The C-terminal half of Saccharomyces cerevisiae Mad1p mediates spindle checkpoint function, chromosome transmission fidelity and CEN Association

Genetics

Volumn 170, Issue 2, 2005, Pages 509-517

  Kastenmayer, James P ^a   Lee, Marina S ^b   Hong, Andrew L ^a   Spencer, Forrest A ^b   Basrai, Munira A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENOMYL; NOCODAZOLE; PROTEIN MAD1; PROTEIN MAD1P; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CHROMOSOME; FLUORESCENCE MICROSCOPY; FUNGAL STRAIN; GENE DELETION; GENE INTERACTION; GENOMIC INSTABILITY; IMMUNOPRECIPITATION; MICROTUBULE ASSEMBLY; MITOSIS INHIBITION; MITOSIS SPINDLE; NONHUMAN; NUCLEAR PORE COMPLEX; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; WESTERN BLOTTING;

ALLELES; ANAPHASE; BLOTTING, WESTERN; CELL CYCLE; CELL CYCLE PROTEINS; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOMES; EVOLUTION, MOLECULAR; GENE DELETION; GENES, REPORTER; GENOME, FUNGAL; GENOTYPE; GREEN FLUORESCENT PROTEINS; KINETOCHORES; MICROSCOPY, FLUORESCENCE; MITOTIC SPINDLE APPARATUS; MUTATION; NOCODAZOLE; NUCLEAR PROTEINS; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 22144452918     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: 10.1534/genetics.105.041426     Document Type: Article

References (37)

1. BASU, J., H. BOUSBAA, E. LOGARINHO, Z. LI, B. C. WILLIAMS et al., 1999 Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila. J. Cell Biol. 146: 13-28.
2. BURKE, D. J., D. DAWSON and T. STEARNS, 2000 Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual, pp. 171-181. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
3. CAMPBELL, M. S., G. K. CHAN and T. J. YEN, 2001 Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase. J. Cell Sci. 114: 953-963.
4. CHEN, R. H., A. SHEVCHENKO, M. MANN and A. W. MURRAY, 1998 Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores. J. Cell Biol. 143: 283-295.
5. CHEN, R. H., D. M. BRADY, D. SMITH, A. W. MURRAY and K. G. HARDWICK, 1999 The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins. Mol. Biol. Cell 10: 2607-2618.
6. CHUNG, E., and R. H. CHEN, 2002 Spindle checkpoint requires Mad1-bound and Mad1-free Mad2. Mol. Biol. Cell 13: 1501-1511.
7. COHEN-FIX, O., J. M. PETERS, M. W. KIRSCHNER and D. KOSHLAND, 1996 Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev. 10: 3081-3093.
8. CROTTI, L. B., and M. A. BASRAI, 2004 Functional roles for evolutionarily conserved Spt4p at centromeres and heterochromatin in Saccharomyces cerevisiae. EMBO J. 23: 1804-1814.
9. DOBLES, M., V. LIBERAL, M. L. SCOTT, R. BENEZRA and P. K. SORGER, 2000 Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell 101: 635-645.
10. DRAVIAM, V. M., S. XIE and P. K. SORGER, 2004 Chromosome segregation and genomic stability. Curr. Opin. Genet. Dev. 14: 120-125.
11. FABRE, E., and E. HURT, 1997 Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking. Annu. Rev. Genet. 31: 277-313.
12. GILLETT, E. S., C. W. ESPELIN and P. K. SORGER, 2004 Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast. J. Cell Biol. 164: 535-546.
13. HIETER, P., C. MANN, M. SNYDER and R. W. DAVIS, 1985 Mitotic stability of yeast chromosomes: a colony color assay that measures nondisjunction and chromosome loss. Cell 40: 381-392.
14. HOYT, M. A., L. TOTIS and B. T. ROBERTS, 1991 S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 66: 507-517.
15. IKUI, A. E., K. FURUYA, M. YANAGIDA and T. MATSUMOTO, 2002 Control of localization of a spindle checkpoint protein, Mad2, in fission yeast. J. Cell Sci. 115: 1603-1610.
16. IOUK, T., O. KERSCHER, R. J. SCOTT, M. A. BASRAI and R. W. WOZNIAK, 2002 The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint. J. Cell Biol. 159: 807-819.
17. IWANAGA, Y., T. KASAI, K. KIBLER and K. T. JEANG, 2002 Characterization of regions in hsMAD1 needed for binding hsMAD2. A polymorphic change in an hsMAD1 leucine zipper affects MAD1-MAD2 interaction and spindle checkpoint function. J. Biol. Chem. 277: 31005-31013.
18. KALITSIS, P., E. EARLE, K. J. FOWLER and K. H. CHOO, 2000 Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis. Genes Dev. 14: 2277-2282.
19. KERSCHER, O., P. HIETER, M. WINEY and M. A. BASRAI, 2001 Novel role for a Saccharomyces cerevisiae nucleoporin, Nup170p, in chromosome segregation. Genetics 157: 1543-1553.
20. KERSCHER, O., L. B. CROTTI and M. A. BASRAI, 2003 Recognizing chromosomes in trouble: association of the spindle checkpoint protein Bub3p with altered kinetochores and a unique defective centromere. Mol. Cell. Biol. 23: 6406-6418.
21. KITAGAWA, K., R. ABDULLE, P. K. BANSAL, G. CAGNEY, S. FIELDS et al., 2003 Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint. Mol. Cell 11: 1201-1213.
22. KITAGAWA, R., and A. M. ROSE, 1999 Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans. Nat. Cell Biol. 1: 514-521.
23. LAMB, J. R., W. A. MICHAUD, R. S. SIKORSKI and P. A. HIETER, 1994 Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis. EMBO J. 13: 4321-4328.
24. LEE, M. S., and F. A. SPENCER, 2004 Bipolar orientation of chromosomes in Saccharomyces cerevisiae is monitored by Mad1 and Mad2, but not by Mad3. Proc. Natl. Acad. Sci. USA 101: 10655-10660.
25. LI, R., and A. W. MURRAY, 1991 Feedback control of mitosis in budding yeast. Cell 66: 519-531.
26. LIU, S. T., G. K. CHAN, J. C. HITTLE, G. FUJII, E. LEES et al., 2003 Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores. Mol. Biol. Cell 14: 1638-1651.
27. MARTIN-LLUESMA, S., V. M. STUCKE and E. A. NIGG, 2002 Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science 297: 2267-2270.
28. MUSACCHIO, A., and K. G. HARDWICK, 2002 The spindle checkpoint: structural insights into dynamic signalling. Nat. Rev. Mol. Cell Biol. 3: 731-741.
29. PANGILINAN, F., and F. SPENCER, 1996 Abnormal kinetochore structure activates the spindle assembly checkpoint in budding yeast. Mol. Biol. Cell 7: 1195-1208.
30. SKIBBENS, R. V., and P. HIETER, 1998 Kinetochores and the checkpoint mechanism that monitors for defects in the chromosome segregation machinery. Annu. Rev. Genet. 32: 307-337.
31. SPENCER, F., S. L. GERRING, C. CONNELLY and P. HIETER, 1990 Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124: 237-249.
32. STUKENBERG, T. P., and G. MACARA, 2003 The kintochore NUPtials. Nat. Cell Biol. 5: 945-947.
33. TONG, A. H., M. EVANGELISTA, A. B. PARSONS, H. XU, G. D. BADER et al., 2001 Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294: 2364-2368.
34. TONG, A. H., G. LESAGE, G. D. BADER, H. DING, H. XU et al., 2004 Global mapping of the yeast genetic interaction network. Science 303: 808-813.
35. WARREN, C. D., D. M. BRADY, R. C. JOHNSTON, J. S. HANNA, K. G. HARDWICK et al., 2002 Distinct chromosome segregation roles for spindle checkpoint proteins. Mol. Biol. Cell 13: 3029-3041.
36. WEISS, E., and M. WINEY, 1996 The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint. J. Cell Biol. 132: 111-123.
37. YU, H., 2002 Regulation of APC-Cdc20 by the spindle checkpoint. Curr. Opin. Cell Biol. 14: 706-714.