Assembly of the immunological synapse for T cells and NK cells

Trends in Immunology

Volumn 23, Issue 7, 2002, Pages 356-363

  Davis, Daniel M ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; LIPID; PROTEIN;

CELL ACTIVATION; CELL CONTACT; CELL SURFACE; CYTOSKELETON; FLUORESCENCE; FLUORESCENCE SPECTROSCOPY; HUMAN; IMAGING; IMMUNOSURVEILLANCE; LYMPHOCYTE; NATURAL KILLER CELL; PHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN SECRETION; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION; SYNAPSE; T LYMPHOCYTE;

CELL COMMUNICATION; HUMANS; KILLER CELLS, NATURAL; MEMBRANE PROTEINS; T-LYMPHOCYTES;

EID: 0036644617     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(02)02243-3     Document Type: Review

References (87)

1. Three-dimensional segregation of supramolecular activation clusters in T cells
2. The immunological synapse: A molecular machine controlling T cell activation
3. The human natural killer cell immune synapse
4. The immunological synapse and the actin cytoskeleton: Molecular hardware for T cell signaling
5. Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition
6. Identification of self through two-dimensional chemistry and synapses
7. Information transfer at the immunological synapse
8. Imaging T-cell antigen recognition and comparing immunological and neuronal synapses
9. Molecular recognition of disease at natural killer cell immune synapses
10. The immunological synapse
11. Dynamics of the immunological synapse: Finding, establishing and solidifying a connection
12. Contact-induced redistribution of specific membrane components: Local accumulation and development of adhesion
13. The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose
14. A receptor/cytoskeletal movement triggered by costimulation during T cell activation
15. Visualizing the dynamics of T cell activation: Intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels
16. Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization
17. Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts
18. Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes
19. The glycosynapse
20. Rho GTPases link cytoskeletal rearrangements and activation processes induced via the tetraspanin CD82 in T lymphocytes
21. The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface
22. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells
23. Costimulation and endogenous MHC ligands contribute to T cell recognition
24. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
25. Regulation of Lck activity by CD4 and CD28 in the immunological synapse
26. Intercellular transfer and supramolecular organization of human leukocyte antigen C at inhibitory natural killer cell immune synapses
27. Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling
28. WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation
29. Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes
30. The dendritic cell cytoskeleton is critical for the formation of the immunological synapse
31. TCR dynamics on the surface of living T cells
32. Functional antigen-independent synapses formed between T cells and dendritic cells
33. 2+ responses triggered in T cells by dendritic cells compared with B cells
34. Role of ICAM-3 in the initial interaction of T lymphocytes and APCs
35. The immunological synapse of CTL contains a secretory domain and membrane bridges
36. Dependence of T cell antigen recognition on the dimensions of an accessory receptor-ligand complex
37. Synaptic pattern formation during cellular recognition
38. How and why does the immunological synapse form? Physical chemistry meets cell biology
39. Polar redistribution of the sialoglycoprotein CD43: Implications for T cell function
40. Cutting edge: Differential segregation of the SRC homology 2-containing protein tyrosine phosphatase-1 within the early NK cell immune synapse distinguishes noncytolytic from cytolytic interactions
41. Spatial organization of signal transduction molecules in the NK cell immune synapses during MHC class I-regulated noncytolytic and cytolytic interactions
42. Differential clustering of CD4 and CD3ζ during T cell recognition
43. T cell receptor signaling precedes immunological synapse formation
44. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse
45. The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation
46. Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin
47. ICAM-2 redistributed by ezrin as a target for killer cells
48. + T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells
49. Lipid rafts and signal transduction
50. Lipid domains in membranes. Evidence derived from structural perturbations induced by free fatty acids and lifetime heterogeneity analysis
51. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
52. T lymphocyte costimulation mediated by reorganization of membrane microdomains
53. Lipid raft heterogeneity in human peripheral blood T lymphoblasts: A mechanism for regulating the initiation of TCR signal transduction
54. Trafficking of spontaneously endocytosed MHC proteins
55. Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation
56. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor
57. Lipid microdomain clustering induces a redistribution of antigen recognition and adhesion molecules on human T lymphocytes
58. Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: Accumulation of actin regulated by local tyrosine phosphorylation
59. Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function
60. Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells
61. Cutting edge: Negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly
62. Physiological regulation of the immunological synapse by agrin
63. Immunoglobulin and cytokine expression in mixed lymphocyte cultures is reduced by disruption of gap junction intercellular communication
64. Rafts and synapses in the spatial organization of immune cell signaling receptors
65. Lipid rafts and B-cell activation
66. Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation
67. Distinct patterns of membrane microdomain partitioning in Th1 and Th2 cells
68. B cells acquire antigen from target cells after synapse formation
69. A balance between positive and negative signals in cytotoxic lymphocytes regulates the polarization of lipid rafts during the development of cell-mediated killing
70. Signaling at the inhibitory natural killer cell immune synapse regulates lipid raft polarization but not class I MHC clustering
71. TCR-mediated internalization of peptide-MHC complexes acquired by T cells
72. Cutting edge: CTLs rapidly capture membrane fragments from target cells in a TCR signaling-dependent manner
73. Functional CD4 T cells after intercellular molecular transfer of 0X40 ligand
74. Intercellular transfer of antigen-presenting cell determinants onto T cells: Molecular mechanisms and biological significance
75. Acquisition of external major histocompatibility complex class I molecules by natural killer cells expressing inhibitory Ly49 receptors
76. + natural killer (NK) cells precludes ligand uptake from environmental cells: Implications for NK cell function
77. Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission
78. Water dynamics in glycosphingolipid aggregates studied by laurdan fluorescence
79. Molecular dynamics in living cells observed by fluorescence correlation spectroscopy with one- and two-photon excitation
80. Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane
81. Relationship between absorption intensity and fluorescence lifetime of molecules
82. Environmental control of immunological synapse formation and duration
83. Antigen presentation in extracellular matrix: Interactions of T cells with dendritic cells are dynamic, short lived, and sequential
84. Interaction of T cells with APCs: The serial encounter model
85. Cutting edge: Hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation
86. Adhesion to target cells is disrupted by the killer cell inhibitory receptor
87. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis