Alternative modes of binding of proteins with tandem SH2 domains

Protein Science

Volumn 9, Issue 3, 2000, Pages 570-579

  O'Brien, Ronan ^a   Rugman, Paul ^b   Renzoni, Debora ^a   Layton, Meredith ^c   Handa, Raj ^b   Hilyard, Kate ^b   Waterfield, Michael D ^a,c   Driscoll, Paul C ^a,c   Ladbury, John E ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ROCHE PRODUCTS LTD   (United Kingdom)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

Isothermal titration calorimetry; Phosphotyrosine; Receptor interaction; Specificity; Tandem Src homology domains

Indexed keywords

PROTEIN KINASE P60; PROTEIN TYROSINE KINASE;

ARTICLE; ENZYME SPECIFICITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

EID: 0034067787     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.9.3.570     Document Type: Article

References (36)

1. + thymic selection in humans lacking ZAP-70 kinase. Cell 76:947-958.
2. Booker GW, Breeze AL, Downing AK, Panayotou G, Gout I. Waterfield MD, Campbell ID. 1992. Structure of an SH2 domain of the p85α subunit of phosphatidylinositol-3-OH kinase. Nature 358:684-687.
3. Bradshaw JM, Grucza RA, Ladbury JE, Waksman G. 1998. Probing the "two-pronged plug two-holed socket" model for the mechanism of binding of the Src SH2 domain to phosphotyrosyl peptides: A thermodynamic study. Biochemistry 37:9083-9090.
4. Breeze AL, Kara BV, Barratt DG, Anderson M, Smith JC, Luke RW, Best JR, Cartlidge SA. 1996. Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85α subunit of phosphatidylinositol-3 kinase. EMBO J 15:3579-3589.
5. Chan AC, Kadlecek TA, Elder ME, Filipovich AH, Kuo WL, Iwashima M, Parslow TG, Weiss A. 1994. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science 264:1599-1601.
6. Chung E, Henriques D, Renzoni D, Zvelebil M, Bradshaw JM, Waksman G, Robinson CV, Ladbury JE. 1998. Mass spectrometric and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides. Structure 6:1141-1151.
7. Delaglio F, Grzesisek S, Vuister GW, Zhu G, Pfeifer J, Bax A. 1995. NMRpipe - A multidimensional spectral processing system based on UNIX pipes. J Biomol NMR 6:277-293.
8. Dhand R, Hara K, Miles I, Bax B, Gout I, Panayotou G, Fry MJ, Yonezawa K, Kasuga M, Waterfield MD. 1994. PI 3-kinase: Structural and functional analysis of inter-subunit interactions. EMBO J 13:511-521.
9. Elder ME, Lin D, Clever J, Chan AC, Hope TJ, Weiss A, Parslow TG. 1994. Human severe combined immunodeficiency due to a defect ZAP-70, a T-cell tyrosine kinase. Science 264:1596-1599.
10. Escobedo JA, Kaplan DR, Kavanaugh WM, Turck CW, Williams LT. 1991. A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine. Mol Cell Biol 11:1125-1132.
11. Fruman DA, Snapper SB, Yballe CM, Davidson L, Yu JY, Alt FW, Cantley LC. 1999. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α. Science 283:393-397.
12. Fütterer K, Wong J, Grucza RA, Chan AC, Waksman G. 1998 Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide. J Mol Biol 281:523-533.
13. Graef IA, Holsinger LJ, Diver S, Schreiber SL, Crabtree GR. 1997. Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70. EMBO J 16:5618-5628.
14. Grazioli L, Germain V, Weiss A, Acuto O. 1998. Anti-peptide antibodies detect conformational changes of the inter-SH2 domain of ZAP-70 due to binding to the ζ chain and to intramolecular interactions. J Biol Chem 273:8916-8921.
15. Grucza RA, Fütterer K, Chan AC, Waksman G. 1999. Thermodynamic study of the binding of the tandem-SH2 domain of the Syk kinase to a dually phosphorylated ITAM peptide: Evidence for two conformers. Biochemistry 38:5024-5033.
16. Hatada MH, Lu X, Laird ER, Green J, Morgenstern JP, Lou M, Marr CS, Phillips TB, Ram MK, Therialt K, et al. 1995. Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor. Nature 377:32-38.
17. Krugh TR. 1979. Spin-label-induced nuclear relaxation studies of enzymes. In: Berliner L, ed. Spin labeling. II. Theory and applications. New York: Academic Press, pp 339-372.
18. Kuriyan J, Cowburn D. 1997. Modular peptide recognition domains in eukaryotic signaling. Annu Rev Biophys Biomol Struct 26:828-837.
19. Labadia ME, Jakes S, Grygon CA, Greenwood DG, Schembri-King J, Lukas SM, Warren TC, Ingraham RH. 1997. Interaction between the SH2 domains of ZAP-70 and the tyrosine-based activation motif 1 sequence of the zeta subunit of the T-cell receptor. Arch Biochem Biophys 342:117-125.
20. Ladbury JE, Arold S. 2000. Searching for specificity in SH domains. Chem Biol 7:R3-R8.
21. Ladbury JE, Chowdhry BZ. 1996. Sensing the heat: The application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions. Chem Biol 3:791-801.
22. Ladbury JE, Hensmann M, Panayotou G, Campbell ID. 1996 Alternative modes of tyrosyl phosphopeptide binding to a Src family SH2 domain: Implications for regulation. Biochemistry 35:11062-11069.
23. lck. Biochemistry 33:5070-5076.
24. 19 NMR studies of the D-galactose chemosensory receptor. 1. Sugar binding yields a global structural change. Biochemistry 30:4248-4256.
25. Nicholls A, Sharp KA, Honig B. 1991. Protein folding and association-insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins Struct Fund Genet 11:281-296.
26. Nolte RT, Eck MJ, Schlessinger J, Shoelson SE, Harrison SC. 1996. Crystal structure of the P13-kinase p85 amino-terminal and its phosphopeptide complexes. Nat Struct Biol 3:364-373.
27. Ottinger EA, Botfield MC, Shoelson SE. 1998. Tandem SH2 domains confer high specificity in tyrosine kinase signaling. J Biol Chem 273:729-735.
28. Panayotou G, Gish G, End P, Truong O, Gout I. Dhand R, Fry MJ, Hiles I, Pawson T, Waterfield MD. 1993. Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor β-receptor sequences: Analysis of kinetic parameters by a novel biosensor-based approach. Mol Cell Biol 13:3567-3576.
29. Pawson T. 1995. Protein modules and signaling networks. Nature 373:573-580.
30. Renzoni DA, Zvelibil MJJM, Lundbäck T, Ladbury JE. 1997. Exploring uncharted waters: Water molecules in drug design strategies. In: Ladbury JE, Connelly PR, eds. Structure-based drug design: Thermodynamics, modeling and strategy. Austin, TX: RG Landes, pp 161-180.
31. Rordorf-Nikolic T, Van Horn D, Chen D, White M, Backer JM. 1995. Regulation of phosphatidylinositol 3′-kinase by tyrosyl phosphoproteins. J Biol Chem 270:3662-3666.
32. Siegal G, Davis B, Kristensen SM, Sankar A, Linacre J, Stein RC, Panayotou G, Waterfield MD, Driscoll PC. 1998. Solution structure of the C-terminal SH2 domain of the p85α regulatory subunit of phosphoinositide 3-kinase. J Mol Biol 276:461-478.
33. Songyang Z, Shoelson SE, Chaushuri M, Gish G, Pawson T, Haser W, King F, Roberts T, Ratnofsky S, Lechleider RJ, et al. 1993. SH2 domains recognize specific phosphopeptide sequences. Cell 72:767-778.
34. Smith DB, Johnson KS. 1988. Single step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31-40.
35. Waksman G, Shoelson SE, Pant N, Cowburn D, Kuriyan J. 1993. Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms. Cell 72:779-790.
36. Yu J, Wjasow C, Backer JM. 1998. Regulation of the p85/p110α phosphatidylinositol 3′-kinase. J Biol Chem 273:30199-30203.