NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site

Biochemistry

Volumn 39, Issue 51, 2000, Pages 15860-15869

  Weber, T ^a   Schaffhausen, B ^b   Liu, Y ^b   Gunther U L ^a  

^a GOETHE UNIVERSITY   (Germany)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTYROSINE; PROTEIN P85; PROTEIN SUBUNIT; VIRUS ANTIGEN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; POLYOMA VIRUS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; ANTIGENS, POLYOMAVIRUS TRANSFORMING; BINDING SITES; LIGANDS; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PEPTIDES; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SOLUTIONS; SRC HOMOLOGY DOMAINS; TEMPERATURE; THERMODYNAMICS;

EID: 0034719139     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi001474d     Document Type: Article

References (73)