Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton

Science

Volumn 299, Issue 5613, 2003, Pages 1713-1716

  Igakura, Tadahiko ^a,b   Stinchcombe, Jane C ^c   Goon, Peter K C ^a   Taylor, Graham P ^a   Weber, Jonathan N ^a   Griffiths, Gillian M ^c   Tanaka, Yuetsu ^d   Osame, Mitsuhiro ^b   Bangham, Charles R M ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; PHYSIOLOGY; POLARIZATION;

LYMPHOCYTES;

VIRUSES;

GAG PROTEIN; VIRUS PROTEIN;

DISEASE; GENOME; MICROBIOLOGY;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; CELL CONTACT; CELL JUNCTION; CELL SPREADING; CONFOCAL MICROSCOPY; CYTOSKELETON; GENOME; HUMAN T CELL LEUKEMIA VIRUS 1; LYMPHOCYTE; MICROTUBULE ORGANIZING CENTER; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; T LYMPHOCYTE; TRANSPORT KINETICS; VIRION; VIRUS TRANSMISSION;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL ADHESION MOLECULES; CELL COMMUNICATION; CELL LINE; CELL POLARITY; EXTRACELLULAR SPACE; GENE PRODUCTS, ENV; GENE PRODUCTS, GAG; GENOME, VIRAL; HTLV-I INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INTERCELLULAR JUNCTIONS; MICROSCOPY, CONFOCAL; MICROTUBULE-ORGANIZING CENTER; MICROTUBULES; NUCLEOCAPSID PROTEINS; PEPTIDE NUCLEIC ACIDS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; TALIN; VIRION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN T-LYMPHOTROPIC VIRUS 1; RNA VIRUSES;

EID: 0242515763     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1080115     Document Type: Article

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30. We thank the staff and patients of St. Mary's Hospital for their cooperation, Q. Sattentau and D. M. Davis (Imperial College, UK) for helpful discussions, A. Barnard for help with the MTOC orientation experiments, and N. White (Sir William Dunn School of Pathology, University of Oxford, UK) for help with the use of the confocal microscope facility. This work was supported by The Wellcome Trust (UK).