Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein

Science

Volumn 299, Issue 5608, 2003, Pages 884-887

  Kochendoerfer, Gerd G ^a   Chen, Shiah Yun ^a   Mao, Feng ^a   Cressman, Sonya ^a,c   Traviglia, Stacey ^a,d   Shao, Haiyan ^a   Hunter, Christie L ^a,e   Low, Donald W ^a,f   Cagle, E Neil ^a   Carnevali, Maia ^a   Gueriguian, Vincent ^a   Keogh, Peter J ^a   Porter, Heather ^a   Stratton, Stephen M ^a   Con Wiedeke, M ^a   Wilken, Jill ^a   Tang, Jie ^a,g   Levy, Jay J ^a,h   Miranda, Les P ^a   Crnogorac, Milan M ^a   Kalbag, Suresh ^a   Botti, Paolo ^a,h   Schindler Horvat, Janice ^a   Savatski, Laura ^b   Adamson, John W ^b   Kung, Ada ^a   Kent, Stephen B H ^a,i   Bradburne, James A ^a   more..

^a Gryphon Therapeutics   (United States)

^b BLOOD RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d Diosynth RTP Inc   (United States)

^e APPLIED BIOSYSTEMS   (United States)

^f CELERA   (United States)

^g Midwest Biotech   (United States)

^h Geneva Proteomics Inc   (Switzerland)

ⁱ UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; MACROMOLECULES; MASS SPECTROMETRY; POLYPEPTIDES; SYNTHESIS (CHEMICAL);

COVALENT STRUCTURE;

PROTEINS;

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; POLYMER; PROTEIN; RECOMBINANT PROTEIN; SYNTHETIC ERYTHROPOIESIS PROTEIN; UNCLASSIFIED DRUG;

POLYMER; PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; COVALENT BOND; DISULFIDE BOND; ERYTHROPOIESIS; HYDROPHILICITY; MACROMOLECULE; MASS SPECTROMETRY; PEPTIDE MAPPING; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CIRCULAR DICHROISM; DRUG DESIGN; DRUG STABILITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ERYTHROPOIESIS; ERYTHROPOIETIN; ERYTHROPOIETIN, RECOMBINANT; HEMATOCRIT; HUMANS; ISOELECTRIC POINT; MICE; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; POLYMERS; PROTEIN FOLDING; PROTEINS; RATS; RECEPTORS, ERYTHROPOIETIN; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

ANIMALIA;

EID: 0037423148     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1079085     Document Type: Article

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