Functional characterization and crystal structure of the C215D mutant of protein-tyrosine phosphatase-1B

Journal of Biological Chemistry

Volumn 278, Issue 31, 2003, Pages 29009-29015

  Romsicki, Yolanda ^a   Scapin, Giovanna ^b   Beaulieu Audy, Veronique ^a   Patel, Sangita ^b   Becker, Joseph W ^b   Kennedy, Brian P ^a   Asante Appiah, Ernest ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ENERGY; BIOCHEMISTRY; CATALYST ACTIVITY; CONFORMATIONS; CRYSTAL STRUCTURE; FERMENTATION; HYDROLYSIS; MUTAGENESIS; PH; REACTION KINETICS; SCREENING; SOLVENTS; SUGAR (SUCROSE); VISCOSITY;

ARRHENIUS PLOTS;

ENZYMES;

4 NITROPHENYL PHOSPHATE; APOENZYME; ASPARTIC ACID; MUTANT PROTEIN; NATURAL PRODUCT; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; SOLVENT; SUCROSE; UNCLASSIFIED DRUG;

ACIDITY; AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DRUG SCREENING; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME SUBSTRATE; FERMENTATION; HYDROLYSIS; OXIDATION; PRIORITY JOURNAL; REACTION ANALYSIS; VISCOSITY;

BINDING SITES; CATALYSIS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; NITROPHENOLS; ORGANOPHOSPHORUS COMPOUNDS; PROTEIN CONFORMATION; PROTEIN-TYROSINE-PHOSPHATASE; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; VISCOSITY;

ARRHENIUS;

EID: 0042707760     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303817200     Document Type: Article

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