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Volumn 20, Issue 7, 2000, Pages 2334-2342

Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; STRESS ACTIVATED PROTEIN KINASE;

EID: 0034061264     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.7.2334-2342.2000     Document Type: Article
Times cited : (69)

References (61)
  • 1
    • 0029992810 scopus 로고    scopus 로고
    • Signaling in the yeast pheromone response pathway: Specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7
    • Bardwell, L., J. G. Cook, E. C. Chang, B. R. Cairns, and J. Thorner. 1996. Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7. Mol. Cell. Biol. 16:3637-3650.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3637-3650
    • Bardwell, L.1    Cook, J.G.2    Chang, E.C.3    Cairns, B.R.4    Thorner, J.5
  • 2
    • 0029913457 scopus 로고    scopus 로고
    • Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase
    • Blank, J. L., P. Gerwins, E. M. Elliott, S. Sather, and G. L. Johnson. 1996. Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase. J. Biol. Chem. 271:5361-5368.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5361-5368
    • Blank, J.L.1    Gerwins, P.2    Elliott, E.M.3    Sather, S.4    Johnson, G.L.5
  • 4
    • 0027983908 scopus 로고
    • Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. Cerevisiae
    • Choi, K. Y., B. Satterberg, D. M. Lyons, and E. A. Elion. 1994. Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell 78:499-512.
    • (1994) Cell , vol.78 , pp. 499-512
    • Choi, K.Y.1    Satterberg, B.2    Lyons, D.M.3    Elion, E.A.4
  • 6
    • 0029043582 scopus 로고
    • How MAP kinases are regulated
    • Cobb, M. H., and E. J. Goldsmith. 1995. How MAP kinases are regulated. J. Biol. Chem. 270:14843-14846.
    • (1995) J. Biol. Chem. , vol.270 , pp. 14843-14846
    • Cobb, M.H.1    Goldsmith, E.J.2
  • 7
    • 0032127814 scopus 로고    scopus 로고
    • Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1
    • Cuenda, A., and D. S. Dorow. 1998. Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1. Biochem. J. 333:11-15.
    • (1998) Biochem. J. , vol.333 , pp. 11-15
    • Cuenda, A.1    Dorow, D.S.2
  • 8
    • 0032603404 scopus 로고    scopus 로고
    • Signal transduction by the c-Jun N-terminal kinase
    • Davis, R. J. 1999. Signal transduction by the c-Jun N-terminal kinase. Biochem. Soc. Symp. 64:1-12.
    • (1999) Biochem. Soc. Symp. , vol.64 , pp. 1-12
    • Davis, R.J.1
  • 9
    • 0030952084 scopus 로고    scopus 로고
    • Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/ p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo
    • Deacon, K., and J. L. Blank. 1997. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/ p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. J. Biol. Chem. 272:14489-14496.
    • (1997) J. Biol. Chem. , vol.272 , pp. 14489-14496
    • Deacon, K.1    Blank, J.L.2
  • 11
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • Derijard, B., M. Hibi, I. H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R. J. Davis. 1994. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037.
    • (1994) Cell , vol.76 , pp. 1025-1037
    • Derijard, B.1    Hibi, M.2    Wu, I.H.3    Barrett, T.4    Su, B.5    Deng, T.6    Karin, M.7    Davis, R.J.8
  • 12
    • 0028935974 scopus 로고
    • Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms
    • Erratum, 269:17, 1995
    • Derijard, B., J. Raingeaud, T. Barrett, I. H. Wu, J. Han, R. J. Ulevitch, and R. J. Davis. 1995. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267:682-685. (Erratum, 269:17, 1995.)
    • (1995) Science , vol.267 , pp. 682-685
    • Derijard, B.1    Raingeaud, J.2    Barrett, T.3    Wu, I.H.4    Han, J.5    Ulevitch, R.J.6    Davis, R.J.7
  • 13
    • 0032508546 scopus 로고    scopus 로고
    • Routing MAP kinase cascades
    • Elion, E. A. 1998. Routing MAP kinase cascades. Science 281:1625-1626.
    • (1998) Science , vol.281 , pp. 1625-1626
    • Elion, E.A.1
  • 14
    • 0031044561 scopus 로고    scopus 로고
    • MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: Upstream regulators of the c-Jun amino-terminal kinases?
    • Fanger, G. R., P. Gerwins, C. Widmann, M. B. Jarpe, and G. L. Johnson. 1997. MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases? Curr. Opin. Genet. Dev. 7:67-74.
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 67-74
    • Fanger, G.R.1    Gerwins, P.2    Widmann, C.3    Jarpe, M.B.4    Johnson, G.L.5
  • 15
    • 0032502772 scopus 로고    scopus 로고
    • Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli
    • Foltz, I. N., R. E. Gerl, J. S. Wieler, M. Luckach, R. A. Salmon, and J. W. Schrader. 1998. Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli. J. Biol. Chem. 273:9344-9351.
    • (1998) J. Biol. Chem. , vol.273 , pp. 9344-9351
    • Foltz, I.N.1    Gerl, R.E.2    Wieler, J.S.3    Luckach, M.4    Salmon, R.A.5    Schrader, J.W.6
  • 16
    • 0032910168 scopus 로고    scopus 로고
    • Organization and regulation of mitogen-activated protein kinase signaling pathways
    • Garrington, T. P., and G. L. Johnson. 1999. Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr. Opin. Cell Biol. 11:211-218.
    • (1999) Curr. Opin. Cell Biol. , vol.11 , pp. 211-218
    • Garrington, T.P.1    Johnson, G.L.2
  • 17
    • 0030934694 scopus 로고    scopus 로고
    • Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway
    • Gerwins, P., J. L. Blank, and G. L. Johnson. 1997. Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. J. Biol. Chem. 272:8288-8295.
    • (1997) J. Biol. Chem. , vol.272 , pp. 8288-8295
    • Gerwins, P.1    Blank, J.L.2    Johnson, G.L.3
  • 18
    • 0027936755 scopus 로고
    • A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    • Han, J., J. D. Lee, L. Bibbs, and R. J. Ulevitch. 1994. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265:808-811.
    • (1994) Science , vol.265 , pp. 808-811
    • Han, J.1    Lee, J.D.2    Bibbs, L.3    Ulevitch, R.J.4
  • 19
    • 0028985079 scopus 로고
    • MAP kinase pathways in yeast: For mating and more
    • Herskowitz, I. 1995. MAP kinase pathways in yeast: for mating and more. Cell 80:187-197.
    • (1995) Cell , vol.80 , pp. 187-197
    • Herskowitz, I.1
  • 20
    • 0028897113 scopus 로고
    • Transcriptional regulation by extracellular signals: Mechanisms and specificity
    • Hill, C. S., and R. Treisman. 1995. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 80:199-211.
    • (1995) Cell , vol.80 , pp. 199-211
    • Hill, C.S.1    Treisman, R.2
  • 21
    • 0032571362 scopus 로고    scopus 로고
    • Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/ mixed lineage kinase 2
    • Hirai, S., K. Noda, T. Moriguchi, E. Nishida, A. Yamashita, T. Deyama, K. Fukuyama, and S. Ohno. 1998. Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/ mixed lineage kinase 2. J. Biol. Chem. 273:7406-7412.
    • (1998) J. Biol. Chem. , vol.273 , pp. 7406-7412
    • Hirai, S.1    Noda, K.2    Moriguchi, T.3    Nishida, E.4    Yamashita, A.5    Deyama, T.6    Fukuyama, K.7    Ohno, S.8
  • 22
    • 0030825190 scopus 로고    scopus 로고
    • MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous
    • Holland, P. M., M. Suzanne, J. S. Campbell, S. Noselli, and J. A. Cooper. 1997. MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous. J. Biol. Chem. 272:24994-24998.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24994-24998
    • Holland, P.M.1    Suzanne, M.2    Campbell, J.S.3    Noselli, S.4    Cooper, J.A.5
  • 24
    • 0032054723 scopus 로고    scopus 로고
    • Signal transduction by the c-Jun N-terminal kinase (JNK) - From inflammation to development
    • Ip, Y. T., and R. J. Davis. 1998. Signal transduction by the c-Jun N-terminal kinase (JNK) - from inflammation to development. Curr. Opin. Cell Biol. 10:205-219.
    • (1998) Curr. Opin. Cell Biol. , vol.10 , pp. 205-219
    • Ip, Y.T.1    Davis, R.J.2
  • 25
    • 0031825424 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase cascades as regulators of stress responses
    • Karin, M. 1998. Mitogen-activated protein kinase cascades as regulators of stress responses. Ann. N. Y. Acad. Sci. 851:139-146.
    • (1998) Ann. N. Y. Acad. Sci. , vol.851 , pp. 139-146
    • Karin, M.1
  • 26
    • 0029328342 scopus 로고
    • Transcriptional control by protein phosphorylation: Signal transmission from the cell surface to the nucleus
    • Karin, M., and T. Hunter. 1995. Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Curr. Biol. 5:747-757.
    • (1995) Curr. Biol. , vol.5 , pp. 747-757
    • Karin, M.1    Hunter, T.2
  • 27
    • 0027215820 scopus 로고
    • A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
    • Lange-Carter, C. A., C. M. Pleiman, A. M. Gardner, K. J. Blunter, and G. L. Johnson. 1993. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260:315-319.
    • (1993) Science , vol.260 , pp. 315-319
    • Lange-Carter, C.A.1    Pleiman, C.M.2    Gardner, A.M.3    Blunter, K.J.4    Johnson, G.L.5
  • 28
    • 0032585615 scopus 로고    scopus 로고
    • Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro
    • Lawler, S., Y. Fleming, M. Goedert, and P. Cohen. 1998. Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro. Curr. Biol. 8:1387-1390.
    • (1998) Curr. Biol. , vol.8 , pp. 1387-1390
    • Lawler, S.1    Fleming, Y.2    Goedert, M.3    Cohen, P.4
  • 29
    • 0030581626 scopus 로고    scopus 로고
    • The primary structure of p38 gamma: A new member of p38 group of MAP kinases
    • Li, Z., Y. Jiang, R. J. Ulevitch, and J. Han. 1996. The primary structure of p38 gamma: a new member of p38 group of MAP kinases. Biochem. Biophys. Res. Commun. 228:334-340.
    • (1996) Biochem. Biophys. Res. Commun. , vol.228 , pp. 334-340
    • Li, Z.1    Jiang, Y.2    Ulevitch, R.J.3    Han, J.4
  • 31
    • 0030770419 scopus 로고    scopus 로고
    • Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38
    • Lu, X., S. Nemoto, and A. Lin. 1997. Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. J. Biol. Chem. 272:24751-24754.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24751-24754
    • Lu, X.1    Nemoto, S.2    Lin, A.3
  • 32
    • 0027991228 scopus 로고
    • Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module
    • Marcus, S., A. Polverino, M. Barr, and M. Wigler. 1994. Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module. Proc. Natl. Acad. Sci. USA 91:7762-7766.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7762-7766
    • Marcus, S.1    Polverino, A.2    Barr, M.3    Wigler, M.4
  • 33
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall, C. J. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185.
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 34
    • 0033538003 scopus 로고    scopus 로고
    • The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate
    • Merrill, S. E., M. Mata, D. Nihalani, C. Zhu, X. Hu, and L. B. Holzman. 1999. The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate. J. Biol. Chem. 274:10195-10202.
    • (1999) J. Biol. Chem. , vol.274 , pp. 10195-10202
    • Merrill, S.E.1    Mata, M.2    Nihalani, D.3    Zhu, C.4    Hu, X.5    Holzman, L.B.6
  • 35
    • 0030703604 scopus 로고    scopus 로고
    • Regulation and function of the JNK subgroup of MAP kinases
    • Minden, A., and M. Karin. 1997. Regulation and function of the JNK subgroup of MAP kinases. Biochim. Biophys. Acta 1333:F85-F104.
    • (1997) Biochim. Biophys. Acta , vol.1333
    • Minden, A.1    Karin, M.2
  • 37
    • 0030702895 scopus 로고    scopus 로고
    • A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses
    • Moriguchi, T., F. Toyoshima, N. Masuyama, H. Hanafusa, Y. Gotoh, and E. Nishida. 1997. A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses. EMBO J. 16:7045-7053.
    • (1997) EMBO J. , vol.16 , pp. 7045-7053
    • Moriguchi, T.1    Toyoshima, F.2    Masuyama, N.3    Hanafusa, H.4    Gotoh, Y.5    Nishida, E.6
  • 38
    • 0030815562 scopus 로고    scopus 로고
    • Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: Scaffold role of Pbs2p MAPKK
    • Posas, F., and H. Saito. 1997. Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK. Science 276:1702-1705.
    • (1997) Science , vol.276 , pp. 1702-1705
    • Posas, F.1    Saito, H.2
  • 39
    • 0028046412 scopus 로고
    • Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade
    • Printen, J. A., and G. F. Sprague, Jr. 1994. Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics 138:609-619.
    • (1994) Genetics , vol.138 , pp. 609-619
    • Printen, J.A.1    Sprague G.F., Jr.2
  • 40
    • 0028558986 scopus 로고
    • Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
    • Sanchez, I., R. T. Hughes, B. J. Mayer, K. Yee, J. R. Woodgett, J. Avruch, J. M. Kyriakis, and L. I. Zon. 1994. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 372: 794-798.
    • (1994) Nature , vol.372 , pp. 794-798
    • Sanchez, I.1    Hughes, R.T.2    Mayer, B.J.3    Yee, K.4    Woodgett, J.R.5    Avruch, J.6    Kyriakis, J.M.7    Zon, L.I.8
  • 41
    • 0032508538 scopus 로고    scopus 로고
    • MP1: A MEK binding partner that enhances enzymatic activation of the MAP kinase cascade
    • Schaeffer, H. J., A. D. Catling, S. T. Eblen, L. S. Collier, A. Krauss, and M. J. Weber. 1998. MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science 281:1668-1671.
    • (1998) Science , vol.281 , pp. 1668-1671
    • Schaeffer, H.J.1    Catling, A.D.2    Eblen, S.T.3    Collier, L.S.4    Krauss, A.5    Weber, M.J.6
  • 43
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • Seger, R., and E. G. Krebs. 1995. The MAPK signaling cascade. FASEB J. 9:726-735.
    • (1995) FASEB J , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 45
    • 0028291525 scopus 로고
    • JNK is involved in signal integration during costimulation of T lymphocytes
    • Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77:727-736.
    • (1994) Cell , vol.77 , pp. 727-736
    • Su, B.1    Jacinto, E.2    Hibi, M.3    Kallunki, T.4    Karin, M.5    Ben-Neriah, Y.6
  • 46
    • 0030175485 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase cascades and regulation of gene expression
    • Su, B., and M. Karin. 1996. Mitogen-activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 8:402-411.
    • (1996) Curr. Opin. Immunol. , vol.8 , pp. 402-411
    • Su, B.1    Karin, M.2
  • 47
    • 0029913510 scopus 로고    scopus 로고
    • Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family
    • Teramoto, H., O. A. Coso, H. Miyata, T. Igishi, T. Miki, and J. S. Gutkind. 1996. Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family. J. Biol. Chem. 271:27225-27228.
    • (1996) J. Biol. Chem. , vol.271 , pp. 27225-27228
    • Teramoto, H.1    Coso, O.A.2    Miyata, H.3    Igishi, T.4    Miki, T.5    Gutkind, J.S.6
  • 49
    • 0030786344 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase
    • Tournier, C., A. J. Whitmarsh, J. Cavanagh, T. Barrett, and R. J. Davis. 1997. Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc. Natl. Acad. Sci. USA 94:7337-7342.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 7337-7342
    • Tournier, C.1    Whitmarsh, A.J.2    Cavanagh, J.3    Barrett, T.4    Davis, R.J.5
  • 51
    • 0029954102 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase
    • Wang, X. S., K. Diener, D. Jannuzzi, D. Trollinger, T. H. Tan, H. Lichenstein, M. Zukowski, and Z. Yao. 1996. Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase. J. Biol. Chem. 271:31607-31611.
    • (1996) J. Biol. Chem. , vol.271 , pp. 31607-31611
    • Wang, X.S.1    Diener, K.2    Jannuzzi, D.3    Trollinger, D.4    Tan, T.H.5    Lichenstein, H.6    Zukowski, M.7    Yao, Z.8
  • 52
    • 0032508714 scopus 로고    scopus 로고
    • A mammalian scaffold complex that selectively mediates MAP kinase activation
    • Whitmarsh, A. J., J. Cavanagh, C. Tournier, J. Yasuda, and R. J. Davis. 1998. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 281:1671-1674.
    • (1998) Science , vol.281 , pp. 1671-1674
    • Whitmarsh, A.J.1    Cavanagh, J.2    Tournier, C.3    Yasuda, J.4    Davis, R.J.5
  • 54
    • 0030689618 scopus 로고    scopus 로고
    • Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase
    • Wu, Z., J. Wu, E. Jacinto, and M. Karin. 1997. Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase. Mol. Cell. Biol. 17:7407-7416.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 7407-7416
    • Wu, Z.1    Wu, J.2    Jacinto, E.3    Karin, M.4
  • 55
    • 0032213146 scopus 로고    scopus 로고
    • JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension
    • Xia, Y., Z. Wu, B. Su, B. Murray, and M. Karin. 1998. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. Genes Dev. 12:3369-3381.
    • (1998) Genes Dev. , vol.12 , pp. 3369-3381
    • Xia, Y.1    Wu, Z.2    Su, B.3    Murray, B.4    Karin, M.5
  • 56
    • 0031450154 scopus 로고    scopus 로고
    • MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases
    • Xu, S., and M. H. Cobb. 1997. MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. J. Biol. Chem. 272:32056-32060.
    • (1997) J. Biol. Chem. , vol.272 , pp. 32056-32060
    • Xu, S.1    Cobb, M.H.2
  • 57
    • 0029942952 scopus 로고    scopus 로고
    • Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain
    • Xu, S., D. J. Robbins, L. B. Christerson, J. M. English, C. A. Vanderbilt, and M. H. Cobb. 1996. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proc. Natl. Acad. Sci. USA 93:5291-5295.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 5291-5295
    • Xu, S.1    Robbins, D.J.2    Christerson, L.B.3    English, J.M.4    Vanderbilt, C.A.5    Cobb, M.H.6
  • 59
    • 0032574950 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a human protein kinase that specifically activates c-Jun N-terminal kinase
    • Yang, J., L. New, Y. Jiang, J. Han, and B. Su. 1998. Molecular cloning and characterization of a human protein kinase that specifically activates c-Jun N-terminal kinase. Gene 212:95-102.
    • (1998) Gene , vol.212 , pp. 95-102
    • Yang, J.1    New, L.2    Jiang, Y.3    Han, J.4    Su, B.5
  • 61
    • 0029055761 scopus 로고
    • Components of a new human protein kinase signal transduction pathway
    • Zhou, G., Z. Q. Bao, and J. E. Dixon. 1995. Components of a new human protein kinase signal transduction pathway. J. Biol. Chem. 270:12665-12669.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12665-12669
    • Zhou, G.1    Bao, Z.Q.2    Dixon, J.E.3


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