Synthesis, protonation behavior, conformational analysis, and regioselective enzymatic acylation of the novel diamino analogue of (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU)

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 10, 2003, Pages 1939-1952

  Lavandera, Irán ^a   Fernández, Susana ^a   Ferrero, Miguel ^a   De Clercq, Erik ^b   Gotor, Vicente ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Aminodeoxynucleosides; Enzymatic acylation; Lipases; Protonation of diamino BVDU

Indexed keywords

3' ACETYLAMINO 5' AMINO 5 (2 BROMOVINYL) 2',3',5' TRIDEOXYURIDINE; 3' AMINO 5 (2 BROMOVINYL) 5' BUTYRYLAMINO 2',3',5' TRIDEOXYURIDINE; 3' AMINO 5 (2 BROMOVINYL) 5' CROTONYLAMINO 2',3',5' TRIDEOXYURIDINE; 3' AMINO 5 (2 BROMOVINYL) 5' FORMYLAMINO 2',3',5' TRIDEOXYURIDINE; 3' AMINO 5' BENZOYLAMINO 5 (2 BROMOVINYL) 2',3',5' TRIDEOXYURIDINE; 3',5' DIAMINO 5 (2 BROMOVINYL) 2',3',5' TRIDEOXYURIDINE; 5 (2 BROMOVINYL) 2' DEOXYURIDINE; 5' ACETYLAMINO 3' AMINO 5 (2 BROMOVINYL) 2',3',5' TRIDEOXYURIDINE; 5' AMINO 5 (2 BROMOVINYL) 3' BUTYRYLAMINO 2',3',5' TRIDEOXYURIDINE; BACTERIAL ENZYME; DEOXYURIDINE DERIVATIVE; DIAMINE DERIVATIVE; FUNGAL ENZYME; LIPASE B; NUCLEOSIDE ANALOG; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ACYLATION; ALKALINITY; ARTICLE; BURKHOLDERIA CEPACIA; CANDIDA ANTARCTICA; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL ANALYSIS; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME IMMOBILIZATION; ENZYME MECHANISM; IONIZATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH MEASUREMENT; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ANALYSIS; TECHNIQUE;

ACYLATION; BROMODEOXYURIDINE; BURKHOLDERIA CEPACIA; CANDIDA; HYDROGEN-ION CONCENTRATION; LIPASE; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PROTONS;

BACTERIA (MICROORGANISMS); BURKHOLDERIA; BURKHOLDERIA CEPACIA; CANDIDA; CANDIDA ANTARCTICA; PSEUDOMONAS;

EID: 0142120623     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120025241     Document Type: Article

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