-
1
-
-
22044433952
-
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Chromium
-
IARC, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Chromium, Nickel and Welding, 1990, 49, p. 677-691.
-
(1990)
Nickel and Welding
, vol.49
, pp. 677-691
-
-
-
4
-
-
0033835509
-
Inorganic dust pneumonias: The metal-related parenchymal disorders
-
Kelleher, P.; Pacheco, K.; Newman, L. S.: Inorganic dust pneumonias: the metal-related parenchymal disorders. Environ Health Perspect, 2000,108 Suppl 4, 685-96.
-
(2000)
Environ. Health Perspect.
, vol.108
, Issue.4 SUPPL.
, pp. 685-696
-
-
Kelleher, P.1
Pacheco, K.2
Newman, L.S.3
-
5
-
-
0031028158
-
Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors
-
Huang, L. E.; Ho, V.; Arany, Z.; Krainc, D.; Galson, D.; Tendler, D.; Livingston, D. M.; Bunn, H. F.: Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors. Kidney Int, 1997, 51(2), 548-52.
-
(1997)
Kidney Int.
, vol.51
, Issue.2
, pp. 548-552
-
-
Huang, L.E.1
Ho, V.2
Arany, Z.3
Krainc, D.4
Galson, D.5
Tendler, D.6
Livingston, D.M.7
Bunn, H.F.8
-
6
-
-
0036805777
-
The role of hypoxia-inducible signaling pathway in nickel carcinogenesis
-
Salnikow, K.; Davidson, T.; Costa, M.: The role of hypoxia-inducible signaling pathway in nickel carcinogenesis. Environ Health Perspect, 2002, 770 Suppl 5, 831-4.
-
(2002)
Environ. Health Perspect.
, vol.770
, Issue.5 SUPPL.
, pp. 831-834
-
-
Salnikow, K.1
Davidson, T.2
Costa, M.3
-
7
-
-
0024273450
-
Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
-
Goldberg, M. A.; Dunning, S. P.; Bunn, H. F.: Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science, 1988, 242(4884), 1412-5.
-
(1988)
Science
, vol.242
, Issue.4884
, pp. 1412-1415
-
-
Goldberg, M.A.1
Dunning, S.P.2
Bunn, H.F.3
-
8
-
-
18544386401
-
Hypoxia-inducible factor (HEF) asparagines hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
-
Hewitson, K. S.; McNeill, L. A.; Riordan, M. V.; Tian, Y. M.; Bullock, A. N.; Welford, R. W.; Elkins, J. M.; Oldham, N. J.; Bhattacharya, S.; Gleadle, J. M.; Ratcliffe, P. J.; Pugh, C. W.; Schofield, C. J.: Hypoxia-inducible factor (HEF) asparagines hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J. Biol Chem, 2002, 277(29), 26351-5.
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.29
, pp. 26351-26355
-
-
Hewitson, K.S.1
McNeill, L.A.2
Riordan, M.V.3
Tian, Y.M.4
Bullock, A.N.5
Welford, R.W.6
Elkins, J.M.7
Oldham, N.J.8
Bhattacharya, S.9
Gleadle, J.M.10
Ratcliffe, P.J.11
Pugh, C.W.12
Schofield, C.J.13
-
9
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein, A. C; Gleadle, J. M.; McNeill, L. A.; Hewitson, K. S.; Oliourke, J.; Mole, D. R.; Mukherji, M.; Metzen, E.; Wilson, M. I.; Dhanda, A.; Tian, Y. M.; Masson, N.; Hamilton, D. L.; Jaakkola, P.; Barstead, R.; Hodgkin, J.; Maxwell, P. H.; Pugh, C. W.; Schofield, C. J.; Ratcliffe, P. J.: C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell, 2001, 107(1), 43-54.
-
(2001)
Cell
, vol.107
, Issue.1
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
Oliourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
Tian, Y.M.11
Masson, N.12
Hamilton, D.L.13
Jaakkola, P.14
Barstead, R.15
Hodgkin, J.16
Maxwell, P.H.17
Pugh, C.W.18
Schofield, C.J.19
Ratcliffe, P.J.20
more..
-
10
-
-
0034006016
-
HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
-
Semenza, G.L., HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol, 2000, 88(4), 1474-80.
-
(2000)
J. Appl. Physiol.
, vol.88
, Issue.4
, pp. 1474-1480
-
-
Semenza, G.L.1
-
11
-
-
15444342958
-
2 homeostasis by hypoxia-inducible factor 1 alpha
-
2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev, 1998, 12(2), 149-62.
-
(1998)
Genes Dev.
, vol.12
, Issue.2
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
Wenger, R.H.6
Gassmann, M.7
Gearhart, J.D.8
Lawler, A.M.9
Yu, A.Y.10
Semenza, G.L.11
-
12
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang, G. L.; Jiang, B. H.; Rue, E. A.; Semenza, G. L.: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA, 1995, 92(12), 5510-4.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, Issue.12
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
13
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza, G. L.: Targeting HIF-1 for cancer therapy. Nat Rev Cancer, 2003, 3(10), 721-32.
-
(2003)
Nat. Rev. Cancer
, vol.3
, Issue.10
, pp. 721-732
-
-
Semenza, G.L.1
-
14
-
-
0036380377
-
A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology
-
Acker, T.; Plate, K. H.: A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology. J Mol Med,, 2000, 80(9), 562-75.
-
(2000)
J. Mol. Med.
, vol.80
, Issue.9
, pp. 562-575
-
-
Acker, T.1
Plate, K.H.2
-
15
-
-
0035917313
-
2 sensing
-
2 sensing. Science, 2001, 292(5516), 464-8.
-
(2001)
Science
, vol.292
, Issue.5516
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
16
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola, P.; Mole, D. R.; Tian, Y. M.; Wilson, M. I.; Gielbert, J.; Gaskell, S. J.; Kriegsheim, A.; Hebestreit, H. F.; Mukherji, M.; Schofield, C. J.; Maxwell, P. H.; Pugh, C. W.; Ratcliffe, P. J.: Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science, 2001, 292(5516), 468-72.
-
(2001)
Science
, vol.292
, Issue.5516
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
17
-
-
0035834409
-
A conserved family of prolyM-hydroxylases that modify HIF
-
Bruick, R. K.; McKnight, S. L.: A conserved family of prolyM-hydroxylases that modify HIF. Science, 2001, 294(5545), 1337-10.
-
(2001)
Science
, vol.294
, Issue.5545
, pp. 1337-1410
-
-
Bruick, R.K.1
McKnight, S.L.2
-
18
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
-
Lando, D.; Peet, D. J.; Whelan, D. A.; Gorman, J. J.; Whitelaw, M. L.: Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science, 2002, 295(5556), 858-61.
-
(2002)
Science
, vol.295
, Issue.5556
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
19
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando, D.; Peet, D. J.; Gorman, J. J.; Whelan, D. A.; Whitelaw, M. L.; Bruick, R. K.: FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev, 2002, 16(12), 1466-71.
-
(2002)
Genes Dev.
, vol.16
, Issue.12
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
20
-
-
18744375998
-
Regulation and destabilization of HLF-lalpha by ARD1-mediated acetylation
-
Jeong, J. W.; Bae, M. K.; Ann, M. Y.; Kim, S. H.; Sohn, T. K.; Bae, M. H.; Yoo, M. A.; Song, E. J.; Lee, K. J.; Kim, K. W.: Regulation and destabilization of HLF-lalpha by ARD1-mediated acetylation. Cell, 2002, 111(5), 709-20.
-
(2002)
Cell
, vol.111
, Issue.5
, pp. 709-720
-
-
Jeong, J.W.1
Bae, M.K.2
Ann, M.Y.3
Kim, S.H.4
Sohn, T.K.5
Bae, M.H.6
Yoo, M.A.7
Song, E.J.8
Lee, K.J.9
Kim, K.W.10
-
21
-
-
0032725554
-
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1 alpha (HIF-1 alpha) and enhance the transcriptional activity of HIF-1
-
Richard, D. E.; Berra, E.; Gothie, E.; Roux, D.; Pouyssegur, J.: p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1 alpha (HIF-1 alpha) and enhance the transcriptional activity of HIF-1. J. Biol Chem, 1999, 274(46), 32631-7.
-
(1999)
J. Biol. Chem.
, vol.274
, Issue.46
, pp. 32631-32637
-
-
Richard, D.E.1
Berra, E.2
Gothie, E.3
Roux, D.4
Pouyssegur, J.5
-
22
-
-
0030961006
-
Hypoxia-inducible factor lalpha (HIF-lalpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
-
Salceda, S.; Caro, J.: Hypoxia-inducible factor lalpha (HIF-lalpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem, 1997, 272(36), 22642-7.
-
(1997)
J. Biol. Chem.
, vol.272
, Issue.36
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
23
-
-
0032493368
-
Regulation of hypoxia-inducible factor lalpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
-
Huang, L. E.; Gu, J.; Schau, M.; Bunn, H. F.: Regulation of hypoxia-inducible factor lalpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci. USA, 1998, 95(14), 7987-92.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, Issue.14
, pp. 7987-7992
-
-
Huang, L.E.1
Gu, J.2
Schau, M.3
Bunn, H.F.4
-
24
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell, P. H.; Wiesener, M. S.; Chang, G. W.; Clifford, S. C; Vaux, E. C; Cockman, M. E.; Wykoff, C. C; Pugh, C. W.; Maher, E. R.; Ratcliffe, P. J.: The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature, 1999, 399(6733), 271-5.
-
(1999)
Nature
, vol.399
, Issue.6733
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
25
-
-
0034904751
-
Hypoxia-inducible factor-alpha (HIF-1 alpha) escapes O2-driven proteasomal degradation irrespective of its subcellular localization: Nucleus or cytoplasm
-
2-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm. EMBO Rep, 2001, 2(7), 615-20.
-
(2001)
EMBO Rep.
, vol.2
, Issue.7
, pp. 615-620
-
-
Berra, E.1
Roux, D.2
Richard, D.E.3
Pouyssegur, J.4
-
26
-
-
0029803552
-
An essential role or p300/CBP in the cellular response to hypoxia
-
Arany, Z.; Huang, L. E.; Eckner, R.; Bhattacharya, S.; Jiang, C; Goldberg, M. A.; Bunn, H. F.; Livingston, D. M.: An essential role or p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA, 1996, 93(23), 12969-73.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, Issue.23
, pp. 12969-12973
-
-
Arany, Z.1
Huang, L.E.2
Eckner, R.3
Bhattacharya, S.4
Jiang, C.5
Goldberg, M.A.6
Bunn, H.F.7
Livingston, D.M.8
-
27
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-lalpha and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon, P. C; Hirota, K.; Semenza, G. L.: FIH-1: a novel protein that interacts with HIF-lalpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev, 2001, 15(20), 2675-86.
-
(2001)
Genes Dev.
, vol.15
, Issue.20
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
28
-
-
0033984256
-
Carcinogenic nickel induces genes involved with hypoxic stress
-
Salnikow, K.; Blagosklonny, M. V.; Ryan, H.; Johnson, R.; Costa, M.: Carcinogenic nickel induces genes involved with hypoxic stress. Cancer Res, 2000, 60(1), 38-41.
-
(2000)
Cancer Res.
, vol.60
, Issue.1
, pp. 38-41
-
-
Salnikow, K.1
Blagosklonny, M.V.2
Ryan, H.3
Johnson, R.4
Costa, M.5
-
29
-
-
0032877460
-
Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors
-
Salnikow, K.; An, W. G.; Melillo, G.; Blagosklonny, M. V.; Costa, M.: Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors. Carcinogenesis, 1999, 20(9), 1819-23.
-
(1999)
Carcinogenesis
, vol.20
, Issue.9
, pp. 1819-1823
-
-
Salnikow, K.1
An, W.G.2
Melillo, G.3
Blagosklonny, M.V.4
Costa, M.5
-
30
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
Wang, G. L.; Semenza, G. L.: Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem., 1995, 270(3), 1230-7.
-
(1995)
J. Biol. Chem.
, vol.270
, Issue.3
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
31
-
-
4644260710
-
Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress
-
Salnikow, K.; Donald, S. P.; Bruick, R. K.; Zhitkovich, A.; Phang, J. M.; Kasprzak, K. S.: Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. J Biol Chem, 2004.
-
(2004)
J. Biol. Chem.
-
-
Salnikow, K.1
Donald, S.P.2
Bruick, R.K.3
Zhitkovich, A.4
Phang, J.M.5
Kasprzak, K.S.6
|