Molecular determinants of regulated exocytosis

Diabetes

Volumn 51, Issue SUPPL., 2002, Pages

  Gerber, Stefan H ^a   Südhof, Thomas C ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SNARE PROTEIN; SYNAPTOTAGMIN;

CALCIUM METABOLISM; CALCIUM TRANSPORT; CONFERENCE PAPER; EXOCYTOSIS; INSULIN RELEASE; MEMBRANE FUSION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0036311144     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.2007.s3     Document Type: Conference Paper

References (85)

1. Intracellular aspects of the process of protein secretion
2. Constitutive and regulated secretion of proteins
3. The role of vesicular transport proteins in synaptic transmission and neural degeneration
4. Role of vesicle recycling in vesicular storage and release of acetylcholine in Torpedo electroplaque synapses
5. 2+
6. Timing of synaptic transmission
7. The synaptic vesicle cycle: A cascade of protein-protein interactions
8. Genetics of synaptic vesicle function: Towards the complete functional anatomy of an organelle
9. Endocrine secretory granules and neuronal synaptic vesicles have three integral membrane proteins in common
10. Membrane fusion and exocytosis
11. Priming in exocytosis: Attaining fusion-competence after vesicle docking
12. Initial docking of ER-derived vesicles requires Uso1p and Ypt1p but is independent of SNARE proteins
13. Defining the functions of trans-SNARE pairs
14. Newly synthesized phosphatidylinositol phosphates are required for synaptic norepinephrine but not glutamate or gamma-aminobutyric acid (GABA) release
15. Membrane tethering and fusion in the secretory and endocytic pathways
16. Yeast homotypic vacuole fusion: A window on organelle trafficking mechanisms
17. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution
18. SNAREs and SNARE regulators in membrane fusion and exocytosis
19. The Croonian Lecture 1999. Intracellular membrane traffic: Getting proteins sorted
20. SNARE-mediated membrane fusion
21. SNAP receptors implicated in vesicle targeting and fusion
22. Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs
23. VAMP-1: A synaptic vesicle-associated integral membrane protein
24. A synaptic vesicle membrane protein is conserved from mammals to
25. The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations
26. Akagawa: A marker of early amacrine cell development in rat retina
27. Cloning and sequence analysis of cDNA for a neuronal cell membrane antigen, HPC-1
28. Syntaxin: A synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones
29. HPC-1 is associated with synaptotagmin and omega-conotoxin receptor
30. Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A
31. A conformational switch in syntaxin during exocytosis: Role of munc18
32. Tetanus toxin action: Inhibition of neurotransmitter release linked to synaptobrevin proteolysis
33. Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
34. Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E
35. Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
36. Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin
37. Proteolysis of SNAP-25 by types E and A botulinal neurotoxins
38. Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond
39. A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast
40. The genetics of Caenorhabditis elegans
41. Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway
42. Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin
43. A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin
44. N-sec1: A neural-specific syntaxin-binding protein
45. A novel ubiquitous form of munc18 interacts with multiple syntaxins
46. Molecular identification of two novel Munc-18 isoforms expressed in non-neuronal tissues
47. Synaptic assembly of the brain in the absence of neurotransmitter secretion
48. Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex
49. Vam 3p structure reveals conserved and divergent properties of syntaxins
50. Functional analysis of conserved structural elements in yeast syntaxin Vam3p
51. The phosphatidylinositol 3-phosphate binding protein Vac1p interacts with a Rab GTPase and a Sec1p homologue to facilitate vesicle-mediated vacuolar protein sorting
52. Small GTP-binding proteins
53. The mammalian Rab family of small GTPases: Definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily
54. Multiple aspects of Rab protein action in the secretory pathway: Focus on Rab3 and Rab6
55. Mechanism and regulation of neurotransmitter release
56. Rab3 and synaptotagmin: The yin and yang of synaptic membrane fusion
57. Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy
58. Structural organization of the synaptic exocytosis core complex
59. The synaptic SNARE complex is a parallel four-stranded helical bundle
60. Synaptic vesicle membrane fusion complex: Action of clostridial neurotoxins on assembly
61. SNAREpins: Minimal machinery for membrane fusion
62. Co-operative action a calcium ions in transmitter release at the neuromuscular junction
63. Fast steps in exocytosis and endocytosis studied by capacitance measurements in endocrine cells
64. 2 domain proteins that regulate membrane traffic
65. Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C
66. Synaptotagmin II: A novel differentially distributed form of synaptotagmin
67. Functional properties of multiple synaptotagmins in brain
68. The subcellular localizations of atypical synaptotagmins: Synaptotagmin III is enriched in synapses and synaptic plasma membranses but not in synaptic vesicles
69. 2+ sensor in exocytosis
70. 2+/phospholipid-binding
71. Progress in membrane fusion: From structure to function
72. Identification of a nonneuronal isoform of synaptotagmin
73. 2+-independent activities of neural and nonneural synaptotagmins
74. A third synaptotagmin gene, Syt3, in the mouse
75. Synaptotagmin III is a novel isoform of rat synaptotagmin expressed in endocrine and neuronal cells
76. Synthesis degradation, and subcellular localization of synaptotagmin IV, a neuronal immediate early gene product
77. Synaptotagmin IV is present at the Golgi and distal parts of neurites
78. Synaptic transmission persists in synaptotagmin mutants of
79. Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release
80. Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin
81. 2+ sensor for transmitter release at a central synapse
82. Synaptotagmin I functions as calcium regulator of release probability
83. Neurotransmitter release from synaptotagmin-deficient clonal variants of PC12 cells
84. Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis