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Volumn 47, Issue 1, 2005, Pages 39-51

From stem cells to insulin-producing cells: Towards a bioartificial endocrine pancreas

Author keywords

Cell therapy; Diabetes mellitus; Stem cells

Indexed keywords

INSULIN;

EID: 22144482014     PISSN: 00310808     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (9)

References (72)
  • 2
    • 0030890588 scopus 로고    scopus 로고
    • Cell death mediators in autoimmune diabetes - No shortage of suspects
    • Benoist C, Mathis D. Cell death mediators in autoimmune diabetes - No shortage of suspects. Cell 1997;89:1-3.
    • (1997) Cell , vol.89 , pp. 1-3
    • Benoist, C.1    Mathis, D.2
  • 3
    • 0035856952 scopus 로고    scopus 로고
    • Cell death during progression to diabetes
    • Mathis D, Vence L, Benoist C. _-Cell death during progression to diabetes. Nature 2001;414:792-8.
    • (2001) Nature , vol.414 , pp. 792-798
    • Mathis, D.1    Vence, L.2    Benoist, C.3
  • 4
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001;414:813-20.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 5
    • 0035936763 scopus 로고    scopus 로고
    • New perspectives into the molecular pathogenesis and treatment of type 2 diabetes
    • Saltiel AR. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 2001;104:517.29.
    • (2001) Cell , vol.104
    • Saltiel, A.R.1
  • 6
    • 0035856943 scopus 로고    scopus 로고
    • Diabetes mellitus and genetically programmed defects in _.cell function
    • Bell GI, Polonsky KS. Diabetes mellitus and genetically programmed defects in _.cell function. Nature 2001;414:788.91.
    • (2001) Nature , vol.414
    • Bell, G.I.1    Polonsky, K.S.2
  • 7
    • 0033942001 scopus 로고    scopus 로고
    • Insulin action and insulin resistance in human skeletal muscle
    • Zierath JR, Krook A, Wallberg-Henriksson H. Insulin action and insulin resistance in human skeletal muscle. Diabetologia 2000;43:821-35.
    • (2000) Diabetologia , vol.43 , pp. 821-835
    • Zierath, J.R.1    Krook, A.2    Wallberg-Henriksson, H.3
  • 8
    • 0029691864 scopus 로고    scopus 로고
    • An integrated view of b-cell dysfunction in type 2 diabetes
    • Poitout V, Robertson RP. An integrated view of b-cell dysfunction in type 2 diabetes. Annu Rev Med 1996;47:69-83.
    • (1996) Annu Rev Med , vol.47 , pp. 69-83
    • Poitout, V.1    Robertson, R.P.2
  • 9
    • 0003180141 scopus 로고    scopus 로고
    • Glucotoxicity, lipotoxicity and pancreatic b-cell failure: A role for malonyl-CoA, PPARa and altered lipid partitioning?
    • Prentki M, Roduit R, Lameloise N, Corkey BE, Assimacopoulos-Jeannet F. Glucotoxicity, lipotoxicity and pancreatic b-cell failure: a role for malonyl-CoA, PPARa and altered lipid partitioning? Can J Diabetes Care 2000;25:36-46.
    • (2000) Can J Diabetes Care , vol.25 , pp. 36-46
    • Prentki, M.1    Roduit, R.2    Lameloise, N.3    Corkey, B.E.4    Assimacopoulos-Jeannet, F.5
  • 10
    • 22144480060 scopus 로고    scopus 로고
    • Type 2 diabetes: Gluco-lipo-toxicity and pancreatic b-cell dysfunction
    • Roche E. Type 2 diabetes: gluco-lipo-toxicity and pancreatic b-cell dysfunction. Ars Pharmaceutica 2003;44:313-32.
    • (2003) Ars Pharmaceutica , vol.44 , pp. 313-332
    • Roche, E.1
  • 11
    • 0034721255 scopus 로고    scopus 로고
    • Islet transplantation in seven patients with type 1 diabetes mellitus using a corticoid-free immunosuppressive regime
    • Shapiro AMJ, Lakey JRT, Ryan EA, Korbutt GS, Toth E, Warnock GL et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a corticoid-free immunosuppressive regime. N Eng J Med 2000;343:230-8.
    • (2000) N Eng J Med , vol.343 , pp. 230-238
    • Shapiro, A.M.J.1    Lakey, J.R.T.2    Ryan, E.A.3    Korbutt, G.S.4    Toth, E.5    Warnock, G.L.6
  • 12
    • 0035189927 scopus 로고    scopus 로고
    • Embryo-derived stem cells: Of mice and men
    • Smith AG. Embryo-derived stem cells: of mice and men. Annu Rev Cell Dev Biol 2001;17:435-62.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 435-462
    • Smith, A.G.1
  • 13
    • 1642603951 scopus 로고    scopus 로고
    • Socializing with the neighbors: Stem cells and their niche
    • Fuchs E, Tumbar T, Guasch G. Socializing with the neighbors: stem cells and their niche. Cell 2004;116:769-78.
    • (2004) Cell , vol.116 , pp. 769-778
    • Fuchs, E.1    Tumbar, T.2    Guasch, G.3
  • 14
    • 0001884951 scopus 로고
    • Culture and differentiation of embryonic stem cells
    • Smith AG, Culture and differentiation of embryonic stem cells. J Tissue Cult Methods 1991;13:89-94.
    • (1991) J Tissue Cult Methods , vol.13 , pp. 89-94
    • Smith, A.G.1
  • 16
    • 0035057914 scopus 로고    scopus 로고
    • From stem cells to beta cells: New strategies in cell therapy of diabetes mellitus
    • Spria B, Skoudy A, Martín F. From stem cells to beta cells: new strategies in cell therapy of diabetes mellitus. Diabetologia 2001;44:407-15.
    • (2001) Diabetologia , vol.44 , pp. 407-415
    • Spria, B.1    Skoudy, A.2    Martín, F.3
  • 17
    • 0035906902 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets
    • Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 2001;292:1389-94.
    • (2001) Science , vol.292 , pp. 1389-1394
    • Lumelsky, N.1    Blondel, O.2    Laeng, P.3    Velasco, I.4    Ravin, R.5    McKay, R.6
  • 18
    • 0037417958 scopus 로고    scopus 로고
    • Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells
    • Blyszczuk P, Czyz J, Kania G, Wagner M, Roll U, St-Onge L et al. Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc Natl Acad Sci USA 2003;100:998-1003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 998-1003
    • Blyszczuk, P.1    Czyz, J.2    Kania, G.3    Wagner, M.4    Roll, U.5    St-Onge, L.6
  • 20
    • 0037322489 scopus 로고    scopus 로고
    • Locally born olfactory bulb stem cells proliferate in response to insulin-related factors and require endogenous insulin-like growth factor-I for differentiation into neurons and glia
    • Vicario-Abejón C, Yusta-Boyo MJ, Fernández-Moreno C, de Pablo F. Locally born olfactory bulb stem cells proliferate in response to insulin-related factors and require endogenous insulin-like growth factor-I for differentiation into neurons and glia. J Neurosci 2003:23:895-906.
    • (2003) J Neurosci , vol.23 , pp. 895-906
    • Vicario-Abejón, C.1    Yusta-Boyo, M.J.2    Fernández-Moreno, C.3    De Pablo, F.4
  • 21
    • 0036210550 scopus 로고    scopus 로고
    • Regulation of insulin gene transcription
    • Melloul D, Marshak S, Cerasi E. Regulation of insulin gene transcription. Diabetologia 2002;45:309-26.
    • (2002) Diabetologia , vol.45 , pp. 309-326
    • Melloul, D.1    Marshak, S.2    Cerasi, E.3
  • 23
    • 0037313844 scopus 로고    scopus 로고
    • Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
    • ing Q-L, Stavridis M, Griffiths D, Li M, Smith A. Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol 2003;21:183-6.
    • (2003) Nat Biotechnol , vol.21 , pp. 183-186
    • Ing, Q.-L.1    Stavridis, M.2    Griffiths, D.3    Li, M.4    Smith, A.5
  • 24
    • 0027398295 scopus 로고
    • Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo
    • Deltour L, Leduque P, Blume N, Madsen O, Dubois P, Jami J et al. Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo. Proc Natl Acad Sci USA 1993;90:527-31.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 527-531
    • Deltour, L.1    Leduque, P.2    Blume, N.3    Madsen, O.4    Dubois, P.5    Jami, J.6
  • 25
    • 0025641727 scopus 로고
    • Stem cells: Attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt
    • Potten CS, Loeffler M. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 1990;110:1001-20.
    • (1990) Development , vol.110 , pp. 1001-1020
    • Potten, C.S.1    Loeffler, M.2
  • 27
    • 0034100823 scopus 로고    scopus 로고
    • Reversal of insulin-dependent diabtes using islets generated in vitro from pancreatic stem cells
    • Ramiya VK, Maraist M, Arfors KE, Schatz DA, Peck AB, Cornelius JG. Reversal of insulin-dependent diabtes using islets generated in vitro from pancreatic stem cells. Nat Med 2000;6:278-82.
    • (2000) Nat Med , vol.6 , pp. 278-282
    • Ramiya, V.K.1    Maraist, M.2    Arfors, K.E.3    Schatz, D.A.4    Peck, A.B.5    Cornelius, J.G.6
  • 28
    • 0035119871 scopus 로고    scopus 로고
    • Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine and hepatic phenotypes
    • Zulewski H, Abraham EJ, Gerlach MJ, Daniel PB, Moritzs W, Müller B et al. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine and hepatic phenotypes. Diabetes 2001;50:521-33.
    • (2001) Diabetes , vol.50 , pp. 521-533
    • Zulewski, H.1    Abraham, E.J.2    Gerlach, M.J.3    Daniel, P.B.4    Moritzs, W.5    Müller, B.6
  • 29
    • 0141643297 scopus 로고    scopus 로고
    • Nestin-lineage cells contribute to the microvasculature but not endocrine cells of the islet
    • Treutelaar MK, Skidmore JM, Dias-Leme CL, Hara M, Zhang L, Simeone D et al. Nestin-lineage cells contribute to the microvasculature but not endocrine cells of the islet. Diabetes 2003:52:2503-12.
    • (2003) Diabetes , vol.52 , pp. 2503-2512
    • Treutelaar, M.K.1    Skidmore, J.M.2    Dias-Leme, C.L.3    Hara, M.4    Zhang, L.5    Simeone, D.6
  • 30
    • 0042413427 scopus 로고    scopus 로고
    • Signals for death and differentiation: A two-step mechanism for in vitro transformation of adult islets of Langerhans to duct epithelial structures
    • Jamal A-M, Lipstt M, Hazrati A, Paraskevas S, Agapitos D, Maysinger D et al. Signals for death and differentiation: a two-step mechanism for in vitro transformation of adult islets of Langerhans to duct epithelial structures. Cell Death Diff 2003;10:987-96.
    • (2003) Cell Death Diff , vol.10 , pp. 987-996
    • Jamal, A.-M.1    Lipstt, M.2    Hazrati, A.3    Paraskevas, S.4    Agapitos, D.5    Maysinger, D.6
  • 31
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic _-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y, Brown J, Martínez OI, Melton DA. Adult pancreatic _-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004;429:41-6.
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martínez, O.I.3    Melton, D.A.4
  • 33
    • 0037364517 scopus 로고    scopus 로고
    • In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion
    • Ianus A, Holz GG, Theise ND, Hussain MA. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 2003;111:843-50.
    • (2003) J Clin Invest , vol.111 , pp. 843-850
    • Ianus, A.1    Holz, G.G.2    Theise, N.D.3    Ma, H.4
  • 34
    • 10744233909 scopus 로고    scopus 로고
    • Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells
    • Choi JB, Uchino H, Azuma K, Iwashita N, Tanaka Y, Mochizuki H et al Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia 2003;46:1366-74.
    • (2003) Diabetologia , vol.46 , pp. 1366-1374
    • Choi, J.B.1    Uchino, H.2    Azuma, K.3    Iwashita, N.4    Tanaka, Y.5    Mochizuki, H.6
  • 35
    • 1442326000 scopus 로고    scopus 로고
    • No evidence for significant transdifferentiation of bone marrow into pancreatic β-cells in vivo
    • Lechner A, Yang Y-G, Blacken RA, Wang L, Nolan AL, Habener JF. No evidence for significant transdifferentiation of bone marrow into pancreatic β-cells in vivo. Diabetes 2004:53:616-23.
    • (2004) Diabetes , vol.53 , pp. 616-623
    • Lechner, A.1    Yang, Y.-G.2    Blacken, R.A.3    Wang, L.4    Nolan, A.L.5    Habener, J.F.6
  • 36
    • 1542328965 scopus 로고    scopus 로고
    • Plasticity of adult stem cells
    • Wagers AJ, Weissman IL. Plasticity of adult stem cells. Cell 2004:116:639-48.
    • (2004) Cell , vol.116 , pp. 639-648
    • Wagers, A.J.1    Weissman, I.L.2
  • 37
    • 0035913986 scopus 로고    scopus 로고
    • Induction of pancreatic differentiation by signals from blood vessels
    • Lammert E, Cleaver O, Melton D. Induction of pancreatic differentiation by signals from blood vessels. Science 2001;294:564-7.
    • (2001) Science , vol.294 , pp. 564-567
    • Lammert, E.1    Cleaver, O.2    Melton, D.3
  • 38
    • 0035863135 scopus 로고    scopus 로고
    • Intercellular signals regulating pancreas development and function
    • Kim SK, Hebrok M. Intercellular signals regulating pancreas development and function. Genes Dev 2001;15:111-27.
    • (2001) Genes Dev , vol.15 , pp. 111-127
    • Kim, S.K.1    Hebrok, M.2
  • 39
    • 0037820427 scopus 로고    scopus 로고
    • Bone marrow-derived stem cells initiate pancreatic regeneration
    • Hess D, Li L, Martin M, Sakano S, Hill D, Strutt B et al. Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotech 2003:21:763-70.
    • (2003) Nat Biotech , vol.21 , pp. 763-770
    • Hess, D.1    Li, L.2    Martin, M.3    Sakano, S.4    Hill, D.5    Strutt, B.6
  • 40
    • 0037062515 scopus 로고    scopus 로고
    • In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells
    • Yang L, Li S, Hatch H, Ahrens K, Cornelius JG, Petersen BE et al. In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc Natl Acad Sci USA 2002:99:8078-83.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8078-8083
    • Yang, L.1    Li, S.2    Hatch, H.3    Ahrens, K.4    Cornelius, J.G.5    Petersen, B.E.6
  • 41
    • 0034068602 scopus 로고    scopus 로고
    • Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
    • Ferber S, Halkin A, Cohen H, Ber I, Einav Y, Goldberg I et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 2000:6:568-72.
    • (2000) Nat Med , vol.6 , pp. 568-572
    • Ferber, S.1    Halkin, A.2    Cohen, H.3    Ber, I.4    Einav, Y.5    Goldberg, I.6
  • 42
    • 0038413922 scopus 로고    scopus 로고
    • NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice
    • Kojima H, Fujimiya M, Matsumura K, Younan P, Imaeda, H, Maeda M et al. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med 2003;9:596-603.
    • (2003) Nat Med , vol.9 , pp. 596-603
    • Kojima, H.1    Fujimiya, M.2    Matsumura, K.3    Younan, P.4    Imaeda, H.5    Maeda, M.6
  • 43
    • 0038472015 scopus 로고    scopus 로고
    • Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells
    • Zalzman M, Gupta S, Giri RK, Berkovich I, Sappal BS, Karnieli O et al. Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells. Proc Natl Acad Sci USA 2003;100:7253-8.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7253-7258
    • Zalzman, M.1    Gupta, S.2    Giri, R.K.3    Berkovich, I.4    Sappal, B.S.5    Karnieli, O.6
  • 45
    • 0042883971 scopus 로고    scopus 로고
    • The use of gating technology in bioengineering insulin-secreting cells from embryonic stem cells
    • Roche E, Burcin MM, Esser S, Rüdiger M, Soria B. The use of gating technology in bioengineering insulin-secreting cells from embryonic stem cells. Cytotechnology 2003;41:145-51.
    • (2003) Cytotechnology , vol.41 , pp. 145-151
    • Roche, E.1    Burcin, M.M.2    Esser, S.3    Rüdiger, M.4    Soria, B.5
  • 46
    • 0033979603 scopus 로고    scopus 로고
    • Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice
    • Soria B, Roche E, Berná G, León-Quinto T, Reig JA, Martin F. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 2000;49:157-62.
    • (2000) Diabetes , vol.49 , pp. 157-162
    • Soria, B.1    Roche, E.2    Berná, G.3    León-Quinto, T.4    Reig, J.A.5    Martin, F.6
  • 47
    • 0030016231 scopus 로고    scopus 로고
    • Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts
    • Klug MG, Soonpa MH, Koh GY, Field LJ. Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts. J Clin Invest 1996;98:216-24.
    • (1996) J Clin Invest , vol.98 , pp. 216-224
    • Klug, M.G.1    Soonpa, M.H.2    Koh, G.Y.3    Field, L.J.4
  • 48
    • 0032572734 scopus 로고    scopus 로고
    • Generation of purified neural precursors from embryonic stem cells by lineage selection
    • Li M, Pevny L, Lovell-Badge R, Smith A. Generation of purified neural precursors from embryonic stem cells by lineage selection. Curr Biol 1998;8:971-4.
    • (1998) Curr Biol , vol.8 , pp. 971-974
    • Li, M.1    Pevny, L.2    Lovell-Badge, R.3    Smith, A.4
  • 49
    • 0035487293 scopus 로고    scopus 로고
    • Recombineering: A powerful new tool for mouse functional genomics
    • Copeland NG, Jenkins NA, Court DL. Recombineering: a powerful new tool for mouse functional genomics. Nat Genetics 2001;2:769-79.
    • (2001) Nat Genetics , vol.2 , pp. 769-779
    • Copeland, N.G.1    Jenkins, N.A.2    Court, D.L.3
  • 50
    • 4544310572 scopus 로고    scopus 로고
    • In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells
    • León-Quinto T, Jones J, Skoudy A, Burcin M, Soria B. In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells. Diabetologia 2004;47:1442-51.
    • (2004) Diabetologia , vol.47 , pp. 1442-1451
    • León-Quinto, T.1    Jones, J.2    Skoudy, A.3    Burcin, M.4    Soria, B.5
  • 51
    • 0034869475 scopus 로고    scopus 로고
    • High-yield selection and extraction of two promoter-defined phenotypes of neuronal stem cells from the fetal human brain
    • Keyoung HM, Roy NS, Benraiss A, Louissaint Jr A, Suzuki A, Hashimoto M et al. High-yield selection and extraction of two promoter-defined phenotypes of neuronal stem cells from the fetal human brain. Nature Biotech 2001;19:843-50.
    • (2001) Nature Biotech , vol.19 , pp. 843-850
    • Keyoung, H.M.1    Roy, N.S.2    Benraiss, A.3    Louissaint Jr., A.4    Suzuki, A.5    Hashimoto, M.6
  • 52
    • 18844480439 scopus 로고    scopus 로고
    • Junctional communication of pancreatic b-cells contributes to the control of insulin secretion and glucose tolerance
    • Charollais A, Gjinovci A, Huarte J, Bauquis J, Nadal A, Martin F et al. Junctional communication of pancreatic b-cells contributes to the control of insulin secretion and glucose tolerance. J Clin Invest 2000:106:235-43.
    • (2000) J Clin Invest , vol.106 , pp. 235-243
    • Charollais, A.1    Gjinovci, A.2    Huarte, J.3    Bauquis, J.4    Nadal, A.5    Martin, F.6
  • 54
    • 0027265403 scopus 로고
    • Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells
    • Otonkoski T, Beattie GM, Mally MI, Ricprdi C, Hayek A. Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells. J Clin Invest 1993;92:1459-66.
    • (1993) J Clin Invest , vol.92 , pp. 1459-1466
    • Otonkoski, T.1    Beattie, G.M.2    Mally, M.I.3    Ricprdi, C.4    Hayek, A.5
  • 55
    • 0036315648 scopus 로고    scopus 로고
    • Beta-cell differentiation during human development does not rely on nestin-positive precursors: Implications for stem cell-derived replacement therapy
    • Piper K, Ball SG, Turnpenny LW, Brickwod S, Wilson DI, Hanley NA. Beta-cell differentiation during human development does not rely on nestin-positive precursors: implications for stem cell-derived replacement therapy. Diabetologia 2002;45:1045-7.
    • (2002) Diabetologia , vol.45 , pp. 1045-1047
    • Piper, K.1    Ball, S.G.2    Turnpenny, L.W.3    Brickwod, S.4    Wilson, D.I.5    Hanley, N.A.6
  • 56
    • 0037058934 scopus 로고    scopus 로고
    • Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells
    • Hori Y, Rulifson IC, Tsai BC, Heit JJ, Cahoy JD, Kim SK. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci USA 2002;99:16105-10.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 16105-16110
    • Hori, Y.1    Rulifson, I.C.2    Tsai, B.C.3    Heit, J.J.4    Cahoy, J.D.5    Kim, S.K.6
  • 57
    • 0042453495 scopus 로고    scopus 로고
    • Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells
    • Moritoh Y, Yamato E, Yasui Y, Miyazaki S, Miyazaki J. Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells. Diabetes 2003;52:1163-8.
    • (2003) Diabetes , vol.52 , pp. 1163-1168
    • Moritoh, Y.1    Yamato, E.2    Yasui, Y.3    Miyazaki, S.4    Miyazaki, J.5
  • 58
    • 1842527497 scopus 로고    scopus 로고
    • Regulated expression of Pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells
    • Miyazaki S, Yamato E, Miyazaki J. Regulated expression of Pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells. Diabetes 2004;53:1030-7.
    • (2004) Diabetes , vol.53 , pp. 1030-1037
    • Miyazaki, S.1    Yamato, E.2    Miyazaki, J.3
  • 59
    • 2942615532 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells into insulin-producing clusters
    • Segev H, Fishman B, Ziskind A, Shulman M, Itskovitz-Eldor J. Differentiation of human embryonic stem cells into insulin-producing clusters. Stem Cells 2004;22:265-74.
    • (2004) Stem Cells , vol.22 , pp. 265-274
    • Segev, H.1    Fishman, B.2    Ziskind, A.3    Shulman, M.4    Itskovitz-Eldor, J.5
  • 61
    • 0036896635 scopus 로고    scopus 로고
    • Regulation of pancreatic b-cell glucokinase. From basics to therapeutics
    • Matschinsky FM. Regulation of pancreatic b-cell glucokinase. From basics to therapeutics. Diabetes 2002; 51 Suppl 3:5394-404.
    • (2002) Diabetes , vol.51 , Issue.3 SUPPL. , pp. 5394-5404
    • Matschinsky, F.M.1
  • 63
    • 0034072556 scopus 로고    scopus 로고
    • Glucose-regulated anaplerosis and cataplerosis in pancreatic b-cells. Possible implication of a pyruvate/citrate shuttle in insulin secretion
    • Farfari S, Schulz V, Corkey B, Prentki M. Glucose-regulated anaplerosis and cataplerosis in pancreatic b-cells. Possible implication of a pyruvate/citrate shuttle in insulin secretion. Diabetes 2000;49:718-26.
    • (2000) Diabetes , vol.49 , pp. 718-726
    • Farfari, S.1    Schulz, V.2    Corkey, B.3    Prentki, M.4
  • 64
    • 0035157768 scopus 로고    scopus 로고
    • Glucose sensing in pancreatic beta-cells: A model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus
    • Schuit FC, Huypens P, Heimberg H, Pipeleers DG. Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Diabetes 2001;50: 1-11.
    • (2001) Diabetes , vol.50 , pp. 1-11
    • Schuit, F.C.1    Huypens, P.2    Heimberg, H.3    Pipeleers, D.G.4
  • 65
    • 0036311144 scopus 로고    scopus 로고
    • Molecular determinants of regulated exocytosis
    • Gerber SH, Südhof TC. Molecular determinants of regulated exocytosis. Diabetes 2002; 51 Suppl 1: S3-11.
    • (2002) Diabetes , vol.51 , Issue.1 SUPPL.
    • Gerber, S.H.1    Südhof, T.C.2
  • 66
    • 0042879951 scopus 로고    scopus 로고
    • Insulin granule dynamics in pancreatic beta cells
    • Rorsman P, Renström E. Insulin granule dynamics in pancreatic beta cells. Diabetologia 2003;46:1029-45.
    • (2003) Diabetologia , vol.46 , pp. 1029-1045
    • Rorsman, P.1    Renström, E.2
  • 67
    • 0033556082 scopus 로고    scopus 로고
    • Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion
    • Lang J. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur J Biochem 1999;259:3-17.
    • (1999) Eur J Biochem , vol.259 , pp. 3-17
    • Lang, J.1
  • 68
    • 0028329930 scopus 로고
    • Sorting and processing of secretory proteins
    • Halban PA, Irminger J-C. Sorting and processing of secretory proteins. Biochem J 1994;299:1-18.
    • (1994) Biochem J , vol.299 , pp. 1-18
    • Halban, P.A.1    Irminger, J.-C.2
  • 69
    • 0036192342 scopus 로고    scopus 로고
    • Considerations for successful transplantation of encapsulated pancreatic islets
    • de Vos P, Hamel AF, Tatarkiewicz K. Considerations for successful transplantation of encapsulated pancreatic islets. Diabetologia 2002;45:159-73.
    • (2002) Diabetologia , vol.45 , pp. 159-173
    • De Vos, P.1    Hamel, A.F.2    Tatarkiewicz, K.3
  • 71
    • 0034837080 scopus 로고    scopus 로고
    • Molecular mechanism to maintain stem cell renewal of ES cells
    • Niwa H. Molecular mechanism to maintain stem cell renewal of ES cells. Cell Struct Funct 2001;26:137-48.
    • (2001) Cell Struct Funct , vol.26 , pp. 137-148
    • Niwa, H.1
  • 72
    • 0034175552 scopus 로고    scopus 로고
    • The mouse homolog of Drosophila Vasa is required for the development of male germ cells
    • Tanaka SS, Toyooka Y, Akasu R, Katoh-Fukui Y, Nakahara Y, Suzuki R et al. The mouse homolog of Drosophila Vasa is required for the development of male germ cells. Genes Dev 2000;14:841-53.
    • (2000) Genes Dev , vol.14 , pp. 841-853
    • Tanaka, S.S.1    Toyooka, Y.2    Akasu, R.3    Katoh-Fukui, Y.4    Nakahara, Y.5    Suzuki, R.6


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