Src homology-2 domains: Structure, mechanisms, and drug discovery

Biopolymers

Volumn 47, Issue 3, 1998, Pages 243-261

  Sawyer, Tomi K ^a  

^a ARIAD PHARMACEUTICALS INC   (United States)

Author keywords

Grb2; Nonpeptide; Peptidomimetic; Phosphopeptide; Phosphotyrosine; Protein protein interactions; Signal transduction; Src homology domain; Structure based drug design; Zap70

Indexed keywords

AMINO ACIDS; CELLS; DRUG PRODUCTS; MOLECULAR STRUCTURE;

PHOSPHOPEPTIDE; SIGNAL TRANSDUCTION;

ENZYMES;

NONAPEPTIDE; PEPTIDE LIBRARY; PHOSPHOPEPTIDE; PHOSPHOTYROSINE; PRODRUG; PROTEIN KINASE INHIBITOR; PROTEIN KINASE P60; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR;

CATALYSIS; CELL GROWTH; CELL METABOLISM; CELL MOTILITY; DRUG DESIGN; DRUG SCREENING; DRUG TARGETING; GENETIC TRANSCRIPTION; HUMAN; IMMUNE RESPONSE; MITOGENESIS; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ERRATUM; ERROR;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL PHYSIOLOGY; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS;

EID: 0031796005     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(1998)47:3<243::AID-BIP4>3.0.CO;2-P     Document Type: Article

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