyams, J.S.2
  • 65
    • 0033048519 scopus 로고    scopus 로고
    • Basiliximab
    • Onrust SV, Wiseman LR: Basiliximab. Drugs (1999) 57(2):207-213.
    • (1999) Drugs , vol.57 , Issue.2 , pp. 207-213
    • Onrust, S.V.1    Wiseman, L.R.2
  • 66
    • 0032135083 scopus 로고    scopus 로고
    • Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents
    • Lin KC, Castro AC: Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents. Curr Opin Chem Biol (1998) 2(4):453-457.
    • (1998) Curr Opin Chem Biol , vol.2 , Issue.4 , pp. 453-457
    • Lin, K.C.1    Castro, A.C.2
  • 67
    • 0033527584 scopus 로고    scopus 로고
    • Selection and analysis of an optimized anti-VEGF antibody: Crystal structure of an affinity-matured Fab in complex with antigen
    • Chen Y, Wiesmann C, Fuh G, Li B, Christinger HW, McKay P, de Vos AM, Lowman HB: Selection and analysis of an optimized anti-VEGF antibody: Crystal structure of an affinity-matured Fab in complex with antigen. J Mol Biol (1999) 293(4):865-881.
    • (1999) J Mol Biol , vol.293 , Issue.4 , pp. 865-881
    • Chen, Y.1    Wiesmann, C.2    Fuh, G.3    Li, B.4    Christinger, H.W.5    McKay, P.6    De Vos, A.M.7    Lowman, H.B.8
  • 68
    • 0021227678 scopus 로고
    • Elimination of graft-versus-host disease by in vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1)
    • Waldmann H, Polliak A, Hale G, Or R, Cividalli G, Weiss L, Weshler Z, Samuel S, Manor D, Brautbar C et al: Elimination of graft-versus-host disease by In vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1). Lancet (1984) 2(8401):483-486.
    • (1984) Lancet , vol.2 , Issue.8401 , pp. 483-486
    • Waldmann, H.1    Polliak, A.2    Hale, G.3    Or, R.4    Cividalli, G.5    Weiss, L.6    Weshler, Z.7    Samuel, S.8    Manor, D.9    Brautbar, C.10
  • 69
    • 0032895235 scopus 로고    scopus 로고
    • Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancer
    • Goldenberg MM: Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancer. Clin Ther (1999) 21(2):309-318.
    • (1999) Clin Ther , vol.21 , Issue.2 , pp. 309-318
    • Goldenberg, M.M.1
  • 70
    • 0032790024 scopus 로고    scopus 로고
    • Palivizumab
    • Scott LJ, Lamb HM: Palivizumab. Drugs (1999) 58(2):305-311.
    • (1999) Drugs , vol.58 , Issue.2 , pp. 305-311
    • Scott, L.J.1    Lamb, H.M.2
  • 71
    • 0035093479 scopus 로고    scopus 로고
    • Omalizumab
    • Easthope S, Jarvis B: Omalizumab. Drugs (2001) 61(2):253-260.
    • (2001) Drugs , vol.61 , Issue.2 , pp. 253-260
    • Easthope, S.1    Jarvis, B.2
  • 72
    • 0031786786 scopus 로고    scopus 로고
    • The use of antibodies against the IL-2 receptor in transplantation
    • Waldmann TA, O'Shea J: The use of antibodies against the IL-2 receptor in transplantation. Curr Opin Immunol (1998) 10(5):507-512.
    • (1998) Curr Opin Immunol , vol.10 , Issue.5 , pp. 507-512
    • Waldmann, T.A.1    O'Shea, J.2
  • 74
    • 0042820354 scopus 로고    scopus 로고
    • Pegylation of Interferon alfa: Structural and pharmacokinetic properties
    • Pedder SC: Pegylation of Interferon alfa: Structural and pharmacokinetic properties. Semin Liver Dis (2003) 23(Suppl 1):19-22.
    • (2003) Semin Liver Dis , vol.23 , Issue.SUPPL. 1 , pp. 19-22
    • Pedder, S.C.1
  • 75
    • 1842535270 scopus 로고    scopus 로고
    • The design and development of pegfilgrastim (PEG-rmetHuG-CSF, Neulasta)
    • Molineux G: The design and development of pegfilgrastim (PEG-rmetHuG-CSF, Neulasta). Curr Pharm Des (2004) 10(11):1235-1244.
    • (2004) Curr Pharm des , vol.10 , Issue.11 , pp. 1235-1244
    • Molineux, G.1
  • 76
    • 0042999388 scopus 로고    scopus 로고
    • Pegaspargase: A review of clinical studies
    • Graham ML: Pegaspargase: A review of clinical studies. Adv Drug Deliv Rev (2003) 55(10):1293-1302.
    • (2003) Adv Drug Deliv Rev , vol.55 , Issue.10 , pp. 1293-1302
    • Graham, M.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.