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1
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0033772264
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OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28
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Alexander C., Votruba M., Pesch U.E., Thiselton D.L., Mayer S., Moore A., Rodriguez M., Kellner U., Leo-Kottler B., Auburger G.et al. OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28. Nat. Genet. 26:2000;211-215.
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2
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Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy
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Delettre C., Lenaers G., Griffoin J.M., Gigarel N., Lorenzo C., Belenguer P., Pelloquin L., Grosgeorge J., Turc-Carel C., Perret E.et al. Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy. Nat. Genet. 26:2000;207-210.
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The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton
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Hermann G.J., King E.J., Shaw J.M. The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton. J. Cell Biol. 137:1997;141-153.
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Arp2/3 complex and actin dynamics are required for actin-based mitochondrial motility in yeast
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Boldogh I.R., Yang H.C., Nowakowski W.D., Karmon S.L., Hays L.G., Yates J.R. III, Pon L.A. Arp2/3 complex and actin dynamics are required for actin-based mitochondrial motility in yeast. Proc. Natl. Acad Sci. USA. 98:2001;3162-3167.
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Yaffe M.P., Harata D., Verde F., Eddison M., Toda T., Nurse P. Microtubules mediate mitochondrial distribution in fission yeast. Proc. Natl. Acad Sci. USA. 93:1996;11664-11668.
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MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria
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Burgess S.M., Delannoy M., Jensen R.E. MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria. J. Cell Biol. 126:1994;1375-1391.
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Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane
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Sogo L.F., Yaffe M.P. Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane. J. Cell Biol. 126:1994;1361-1373.
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Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast
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Berger K.H., Sogo L.F., Yaffe M.P. Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast. J. Cell Biol. 136:1997;545-553.
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Interaction between mitochondria and the actin cytoskeleton in budding yeast requires two integral mitochondrial outer membrane proteins, Mmm1p and Mdm10p
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Boldogh I., Vojtov N., Karmon S., Pon L.A. Interaction between mitochondria and the actin cytoskeleton in budding yeast requires two integral mitochondrial outer membrane proteins, Mmm1p and Mdm10p. J. Cell Biol. 141:1998;1371-1381.
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Boldogh, I.1
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Starr D.A., Han M. Role of ANC-1 in tethering nuclei to the actin cytoskeleton. Science. 298:2002;406-409.
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Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA
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Nunnari J., Marshall W.F., Straight A., Murray A., Sedat J.W., Walter P. Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA. Mol. Biol. Cell. 8:1997;1233-1242.
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Nunnari, J.1
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Gag3p, an outer membrane protein required for fission of mitochondrial tubules
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Fekkes P., Shepard K.A., Yaffe M.P. Gag3p, an outer membrane protein required for fission of mitochondrial tubules. J. Cell Biol. 151:2000;333-340.
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Fekkes, P.1
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Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p
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Mozdy A.D., McCaffery J.M., Shaw J.M. Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J. Cell Biol. 151:2000;367-380.
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Mozdy, A.D.1
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Shaw, J.M.3
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15
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0034676101
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Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division
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Tieu Q., Nunnari J. Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division. J. Cell Biol. 151:2000;353-366.
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Tieu, Q.1
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Division of mitochondria requires a novel DMN1-interacting protein, Net2p
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Cerveny K.L., McCaffery J.M., Jensen R.E. Division of mitochondria requires a novel DMN1-interacting protein, Net2p. Mol. Biol. Cell. 12:2001;309-321.
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Cerveny, K.L.1
McCaffery, J.M.2
Jensen, R.E.3
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17
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0036322806
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The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission
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Detailed biochemical, genetic and cytological analysis reveals that Mdv1p interacts with both Fis1p and Dnm1p, leading to model in which Mdv1p acts as a molecular adaptor during mitochondrial fission. In addition, these authors report an allele of Fis1p that separates its two functions. Fis1-L80P successfully localizes Dnm1p to punctate structures on the mitochondria but blocks fission, resulting in a net phenotype
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Tieu Q., Okreglak V., Naylor K., Nunnari J. The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission. J. Cell Biol. 158:2002;445-452 Detailed biochemical, genetic and cytological analysis reveals that Mdv1p interacts with both Fis1p and Dnm1p, leading to model in which Mdv1p acts as a molecular adaptor during mitochondrial fission. In addition, these authors report an allele of Fis1p that separates its two functions. Fis1-L80P successfully localizes Dnm1p to punctate structures on the mitochondria but blocks fission, resulting in a net phenotype.
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Tieu, Q.1
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Nunnari, J.4
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18
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0036198860
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Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae
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This is an analysis of all available yeast deletion strains for defects in mitochondrial morphology and respiration
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Dimmer K.S., Fritz S., Fuchs F., Messerschmitt M., Weinbach N., Neupert W., Westermann B. Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol. Biol. Cell. 13:2002;847-853 This is an analysis of all available yeast deletion strains for defects in mitochondrial morphology and respiration.
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Dimmer, K.S.1
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Neupert, W.6
Westermann, B.7
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19
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0037450656
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The inner membrane protein Mdm33 controls mitochondrial morphology in yeast
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MDM33 encodes an inner membrane protein whose deletion results in ring-like interconnected mitochondria. This gene is required for the formation of nets in strains deleted for components of fission machinery and its overexpression leads to aberrant inner membrane structures. These findings lead to the proposal that Mdm33p in involved in fission of the inner mitochondrial membrane
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Messerschmitt M., Jakobs S., Vogel S., Fritz S., Dimmer K.S., Neupert W., Westermann B. The inner membrane protein Mdm33 controls mitochondrial morphology in yeast. J. Cell Biol. 160:2003;553-564 MDM33 encodes an inner membrane protein whose deletion results in ring-like interconnected mitochondria. This gene is required for the formation of nets in strains deleted for components of fission machinery and its overexpression leads to aberrant inner membrane structures. These findings lead to the proposal that Mdm33p in involved in fission of the inner mitochondrial membrane.
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Messerschmitt, M.1
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20
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Hales K.G., Fuller M.T. Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase. Cell. 90:1997;121-129.
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Hales, K.G.1
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21
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Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p
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Hermann G.J., Thatcher J.W., Mills J.P., Hales K.G., Fuller M.T., Nunnari J., Shaw J.M. Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J. Cell Biol. 143:1998;359-373.
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Hermann, G.J.1
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Control of mitochondrial morphology by a human mitofusin
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Santel A., Fuller M.T. Control of mitochondrial morphology by a human mitofusin. J. Cell Sci. 114:2001;867-874.
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23
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Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion
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This paper describes domain and functional analysis of yeast Fzo1
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Fritz S., Rapaport D., Klanner E., Neupert W., Westermann B. Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion. J. Cell Biol. 152:2001;683-692 This paper describes domain and functional analysis of yeast Fzo1.
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Fritz, S.1
Rapaport, D.2
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Westermann, B.5
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24
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0037455575
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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
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The authors demonstrate that embryonic development requires both Mfn1 and Mfn2 and that both homotypic and heterotypic Mfn complexes are formed
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Chen H., Detmer S.A., Ewald A.J., Griffin E.E., Fraser S.E., Chan D.C. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J. Cell Biol. 160:2003;189-200 The authors demonstrate that embryonic development requires both Mfn1 and Mfn2 and that both homotypic and heterotypic Mfn complexes are formed.
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Chen, H.1
Detmer, S.A.2
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Fraser, S.E.5
Chan, D.C.6
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25
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0037089084
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Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo
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This work demonstrates that the two mouse mitofusins are ubiquitiously expressed and interact via their coiled-coil domains
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Rojo M., Legros F., Chateau D., Lombes A. Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. J. Cell Sci. 115:2002;1663-1674 This work demonstrates that the two mouse mitofusins are ubiquitiously expressed and interact via their coiled-coil domains.
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Rojo, M.1
Legros, F.2
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Lombes, A.4
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26
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0035911963
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UGO1 encodes an outer membrane protein required for mitochondrial fusion
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The outer mitochondrial membrane fusion component Ugo1p is characterized
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Sesaki H., Jensen R.E. UGO1 encodes an outer membrane protein required for mitochondrial fusion. J. Cell Biol. 152:2001;1123-1134 The outer mitochondrial membrane fusion component Ugo1p is characterized.
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Sesaki, H.1
Jensen, R.E.2
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27
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0033593816
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The yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance
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Shepard K.A., Yaffe M.P. The yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance. J. Cell Biol. 144:1999;711-720.
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Shepard, K.A.1
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0034676095
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The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria
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Wong E.D., Wagner J.A., Gorsich S.W., McCaffery J.M., Shaw J.M., Nunnari J. The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. J. Cell Biol. 151:2000;341-352.
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Wong, E.D.1
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Nunnari, J.6
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29
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0037415638
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The intramitochondrial dynamin-related GTPase, Mgm1p is a component of a protein complex that mediate mitochondrial fusion
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Fusion components Ugo1 and Fzo1 interact and the inner-mitochondrial-membrane-associated protein Mgm1 interacts with both Fzo1 and Ugo1. These findings implicate a direct role for Mgm1p in mitochondrial fusion
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Wong E., Wagner J.A., Scott S.V., Okreglak V., Holewinske T.J., Cassidy-Stone A. The intramitochondrial dynamin-related GTPase, Mgm1p is a component of a protein complex that mediate mitochondrial fusion. J. Cell Biol. 160:2003;303-311 Fusion components Ugo1 and Fzo1 interact and the inner-mitochondrial-membrane-associated protein Mgm1 interacts with both Fzo1 and Ugo1. These findings implicate a direct role for Mgm1p in mitochondrial fusion.
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Wong, E.1
Wagner, J.A.2
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Holewinske, T.J.5
Cassidy-Stone, A.6
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30
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0037424239
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Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis
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The authors present an analysis of small interfering RNA downregulation of OPA1 in HeLa cells
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Olichon A., Baricault L., Gas N., Guillou E., Valette A., Belenguer P., Lenaers G. Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J. Biol. Chem. 278:2003;7743-7746 The authors present an analysis of small interfering RNA downregulation of OPA1 in HeLa cells.
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Olichon, A.1
Baricault, L.2
Gas, N.3
Guillou, E.4
Valette, A.5
Belenguer, P.6
Lenaers, G.7
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31
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0033490111
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Fission yeast Msp1 is a mitochondrial dynamin-related protein
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Pelloquin L., Belenguer P., Menon Y., Gas N., Ducommun B. Fission yeast Msp1 is a mitochondrial dynamin-related protein. J. Cell Sci. 112:1999;4151-4161.
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Pelloquin, L.1
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Ducommun, B.5
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32
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0037125183
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The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space
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Localization of OPA1 to the intermembrane space side of the inner mitochondrial membrane is described herein. This work helps resolve conflicting localization reports regarding this protein and its homologues.
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Olichon A., Emorine L.J., Descoins E., Pelloquin L., Brichese L., Gas N., Guillou E., Delettre C., Valette A., Hamel C.P.et al. The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett. 523:2002;171-176 Localization of OPA1 to the intermembrane space side of the inner mitochondrial membrane is described herein. This work helps resolve conflicting localization reports regarding this protein and its homologues.
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FEBS Lett.
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, pp. 171-176
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Olichon, A.1
Emorine, L.J.2
Descoins, E.3
Pelloquin, L.4
Brichese, L.5
Gas, N.6
Guillou, E.7
Delettre, C.8
Valette, A.9
Hamel, C.P.10
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33
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0037427529
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Differential sublocalization of the dynamin-related protein OPA1 isoforms in mitochondria
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The authors characterize the two most abundant splice variants of OPA1
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Satoh M., Hamamoto T., Seo N., Kagawa Y., Endo H. Differential sublocalization of the dynamin-related protein OPA1 isoforms in mitochondria. Biochem. Biophys. Res. Commun. 300:2003;482-493 The authors characterize the two most abundant splice variants of OPA1.
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Biochem. Biophys. Res. Commun.
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Satoh, M.1
Hamamoto, T.2
Seo, N.3
Kagawa, Y.4
Endo, H.5
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35
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0038037754
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Mdm30 is an F-box protein required for maintenance of fusion competent mitochondria in yeast
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published online February 6. DOI 10.1091/mbc.E02-12-0831
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Fritz S, Weinbach N, Westermann B: Mdm30 is an F-box protein required for maintenance of fusion competent mitochondria in yeast. Mol Biol Cell 2003, published online February 6 2003. DOI 10.1091/mbc.E02-12-0831.
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Mol Biol Cell 2003
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Fritz, S.1
Weinbach, N.2
Westermann, B.3
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36
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0033553857
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A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae
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Fisk H.A., Yaffe M.P. A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae. J. Cell Biol. 145:1999;1199-1208.
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Fisk, H.A.1
Yaffe, M.P.2
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37
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0037169358
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Apoptosis: A link between cancer genetics and chemotherapy
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This is a review of the relationship between apoptosis and drug-resistant cancers. In many malignancies, apoptosis is blocked, owing to mutations in genes required for programmed cell death
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Johnstone R.W., Ruefli A.A., Lowe S.W. Apoptosis: a link between cancer genetics and chemotherapy. Cell. 108:2002;153-164 This is a review of the relationship between apoptosis and drug-resistant cancers. In many malignancies, apoptosis is blocked, owing to mutations in genes required for programmed cell death.
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Cell
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, pp. 153-164
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Johnstone, R.W.1
Ruefli, A.A.2
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0032504575
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Mitochondria as regulators of apoptosis: Doubt no more
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Susin S.A., Zamzami N., Kroemer G. Mitochondria as regulators of apoptosis: doubt no more. Biochim. Biophys. Acta. 1366:1998;151-165.
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Susin, S.A.1
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Kroemer, G.3
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39
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0035487808
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The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis
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These authors establish a link between the mitochondrial fragmentation that occurs upon induction of apoptosis and Drp1, which functions in mitochondrial fission events in wild-type cells. They find that inhibition of Drp1 blocks programmed cell death
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Frank S., Gaume B., Bergmann-Leitner E.S., Leitner W.W., Robert E.G., Catez F., Smith C.L., Youle R.J. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev. Cell. 1:2001;515-525 These authors establish a link between the mitochondrial fragmentation that occurs upon induction of apoptosis and Drp1, which functions in mitochondrial fission events in wild-type cells. They find that inhibition of Drp1 blocks programmed cell death.
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Dev. Cell
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, pp. 515-525
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Frank, S.1
Gaume, B.2
Bergmann-Leitner, E.S.3
Leitner, W.W.4
Robert, E.G.5
Catez, F.6
Smith, C.L.7
Youle, R.J.8
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40
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0037164813
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Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis
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