Direct regioselective enzymatic acylation of nucleosides: Building-blocks for the solution phase synthesis of oligonucleotides

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 1455-1457

  Garcia, Javier ^a   Fernández, Susana ^a   Ferrero, Miguel ^a   Sanghvi, Yogesh S ^b   Gotor, Vicente ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; LEVULINIC ACID; MONOMER; NUCLEOSIDE DERIVATIVE; OLIGONUCLEOTIDE; REAGENT;

ACYLATION; CATALYST; CONFERENCE PAPER; NUCLEOTIDE METABOLISM; REACTION ANALYSIS; STEREOCHEMISTRY; TECHNIQUE;

ACYLATION; CANDIDA; LEVULINIC ACIDS; LIPASE; NUCLEOSIDES; OLIGONUCLEOTIDES; OXIMES; STEREOISOMERISM;

EID: 0141707966     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120023009     Document Type: Conference Paper

References (6)

1. For a recent monograph on this topic see: Antisense Drug Technology Principles, Strategies and Applications; Crooke, S.T. Ed.; Marcel Dekker: New York, 2001.
2. Sanghvi, Y.S. Chapter 7. In Comprehensive Natural Products Chemistry; Kool, E.T., Ed.; Elsevier: Amsterdam, 1999; Vol. 7, 285-311.
3. Sanghvi, Y.S. Org. Process R & D 2000, 4, 168-169.
4. García, J.; Fernández, S.; Ferrero, M.; Sanghvi, Y.S.; Gotor, V. J. Org. Chem. 2002, 67, 4513-4519.
5. a) Ferrero, M.; Gotor, V. Chem. Rev. 2000, 100; 4319-4347;
6. Ferrero, M.; Gotor, V. Monatsh. Chem. 2000, 131, 585-616.