Optimized expression and specific activity of IL-12 by directed molecular evolution

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 3, 2003, Pages 1163-1168

  Leong, Steven R ^a   Chang, Jean C C ^a   Ong, Randal ^a   Dawes, Glenn ^a   Stemmer, Willem P C ^a   Punnonen, Juha ^a  

^a MAXYGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P35; PROTEIN P40; RECOMBINANT INTERLEUKIN 12; VACCINE;

AMINO ACID SUBSTITUTION; ARTICLE; ASSAY; CYTOKINE PRODUCTION; DNA SCREENING; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOGENICITY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; METASTASIS; MOLECULAR EVOLUTION; PRIORITY JOURNAL; SIDE EFFECT; T LYMPHOCYTE; TH1 CELL; TUMOR GROWTH;

AMINO ACID SEQUENCE; ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELLS, CULTURED; COS CELLS; DIMERIZATION; DIRECTED MOLECULAR EVOLUTION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE LIBRARY; GENETIC TECHNIQUES; GLYCOSYLATION; HUMANS; INTERLEUKIN-12; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; T-LYMPHOCYTES; TH1 CELLS; TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 0037417871     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0237327100     Document Type: Article

References (55)

1. Gately, M. K., Renzetti, L. M., Magram, J., Stern, A. S., Adorin, I. L., Gubler, U. & Presky, D. H. (1998) Annu. Rev. Immunol. 16, 495-521.
2. Trinchieri, G. & Scott, P. (1999) Curr. Top. Microbiol. Immunol. 238, 57-78.
3. Greenberger, M. J., Kunkel, S., Strieter, R., Lukacs, N., Bramson, J., Gauldie, J., Graham, F., Hitt, M., Danforth, J. & Standiford, T. (1966) J. Immunol. 157, 3006-3012.
4. Silva, R., Pais, T. & Appelberg, R. (1998) J. Immunol. 161, 5578-5585.
5. Miller, M., Skeen, M. & Ziegler, H. (1998) Cell Immunol. 184, 92-104.
6. Romani, L., Bistoni, F. & Puccetti, P. (1997) Chem. Immunol. 68, 110-135.
7. Kawakami, K., Tohyama, M., Xie, Q. & Saito, A. (1996) Clin. Exp. Immunol. 104, 208-214.
8. Mountford, A., Anderson, S. & Wilson, R. (1996) J. Immunol. 156, 4739-4745.
9. Kenney, R., Sacks, D., Sypek, J., Vilela, L., Gam, A. & Evans-Davis, K. (1999) J. Immunol. 163, 4481-4488.
10. Altare, F., Durandy, A., Lammas, D., Emile, J. F., Lamhamedi, S., Le Deist, F., Drysdale, P., Jouanguy, E., Doffinger, R., Bernaudin, F, et al. (1998) Science 280, 1432-1435.
11. Altare, F., Lammas, D., Revy, P., Jouanguy, E., Doffinger, R., Lamhamedi, S., Drysdale, P., Scheel-Toellner, D., Girdlestone, J., Darbyshire, P., et al. (1998) J. Clin. Invest. 102, 2035-2040.
12. de Jong, R., Altare, F., Haagen, I., Elferink, D., Boer, T., van Breda Vriesman, P., Kabel, P., Draaisma, J., can Dissel, J., et al. (1998) Science 280, 1435-1438.
13. Hensler, T., Heidecke, C., Hecker, H., Heeg, K., Bartels, H., Zantl, N., Wagner, H., Siewert, J. & Holmann, B. (1998) J. Immunol. 161, 2655-2659.
14. Haraguchi, S., Day, N., Nelson, R. J., Emmanuel, P., Duplantier, J., Christodoulou, C. & Good, R. (1998) Proc. Natl. Acad. Sci. USA 95, 13125-13129.
15. Lode, H., Dreier, T., Xiang, R., Varki, N., Kang, A. & Reisfeld, R. (1998) Proc. Natl. Acad. Sci. USA 95, 2475-2480.
16. Rook, A., Wood, G., Yoo, E., Elenitsas, R., Kao, D., Sherman, M., Witmer, W., Rockwell, K., Shane, R., Lessin, S. & Vonderheid, E. (1998) Blood 94, 902-908.
17. Presky, D., Minetti, L., Gillessen, S., Wilkinson, V., Wu, C., Gubler, U., Chizzonite, R. & Gately, M. (1998) J. Immunol. 160, 2174-2179.
18. Merberg, D., Wolf, S. & Clark, S. (1992) Immunol. Today 2, 77-78.
19. Gearing, D. & Cosman, D. (1991) Cell 66, 9-10.
20. Dwyer, D. (1996) J. Mol. Graphics 3, 148-157.
21. Devergnes, O., Birkenbach, M. & Kieff, E. (1997) Proc. Natl. Acad. Sci. USA 94, 12041-12046.
22. Ling, P., Gately, M., Gubler, U., Stern, A., Lin, P., Hollfelder, K., Su, C., Pan, Y.-C. & Hakimi, J. (1995) J. Immunol. 154, 116-127.
23. Oppmann, B., Lesley, R., Blom, B., Timas, J., Xu, Y., Hunte, B., Vega, F., Yu, N., Wang, J., Singh, K., et al. (2000) Immunity 5, 715-725.
24. Kang, W. K., Park, C., Yoon, H. L., Kim, W. S., Yoon, S. S., Lee, M. H., Park, K., Kim, K., Jeong, H. S., Kim, J. A., et al. (2001) Hum. Gene Ther. 12, 671-684.
25. Robertson, M. J., Cameron, C., Atkins, M. B., Gordon, M. S., Lotze, M. T., Sherman, M. L. & Ritz, J. (1999) Clin. Cancer Res. 5, 9-17.
26. Sun, Y., Jurgovsky, K., Moller, P., Alijagic, S., Dorbic, T., Georgieva, J., Wittig, B. & Schadendorf, D. (1998) Gene Ther. 5, 481-490.
27. Rakhmilevich, A., Timmins, J., Janssen, K., Pohlmann, E., Sheehy, M. & Yang, N. (1999) J. Immunother. 22, 135-144.
28. Rakhmilevich, A., Turner, J., Ford, M., McCabe, D., Sun, W., Sondel, P., Grota, K. & Yang, N.-S. (1996) Proc. Natl. Acad. Sci. USA 93, 6291-6296.
29. Chaplin, P., Camon, E., Villarreal-Ramos, B., Flint, M., Ryan, M. & Collins, R. (1999) J. Interferon Cytokine Res. 19, 235-241.
30. Stemmer, W. (1995) Biotechnology 13, 549-553.
31. Ness, J., Del Cardayre, S., Minshull, J. & Stemmer, W. (2000) Adv. Protein Chem. 55, 261-292.
32. Whalen, R. G., Kaiwar, R., Soong, N.-W. & Punnonen, J. (2001) Curr. Opin. Mol. Ther. 3, 31-36.
33. Powell, S., Kaloss, M., Pinkstaff, A., McKee, R., Burimski, I., Pensiero, M., Otto, E., Stemmer, W. & Soong, N.-W. (2000) Nat. Biotechnol. 18, 1279-1282.
34. Ness, J. E., Welch, M., Giver, L., Bueno, M., Cherry, J. R., Borchert, T. V., Stemmer, W. P. & Minshull, J. (1999) Nat. Biotechnol. 17, 893-896.
35. Lazetic, S., Leong, S. R., Chang, C.-C. J., Ong, R., Dawes, G. & Punnonen, J. (2002) J. Biol. Chem. 277, 38660-38668.
36. Chang, C.-C., Chen, T., Cox, B., Dawes, G., Stemmer, W., Punnonen, J. & Patten, P. (1999) Nat. Biotechnol. 17, 793-797.
37. Crameri, A., Railard, S., Bermudez, E. & Stemmer, W. (1998) Nature 391, 288-291.
38. Chang, C.-C., Wright, A. & Punnonen, J. (2000) J. Immunol. 165, 3584-3591.
39. Yssel, H., de Vries, J., Koken, M., Van Blitterswijk, W. & Spits, H. (1994) J. Immunol. Methods 72, 219-227.
40. Punnonen, J. & de Vries, J. (1994) J. Immunol. 152, 1094-1102.
41. Schoenhaut, D., Chua, A., Wolitzky, A., Quinn, P., Dwyer, C., McComas, W., Familletti, P., Gately, M. & Gubler, U. (1992) J. Immunol. 148, 3433-3440.
42. Reddy, A., Gibbs, B., Lui, Y., Coward, J., Changchien, L. & Maley, F. (1999) Glycobiology 9, 547-555.
43. Werner, R., Noe, W., Kopp, K. & Schluter, M. (1998) Arzneim.-Forsch. 48, 870-880.
44. Yoon, C., Johnston, S., Tang, J., Stahl, M., Tobin, J. & Somers, W. (2000) EMBO J. 19, 3530-3541.
45. Nadeau, R., Ostrowski, C., Ni-Wu, G. & Liberato, D. (1995) J. Pharmacol. Exp. Ther. 274, 78-83.
46. Sarmiento, U., Riley, J., Knaack, P., Lipman, J., Becker, J., Gately, M., Chizzonite, R. & Anderson, T. (1994) Lab. Invest. 71, 862-873.
47. Watanabe, N., Sypek, J., Mittler, S., Reimann, K., Flores-Villanueva, P., Voss, G., Lord, C. & Letvin, N. (1998) AIDS Res. Retroviruses 14, 393-399.
48. Atkins, M., Robertson, M., Gordon, M. S., Lotze, M., DeCoste, M., DuBois, J., Ritz, J., Sandier, A., Edington, H., Garzone, P., et al. (1997) Clin. Cancer Res. 3, 409-417.
49. Carreno, V., Zuezem, S., Hopf, U., Marcellin, P., Cooksley, W., Fevery, J., Diago, M., Reddy, R., Peters, M., Rittweger, K., et al. (2000) J. Hepatol. 32, 317-324.
50. Zuezem, S., Hopf, U., Carreno, V., Diago, M., Shiffman, M., Grune, S., Dudley, F., Rakhit, A., Rittweger, K., Yap, S., Koff, R. & Thomas, H. (1999) Hepatology 29, 1280-1287.
51. Zeisel, H., Lutz, A. & von Petrykowski, W. (1992) Horm. Res. 37, 47-55.
52. Vial, T. & Descotes, J. (1995) Toxiciology 105, 31-57.
53. Leong, S., DeForge, L., Presta, L., Gonzalez, T., Fan, A., Reichert, M., Chuntharapai, A., Kim, K., Tumas, D., Lee, W., et al. (2001) Cytokine 16, 106-119.
54. Cheng-Mayer, C., Brown, A., Harhouse, J., Luciw, P. & Mayer, A. (1999) J. Virol. 73, 5294-5300.
55. Kim, J., Ayyavoo, V., Bagarazzi, M., Chattergoon, M., Dang, K., Wang, B., Boyer, J. & Weiner, D. (1997) J. Immunol. 158, 816-826.