Catalytic and binding poly-reactivities shared by two unrelated proteins: The potential role of promiscuity in enzyme evolution

Protein Science

Volumn 10, Issue 12, 2001, Pages 2600-2607

  James, Leo C ^a   Tawfik, Dan S ^a,b  

^a Centre for Protein Engineering   (United Kingdom)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Catalytic antibody; Cross reactivity; Directed evolution; Enzyme evolution; Medium effects; Promiscuous promiscuity; Serum albumin; Substrate ambiguity

Indexed keywords

ALBUMIN; CATALYTIC ANTIBODY; ENZYME; FRUCTOSE BISPHOSPHATE ALDOLASE; PROTEIN;

ARTICLE; CATALYSIS; CROSS REACTION; ENZYME ACTIVE SITE; ENZYME MECHANISM; GENETIC SELECTION; HYDROPHOBICITY; MODEL; MOLECULAR EVOLUTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTON TRANSPORT;

BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYMES; EVOLUTION, MOLECULAR; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEINS; SERUM ALBUMIN; TIME FACTORS;

EID: 0035188466     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.ps.14601     Document Type: Article

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