The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 6, 2003, Pages 3275-3280

  Fu, Zheng ^a   Aronoff Spencer, Eliah ^a   Backer, Jonathan M ^a   Gerfen, Gary J ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Distance measurement; Nitroxide; P110; P85; SDSL EPR

Indexed keywords

INOSITOL; NITROXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPEPTIDE; PROTEIN; PROTEIN P110; PROTEIN P85; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CATALYSIS; ELECTRON SPIN RESONANCE; ENZYME SUBUNIT; HUMAN; MOLECULAR DYNAMICS; MOLECULAR MODEL; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN STABILITY; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SPIN LABELING; SRC HOMOLOGY 2 DOMAIN; SRC HOMOLOGY DOMAIN;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ELECTRON SPIN RESONANCE SPECTROSCOPY; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PROTEIN SUBUNITS; RECOMBINANT FUSION PROTEINS; SPIN LABELS; SRC HOMOLOGY DOMAINS; THERMODYNAMICS;

EID: 0037452980     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0535975100     Document Type: Article

References (40)

1. Cantley, L. C. (2002) Science 296, 1655-1657.
2. Yu, J., Zhang, Y., McIlroy, J., Rordoff-Nikolic, T., Orr, G. A. & Backer, J. M. (1998) Mol. Cell. Biol. 18, 1379-1387.
3. Vanhaesebroeck, B., Leevers, S. J., Ahmadi, K. Timms, J., Katso, R., Driscoll, P. C., Woscholski, R., Parker, P. J. & Waterfield, M. D. (2001) Annu. Rev. Biochem. 70, 535-602.
4. Fruman, D. A., Meyers, R. E. & Cantley, L. C. (1998) Annu. Rev. Biochem. 67, 481-507.
5. Hill, K. M., Huang, Y., Yip, S. C., Yu, J., Segall, J. E. & Backer, J. M. (2001) J. Biol. Chem. 276, 16374-16378.
6. Dhand, R., Hara, K., Hiles, I., Bax, B., Gout, I., Panayotou, G., Fry, M. J., Yonezawa, K., Kasuga, M. & Waterfield, M. D. (1994) EMBO J. 13, 511-521.
7. O'Brien, R., Rugman, P., Renzoni, D., Layton, M., Handa, R., Hilyard, K., Waterfield, M. D., Driscoll, P. C. & Ladbury, J. E. (2000) Protein Sci. 9, 570-579.
8. Backer, J. M., Myers, M. G., Jr., Shoelson, S. E., Chin, D. J., Sun, X. J., Miralpeix, M., Hu, P., Margolis, B., Skolnik, E. Y., Schlessinger, J., et al. (1992) EMBO J. 11, 3469-3479.
9. Carpenter, C. L., Auger, K. R., Duckworth, B. C., Hou, W. M., Schaffhausen, B. & Cantley, L. C. (1993) Mol. Cell. Biol. 13, 1657-1665.
10. Yu, J., Wjasow, C. & Backer, J. M. (1998) J. Biol. Chem. 273, 30199-203.
11. Holt, K. H., Olson, L., Moye-Rowley, W. S. & Pessin, J. E. (1994) Mol. Cell. Biol. 14, 42-49.
12. Klippel, A., Escobedo, J. A., Hu, Q. & Williams, L. T. (1993) Mol. Cell. Biol. 13, 5560-5566.
13. Nolte, R. T., Eck, M. J., Schlessinger, J., Shoelson, S. E. & Harrison, S. C. (1996) Nat. Struct. Biol. 3, 364-374.
14. Hensmann, M., Booker, G. W., Panayotou, G., Boyd, J., Linacre, J., Waterfield, M. & Campbell, I. D. (1994) Protein Sci. 3, 1020-1030.
15. Langen, R., Oh, K. J., Cascio, D. & Hubbell, W. L. (2000) Biochemistry 39, 8396-8405.
16. McHaourab, H. S., Lietzow, M. A., Hideg, K. & Hubbell, W. L. (1996) Biochemistry 35, 7692-7704.
17. Hubbell, W. L., Cafiso, D. S. & Altenbach, C. (2000) Nat. Struct. Biol. 7, 735-739.
18. Sali, A. (1995) Curr. Opin. Biotechnol. 6, 437-451.
19. Sali, A. (1995) Mol. Med. Today 1, 270-277.
20. Brown, L. J., Sale, K. L., Hills, R., Rouviere, C., Song, L., Zhang, X. & Fajer, P. G. (2002) Proc. Natl. Acad. Sci. USA 99, 12765-12770.
21. Xiao, W., Poirier, M. A., Bennett, M. K. & Shin, Y. K. (2001) Nat. Struct. Biol. 8, 308-311.
22. Poirier, M. A., Xiao, W., Macosko, J. C., Chan, C., Shin, Y. K. & Bennett, M. K. (1998) Nat. Struct. Biol. 5, 765-769.
23. Berliner, L. J., Grunwald, J., Hankovszky, H. O. & Hideg, K. (1982) Anal. Biochem. 119, 450-455.
24. Altenbach, C., Oh, K. J., Trabanino, R. J., Hideg, K. & Hubbell, W. L. (2001) Biochemistry 40, 15471-15482.
25. Soelaiman, S., Jakes, K., Wu, N., Li, C. & Shoham, M. (2001) Mol. Cell 8, 1053-1062.
26. Constantine, K. L. (2001) Biophys. J. 81, 1275-1284.
27. Nilges, M., Gronenborn, A. M., Brunger, A. T. & Clore, G. M. (1988) Protein Eng. 2, 27-38.
28. Rabenstein, M. D. & Shin, Y. K. (1995) Proc. Natl. Acad. Sci. USA 92, 8239-8243.
29. Press, W. H. (2000) Numerical Recipes in C the Art of Scientific Computing (Cambridge Univ. Press, New York), 2nd Ed.
30. Berliner, L. J., Eaton, G. R. & Eaton, S. S. (2000) Distance Measurements in Biological Systems by EPR, Biological Magnetic Resonance (Kluwer Academic/ Plenum, New York), Vol 19.
31. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., et al. (1998) Acta Crystallogr. D 54, 905-921.
32. Isas, J. M., Langen, R., Haigler, H. T. & Hubbell, W. L. (2002) Biochemistry 41, 1464-1473.
33. Steinhoff, H. J., Radzwill, N., Thevis, W., Lenz, V., Brandenburg, D., Antson, A., Dodson, G. & Wollmer, A. (1997) Biophys. J. 73, 3287-3298.
34. Crick, F. H. C. (1953) Acta Crystallogr. 6, 689-697.
35. Lupas, A. (1996) Methods Enzymol. 266,
36. Gunther, U. L., Liu, Y., Sanford, D., Bachovchin, W. W. & Schaffhausen, B. (1996) Biochemistry 35, 15570-15581.
37. Hof, P., Pluskey, S., Dhe-Paganon, S., Eck, M. J. & Shoelson, S. E. (1998) Cell 92, 441-450.
38. Chan, T. O., Rodeck, U., Chan, A. M., Kimmelman, A. C., Rittenhouse, S. E., Panayotou, G. & Tsichlis, P. N. (2002) Cancer Cell 1, 181-191.
39. Jimenez, C., Jones, D. R., Rodriguez-Viciana, P., Gonzalez-Garcia, A., Leonardo, E., Wennstrom, S., von Kobbe, C., Toran, J. L., R-Borlado, L., Calvo, V., et al. (1998) EMBO J. 17, 743-753.
40. Jimenez, C., Hernandez, C., Pimentel, B. & Carrera, A. C. (2002) J. Biol. Chem. 277, 41556-41562.