Abnormal kinetochore structure activates the spindle assembly checkpoint in budding yeast

Molecular Biology of the Cell

Volumn 7, Issue 8, 1996, Pages 1195-1208

  Pangilinan, Faith ^a   Spencer, Forrest ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CENTROMERE; DNA DAMAGE; FUNGAL GENETICS; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; REPRODUCTION; SACCHAROMYCES CEREVISIAE; YEAST;

ANIMALIA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 0029766102     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.7.8.1195     Document Type: Article

References (49)

1. Bernat, R., Borisy, G., Rothfield, N., and Earnshaw, W. (1990). Injection of anti-centromere antibodies in interphase disrupts events required for chromosome movement in mitosis. J. Cell Biol. 111, 1519-1533.
2. Campbell, M.S., and Gorbsky, G.J. (1995). Microinjection of mitotic cells with the 3F3/2 anti-phosphoepitope antibody delays the onset of anaphase. J. Cell Biol. 129, 1195-1204.
3. Carr, A., and Hoekstra, M. (1995). The cellular responses to DNA damage. Trends Cell Biol. 5, 32-40.
4. Coleman, T.R., and Dunphy, W.G. (1994). Cdc2 regulatory factors. Curr. Opin. Cell Biol. 6, 877-882.
5. Doheny, K., Sorger, P., Hyman, A., Tugendriech, S., Spencer, F., and Hieter, P. (1993). Identification of essential components of the S. cerevisiae kinetochore. Cell 73, 1-14.
6. Dutcher, S. (1981). Internuclear transfer of genetic information in kar1-1/KAR1 heterokaryons in Saccharomyces cerevisiae. Mol. Cell. Biol. 1, 245-253.
7. Fankhauser, C., Marks, J., Reymond, A., and Simanis, V. (1993). The S. pombe cdc16 gene is required both for maintenance of p34cdc2 kinase activity and regulation of septum formation: a link between mitosis and cytokinesis? EMBO J. 12, 2697-2704.
8. Goh, P., and Kilmartin, J. (1993). NDC10: a gene involved in chromosome segregation in Saccharomyces cerevisiae. J. Cell Biol. 121, 503-512.
9. Hardwick, K.G., and Murray, A.W. (1995). Mad1p, a phosphoprotein component of the spindle assembly checkpoint of budding yeast. J. Cell Biol. 131, 709-720.
10. Hartwell, L., and Weinert, T. (1989). Checkpoints: controls that ensure the order of cell cycle events. Science 240, 629-634.
11. Hegemann, J.H., and Fleig, U. (1993). The centromere of budding yeast. BioEssays 15, 451-460.
12. Hegemann, J.H., Shero, J.H., Cottarel, G., Philippsen, P., and Hieter, P. (1988). Mutational analysis of centromere DNA from chromosome VI of Saccharomyces cerevisiae. Mol. Cell. Biol. 8, 2523-2535.
13. Hieter, P., Mann, C., Snyder, M., and Davis, R. (1985). Mitotic stability of yeast chromosomes: a colony color assay that measures nondisjunction and chromosome loss. Cell 40, 381-392.
14. Hoyt, A., He, L., Loo, K.K., and Saunders, W. (1992). Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly. J. Cell Biol. 118, 109-120.
15. Hoyt, A., Totis, L., and Roberts, T. (1991). S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 66, 507-517.
16. Huffaker, T.C., Thomas, J.H., and Botstein, D. (1988). Diverse effects of beta-tubulin mutations on microtubule formation and function. J. Cell Biol. 106, 1997-2010.
17. Hugerat, Y., Spencer, F., Zenvirth, D., and Simchen, G. (1994). A versatile method for efficient YAC transfer between any two strains. Genomics 22, 108-117.
18. Hutter, K.J., and Eipel, H.E. (1978). Antonie von Leeuwenhoek. Microbiol. Ser. 44, 269-282.
19. Jones, J.S., and Prakash, L. (1990). Yeast Saccharomyces cerevisiae selectable markers in pUC18 polylinkers. Yeast 6, 363-366.
20. Li, R., Havel, C., Watson, J., and Murray, A. (1994). The mitotic feedback control gene MAD2 encodes the alpha subunit of a phrenyltransferase: correction. Nature 371, 438.
21. Li, R., and Murray, A. (1991). Feedback control of mitosis in budding yeast. Cell 66, 519-531.
22. Li, X., and Nicklas, R.B. (1995). Mitotic forces control a cell cycle checkpoint. Nature 373, 630-632.
23. Lydall, D., and Weinert, T. (1995). Yeast checkpoint genes in DNA damage processing - implications for repair and arrest. Science 270, 1488-1491.
24. McIntosh, J.R. (1991). Structural and mechanical control of mitotic progression. Cold Spring Harbor Symp. Quant. Biol. 56, 613-619.
25. Murray, A., and Kirschner, M.W. (1989). Dominoes and clocks: the union of two views of the cell cycle. Science 240, 614-621.
26. Nicklas, B. (1967). Chromosome micromanipulation: induced reorientation and the experimental control of segregation in meiosis. Chromosoma 21, 17-50.
27. Nicklas, B., Ward, S., and Gorbsky, G. (1995). Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint. J. Cell Biol. 130, 929-939.
28. Nurse, P. (1990). Universal control mechanism regulating onset of M phase. Nature 344, 503-508.
29. Panzeri, L., Landonio, L., Sotz, A., and Philippsen, P. (1985). Role of conserved sequence elements in yeast centromere DNA. EMBO J. 4, 1867-1874.
30. Rieder, C., Schultz, A., Cole, R., and Sluder, G. (1994). Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. J. Cell Biol. 127, 1301-1310.
31. Roberts, T., Farr, K., and Hoyt, A. (1994). The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase. Mol. Cell. Biol. 14, 8282-8291.
32. Roof, D.M., Meluh, P., and Rose, M.D. (1991). Multiple kinesin-related proteins in yeast mitosis. Cold Spring Harbor Symp. Quant. Biol. 56, 693-703.
33. Roof, D.M., Meluh, P., and Rose, M.D. (1992). Kinesin-related proteins required for assembly of the mitotic spindle. J. Cell Biol. 118, 95-108.
34. Rose, M., Winston, F., and Hieter, P. (1990). Methods in Yeast Genetics: A Laboratory Course Manual, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
35. Rothstein, R. (1991). Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Methods Enzymol. 194, 281-301.
36. Schatz, P.J., Solomon, F., and Botstein, D. (1988). Isolation and characterization of conditional-lethal mutations in the TUB1 alpha-tubulin gene of the yeast Saccharomyces cerevisiae. Genetics 120, 681-695.
37. Shero, J., Koval, M., Spencer, F., Palmer, R., Hieter, P., and Koshland, D. (1991). Analysis of chromosome segregation in Saccharomyces cerevisiae. Methods Enzymol. 194, 749-773.
38. Sikorski, R., and Hieter, P. (1989). A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27.
39. Simerly, C., Balczon, R., Brinkley, B., and Schatten, G. (1990). Microinjected kinetochore antibodies interfere with chromosome movement in meiotic and mitotic mouse oocytes. J. Cell Biol. 111, 1491-1504.
40. Spencer, F., Gerring, S., Connelly, C., and Hieter, P. (1990). Chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124, 237-249.
41. Spencer, F., Hugerat, Y., Simchen, G., Hurko, O., Connelly, C., and Hieter, P. (1994). Yeast kar1 mutants provide an effective method for YAC transfer to new hosts. Genomics 22, 118-126.
42. Strunnikov, A., Kingsbury, J., and Koshland, D. (1995). CEP3 encodes a centromere protein of Saccharomyces cerevisiae. J. Cell Biol. 128, 749-760.
43. Tomkiel, J., Cooke, C., Saitoh, H., Bernat, R., and Earnshaw, W. (1994). CENP-C is required for maintaining proper kinetochore size and for a timely transition to anaphase. J. Cell Biol. 125, 531-545.
44. Wang, Y., and Burke, D. (1995). Checkpoint genes required to delay cell division in response to nocodazole respond to impaired kinetochore function in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 15, 6838-6844.
45. Weinert, T., and Hartwell, L. (1988). The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241, 317-322.
46. Weinert, T., and Hartwell, L. (1993). Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint. Genetics 134, 63-80.
47. Weiss, E., and Winey, M. (1996). The Saccharomyces cerevisiae spindle-pole body duplication gene MPS1 is part of a mitotic checkpoint. J. Cell Biol. 132, 111-123.
48. Wells, W., and Murray, A. (1996). Aberrantly segregating centromeres activate the spindle assembly checkpoint in budding yeast. J. Cell Biol. 133, 75-84.
49. Zirkle, R. (1970). UV-microbeam irradiation of newt-cell cytoplasm: spindle destruction, false anaphase, and delay of true anaphase. Radiat. Res. 41, 516-537.