Purification and kinetic characterization of recombinant human mitogen-activated protein kinase kinase kinase COT and the complexes with its cellular partner NF-κB1 p105

Archives of Biochemistry and Biophysics

Volumn 441, Issue 1, 2005, Pages 64-74

  Jia, Yong ^a   Quinn, Christopher M ^a   Bump, Nancy J ^a,b   Clark, Kevin M ^a   Clabbers, Anca ^a   Hardman, Jennifer ^a   Gagnon, Andrew ^a   Kamens, Joanne ^a   Tomlinson, Medha J ^a   Wishart, Neil ^a   Allen, Hamish ^a  

^a ABBOTT LABORATORIES   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

COT; kcat; Km; Kinetic; MAP kinase; MAP3 kinase; Mechanism; Metal cofactor; NF B1 p105; Regulation; Tpl 2

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE MAGNESIUM; CELL PROTEIN; MAGNESIUM ION; MANGANESE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE COT; NF KAPPA B INDUCING KINASE P105; PROTEIN KINASE; PROTEIN P105; PROTEIN SUBUNIT; RECOMBINANT ENZYME; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CANCER OSAKA THYROID 30-397 PROTO ONCOGENE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVITY; COMPLEX FORMATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME PURIFICATION; HUMAN; MACROPHAGE; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN STABILITY; PROTO ONCOGENE; REGULATORY MECHANISM; SOLUBILITY;

BINDING SITES; ENZYME ACTIVATION; ENZYME STABILITY; HUMANS; JURKAT CELLS; KINETICS; MAP KINASE KINASE KINASES; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN PRECURSORS; PROTO-ONCOGENE PROTEINS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 23944499553     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.abb.2005.06.020     Document Type: Article

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