What is the importance of the immunological synapse?

Trends in Immunology

Volumn 25, Issue 6, 2004, Pages 323-327

  Davis, Daniel M ^a   Dustin, Michael L ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN; PERFORIN; T LYMPHOCYTE RECEPTOR; TUBULIN;

CALCIUM SIGNALING; CELL COMMUNICATION; CELL FUNCTION; CELL INTERACTION; CLUSTER ANALYSIS; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; DOWN REGULATION; GENE CLUSTER; IMMUNE SYSTEM; LEUKOCYTE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR BIOLOGY; NATURAL KILLER CELL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; SYNAPSE; T LYMPHOCYTE;

ANIMALS; ANTIGEN-PRESENTING CELLS; CELL COMMUNICATION; HUMANS; INTERCELLULAR JUNCTIONS; KILLER CELLS, NATURAL; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 2342566929     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2004.03.007     Document Type: Review

References (53)

1. Norcross M.A. A synaptic basis for T-lymphocyte activation. Ann. Immunol. (Paris). 135D:1984;113-134
2. Paul W.E., Seder R.A. Lymphocyte responses and cytokines. Cell. 76:1994;241-251
3. Monks C.R., et al. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature. 395:1998;82-86
4. Dustin M.L., et al. A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. Cell. 94:1998;667-677
5. Grakoui A., et al. The immunological synapse: a molecular machine controlling T cell activation. Science. 285:1999;221-227
6. Davis D.M., et al. The human natural killer cell immune synapse. Proc. Natl. Acad. Sci. U. S. A. 96:1999;15062-15067
7. Batista F.D., et al. B cells acquire antigen from target cells after synapse formation. Nature. 411:2001;489-494
8. Carlin L.M., et al. Intercellular transfer and supramolecular organization of human leukocyte antigen C at inhibitory natural killer cell immune synapses. J. Exp. Med. 194:2001;1507-1517
9. Vyas Y.M., et al. Spatial organization of signal transduction molecules in the NK cell immune synapses during MHC class I-regulated noncytolytic and cytolytic interactions. J. Immunol. 167:2001;4358-4367
10. McCann F.E., et al. The size of the synaptic cleft and distinct distributions of filamentous actin, ezrin, CD43, and CD45 at activating and inhibitory human NK cell immune synapses. J. Immunol. 170:2003;2862-2870
11. Davis D.M. Assembly of the immunological synapse for T cells and NK cells. Trends Immunol. 23:2002;356-363
12. Igakura T., et al. Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton. Science. 299:2003;1713-1716
13. McDonald D., et al. Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science. 300:2003;1295-1297
14. Tskvitaria-Fuller I., et al. Regulation of sustained actin dynamics by the TCR and costimulation as a mechanism of receptor localization. J. Immunol. 171:2003;2287-2295
15. Faure S., et al. ERM proteins regulate cytoskeleton relaxation promoting T cell-APC conjugation. Nat. Immun. 5:2004;272-279
16. Moretta L., et al. Human NK cells and their receptors. Microbes Infect. 4:2002;1539-1544
17. Arase H., Lanier L.L. Virus-driven evolution of natural killer cell receptors. Microbes Infect. 4:2002;1505-1512
18. Yokoyama W.M., Plougastel B.F. Immune functions encoded by the natural killer gene complex. Nat. Rev. Immunol. 3:2003;304-316
19. Orange J.S., et al. The mature activating natural killer cell immunologic synapse is formed in distinct stages. Proc. Natl. Acad. Sci. U. S. A. 100:2003;14151-14156
20. Wulfing C., et al. Stepwise cytoskeletal polarization as a series of checkpoints in innate but not adaptive cytolytic killing. Proc. Natl. Acad. Sci. U. S. A. 100:2003;7767-7772
21. Stebbins C.C., et al. Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity. Mol. Cell. Biol. 23:2003;6291-6299
22. Raulet D.H. Roles of the NKG2D immunoreceptor and its ligands. Nat. Rev. Immunol. 3:2003;781-790
23. Gleimer M., Parham P. Stress management: MHC class I and class I-like molecules as reporters of cellular stress. Immunity. 19:2003;469-477
24. Eleme K., et al. Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D. J. Exp. Med. 199:2004;1005-1010
25. Somersalo K., et al. Cytotoxic T lymphocytes form an antigen-independent ring junction. J. Clin. Invest. 113:2004;49-57
26. Qi S.Y., et al. Synaptic pattern formation during cellular recognition. Proc. Natl. Acad. Sci. U. S. A. 98:2001;6548-6553
27. Burroughs N.J., Wulfing C. Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse. Biophys. J. 83:2002;1784-1796
28. Dustin M.L., et al. Identification of self through two-dimensional chemistry and synapses. Annu. Rev. Cell Dev. Biol. 17:2001;133-157
29. Lee K.H., et al. T cell receptor signaling precedes immunological synapse formation. Science. 295:2002;1539-1542
30. Valitutti S., et al. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J. Exp. Med. 183:1996;1917-1921
31. Faroudi M., et al. Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold. Proc. Natl. Acad. Sci. U. S. A. 100:2003;14145-14150
32. Lee K.H., et al. The immunological synapse balances T cell receptor signaling and degradation. Science. 302:2003;1218-1222
33. Germain R.N. T-cell signaling: the importance of receptor clustering. Curr. Biol. 7:1997;R640-R644
34. Sykulev Y., et al. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. Immunity. 4:1996;565-571
35. Irvine D.J., et al. Direct observation of ligand recognition by T cells. Nature. 419:2002;845-849
36. Huppa J.B., et al. Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat. Immun. 4:2003;749-755
37. Baumgart T., et al. Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension. Nature. 425:2003;821-824
38. Rustom A., et al. Nanotubular highways for intercellular organelle transport. Science. 303:2004;1007-1010
39. Sulston J., Ferry G. The Common Thread. A Story of Science, Politics, Ethics and the Human Genome. 2002;Bantam Press
40. Potter T.A., et al. Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells. Proc. Natl. Acad. Sci. U. S. A. 98:2001;12624-12629
41. Stinchcombe J.C., et al. The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity. 15:2001;751-761
42. Clark R.H., et al. Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse. Nat. Immun. 4:2003;1111-1120
43. Vyas Y.M., et al. Cutting edge: differential segregation of the SRC homology 2-containing protein tyrosine phosphatase-1 within the early NK cell immune synapse distinguishes noncytolytic from cytolytic interactions. J. Immunol. 168:2002;3150-3154
44. Orange J.S., et al. Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses. Proc. Natl. Acad. Sci. U. S. A. 99:2002;11351-11356
45. Favier B., et al. Uncoupling between immunological synapse formation and functional outcome in human gamma delta T lymphocytes. J. Immunol. 171:2003;5027-5033
46. Vyas Y.M., et al. Visualization of signaling pathways and cortical cytoskeleton in cytolytic and noncytolytic natural killer cell immune synapses. Immunol. Rev. 189:2002;161-178
47. Panyi G., et al. Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells. Proc. Natl. Acad. Sci. U. S. A. 101:2004;1285-1290
48. Schaefer B.C., et al. Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation. Proc. Natl. Acad. Sci. U. S. A. 101:2004;1004-1009
49. Freiberg B.A., et al. Staging and resetting T cell activation in SMACs. Nat. Immun. 3:2002;911-917
50. Hudrisier D., Bongrand P. Intercellular transfer of antigen-presenting cell determinants onto T cells: molecular mechanisms and biological significance. FASEB J. 16:2002;477-486
51. Huang J.F., et al. TCR-mediated internalization of peptide-MHC complexes acquired by T cells. Science. 286:1999;952-954
52. Poo W.J., et al. Receptor-directed focusing of lymphokine release by helper T cells. Nature. 332:1988;378-380
53. Kupfer A., Kupfer H. Imaging immune cell interactions and functions: SMACs and the Immunological Synapse. Semin. Immunol. 15:2003;295-300