Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate

Nucleic Acids Research

Volumn 32, Issue 2, 2004, Pages 422-431

  McKercher, Ginette ^a   Beaulieu, Pierre L ^a   Lamarre, Daniel ^a   LaPlante, Steven ^a   Lefebvre, Sylvain ^a   Pellerin, Charles ^a   Thauvette, Louise ^a   Kukolj, George ^a  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; DEOXYCYTIDINE KINASE; DNA; IMIDAZOLECARBOXAMIDE; PRIMER DNA; RNA; RNA DIRECTED DNA POLYMERASE INHIBITOR; RNA DIRECTED RNA POLYMERASE; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

3' UNTRANSLATED REGION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA TEMPLATE; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MODIFICATION; ENZYME SUBSTRATE; GENE DELETION; HEPATITIS C VIRUS; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; RNA BINDING; RNA TRANSLATION; VIRUS REPLICATION;

AMIDES; ANIMALS; BENZIMIDAZOLES; CATTLE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HEPACIVIRUS; INHIBITORY CONCENTRATION 50; KINETICS; POLIOVIRUS; RNA; RNA POLYMERASE II; RNA REPLICASE; RNA, VIRAL; SUBSTRATE SPECIFICITY; TEMPLATES, GENETIC; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 1442283032     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkh160     Document Type: Article

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