Phosphorylation at Thr-290 regulates Tpl2 binding to NF-κB1/p105 and Tpl2 activation and degradation by lipopolysaccharide

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 7, 2005, Pages 2350-2355

  Cho, Jeonghee ^a   Tsichlis, Philip N ^a  

^a TUFTS MEDICAL CENTER   (United States)

Author keywords

Endotoxin shock; Extracellular signal regulated kinase; Inflammation; Mitogen activated protein kinase; Tpl2 Cot

Indexed keywords

DEATH RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; NUCLEAR FACTOR KAPPA B1; PROTEASOME; PROTEIN P105; PROTEIN P52; PROTEIN P58; PROTEIN SERINE THREONINE KINASE; PROTEIN TPL2; THREONINE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL TYPE; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNITY; INFLAMMATION; MACROPHAGE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STABILITY; PROTO ONCOGENE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STIMULATION; TRANSLATION INITIATION;

ANIMALS; BINDING SITES; CELL LINE; LIPOPOLYSACCHARIDES; MACROPHAGES; MAP KINASE KINASE KINASES; MICE; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; MUTAGENESIS, SITE-DIRECTED; NF-KAPPA B P50 SUBUNIT; PHOSPHORYLATION; PROTEASE INHIBITORS; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS; RECOMBINANT PROTEINS; RNA, MESSENGER; THREONINE; TRANSCRIPTION FACTORS;

EID: 14044270847     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0409856102     Document Type: Article

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