Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit

Journal of Biological Chemistry

Volumn 280, Issue 30, 2005, Pages 27850-27855

  Shekar, S Chandra ^a   Wu, Haiyan ^a   Fu, Zheng ^a   Yip, Shu Chin ^a   Nagajyothi, ^a   Cahill, Sean M ^a   Girvin, Mark E ^a   Backer, Jonathan M ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CONFORMATIONS; MATHEMATICAL MODELS; NUCLEAR MAGNETIC RESONANCE; TUMORS;

DOMAIN PACKS; HUMAN CANCERS; ONCOGENIC MUTANTS; REGULATORY INTERACTIONS;

BIOCHEMISTRY;

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; PROTEIN SH2; RECOMBINANT PROTEIN; SYNAPTOTAGMIN;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPHOSPHORYLATION; CELL FUNCTION; ENZYME ACTIVATION; ENZYME SUBUNIT; GENE DISRUPTION; GENE MUTATION; MALIGNANT TRANSFORMATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BINDING SITES; ENZYME ACTIVATION; GLUTATHIONE TRANSFERASE; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHENOTYPE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SERINE; SRC HOMOLOGY DOMAINS;

MURINAE;

EID: 23044467557     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M506005200     Document Type: Article

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