An inverse substrate orientation for the regioselective acylation of 3′,5′-diaminonucleosides catalyzed by Candida antarctica lipase B?

ChemBioChem

Volumn 6, Issue 8, 2005, Pages 1381-1390

  Lavandera, Iván ^a,b   Fernández, Susana ^a   Magdalena, Julia ^a   Ferrero, Miguel ^a   Kazlauskas, Romas J ^b,c   Gotor, Vicente ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Aminolysis; Biotransformations; Enzyme catalysis; Molecular modeling; Nucleosides

Indexed keywords

3',5' DIAMINO 3',5' DIDEOXYTHYMIDINE; 3',5' DIAMINONUCLEOSIDE; ALCOHOL; AMIDE; AMINE; AMINONUCLEOSIDE; AMMONIA; BUTYRIC ACID; CARBONYL DERIVATIVE; ESTER; FUNGAL ENZYME; HISTIDINE; LIPASE B; METHOXYACETIC ACID; OXIME; PHOSPHONIC ACID DERIVATIVE; PHOSPHONOAMIDATE DERIVATIVE; THYMIDINE; THYMINE; UNCLASSIFIED DRUG; WATER;

ACYLATION; ARTICLE; CATALYSIS; COMPUTER MODEL; ENZYME SUBSTRATE; EXPERIMENTATION; HYDROGEN BOND; HYDROPHOBICITY; PRIORITY JOURNAL; PROTON TRANSPORT; REACTION TIME; STEREOCHEMISTRY;

ACYLATION; BINDING SITES; CANDIDA; CATALYSIS; COMPUTER SIMULATION; KINETICS; LIPASE; MODELS, CHEMICAL; MODELS, MOLECULAR; NUCLEOSIDES; PROTONS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; THYMIDINE;

CANDIDA ANTARCTICA;

EID: 23644447557     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200400422     Document Type: Article

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