Structural and functional characterization of B-domain deleted recombinant factor VIII

Seminars in Hematology

Volumn 38, Issue 2 SUPPL. 4, 2001, Pages 4-12

  Sandberg, H ^a   Almstedt, A ^a   Brandt, J ^a   Castro, V M ^a   Gray, E ^a   Holmquist, L ^a   Lewin, M ^a   Oswaldsson, U ^a   Mikaelsson, M ^a   Jankowski, M A ^a   Bond, M ^a   Scoble, H A ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 10A; RECOMBINANT BLOOD CLOTTING FACTOR 8; THROMBIN; VON WILLEBRAND FACTOR;

AMINO ACID SEQUENCE; DRUG ACTIVITY; DRUG STRUCTURE; HEMOPHILIA A; HUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; REVIEW; STRUCTURE ANALYSIS;

EID: 0034964581     PISSN: 00371963     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0037-1963(01)90103-9     Document Type: Review

References (19)

1. Molecular cloning of a cDNA encoding human antihaemophilic factor
2. Characterization of the human factor VIII gene
3. Structure of human factor VIII
4. Expression of active human factor VIII from recombinant DNA clones
5. The life cycle of coagulation factor VIII in view of its structure and function
6. Isolation and characterization of human factor VIII: Molecular forms in commercial factor VIII concentrate, cryoprecipitate, and plasma
7. Purified human factor VIII procoagulant protein: Comparative hemostatic response after infusions into hemophilic and von Willebrand disease dogs
8. Biochemical, immunological, and in vivo functional characterization of B-domain-deleted factor VIII
9. Role of the B domain for factor VIII and factor V expression and function
10. Novel forms of B-domain-deleted recombinant factor VIII molecules. Construction and biochemical characterization
11. Manufacturing and characterization of a new B-domain-deleted recombinant factor VIII, r-VIII SQ
12. Carbohydrate characterization of the B-domain deleted recombinant factor VIII, r-VIII SQ
13. Structural and functional characteristics of a B-domain deleted recombinant factor VIII molecule, r-VIII SQ
14. Stabilization of factor VIII in plasma by the von Willebrand factor. Studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand's disease
15. 1684 of factor VIII light chain induces antibodies which inhibit binding of factor VIII to von Willebrand factor
16. Inhibition of human coagulant factor VIII by monoclonal antibodies. Mapping of functional epitopes with recombinant factor VIII fragments
17. A monoclonal antibody to factor VIII inhibits von Willebrand factor binding and thrombin cleavage
18. Influence of phospholipids on the assessment of factor VIII activity