Development of a cytokine analog with enhanced stability using computational ultrahigh throughput screening

Protein Science

Volumn 11, Issue 5, 2002, Pages 1218-1226

  Luo, Peizhi ^a   Hayes, Robert J ^a   Chan, Cheryl ^a   Stark, Diane M ^a   Hwang, Marian Y ^a   Jacinto, Jonathan M ^a   Juvvadi, Padmaja ^a   Chung, Helen S ^a   Kundu, Anirban ^a   Ary, Marie L ^a   Dahiyat, Bassil I ^a  

^a Xencor Inc   (United States)

Author keywords

Computational screen; Cytokines; Granulocyte colony stimulating factor; Protein design; Stability

Indexed keywords

CYCLOPHOSPHAMIDE; CYTOKINE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG HALF LIFE; DRUG STABILITY; DRUG STORAGE; DRUG STRUCTURE; ENZYME ACTIVE SITE; MONKEY; MOUSE; NEUTROPENIA; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN FOLDING; SHELF LIFE; THERMOSTABILITY;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; GRANULOCYTE COLONY-STIMULATING FACTOR; HEAT; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN ENGINEERING;

ANIMALIA; BOVINAE;

EID: 0036224890     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.4580102     Document Type: Article

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