The role of suppressors of cytokine signalling in thymopoiesis and T cell activation

International Journal of Biochemistry and Cell Biology

Volumn 37, Issue 9, 2005, Pages 1774-1786

  Fletcher, Joel ^a   Starr, Robyn ^a  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Immune regulation; SOCS proteins; T cell activation; Thymopoiesis

Indexed keywords

JANUS KINASE; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3;

CELL MATURATION; CELL PROLIFERATION; CELLULAR IMMUNITY; HOMEOSTASIS; IMMUNOREGULATION; LYMPHOCYTE ACTIVATION; NEGATIVE FEEDBACK; NONHUMAN; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

ANIMALS; CYTOKINES; HUMANS; LYMPHOCYTE ACTIVATION; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSCRIPTION FACTORS;

EID: 21844432138     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2005.04.005     Document Type: Review

References (82)

1. K. Akashi, M. Kondo, U. von Freeden-Jeffry, R. Murray, and I.L. Weissman Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice Cell 89 1997 1033 1041
2. W.S. Alexander, and D.J. Hilton The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response Annual Reviews of Immunology 22 2004 503 529
3. W.S. Alexander, R. Starr, J.E. Fenner, C.L. Scott, E. Handman, and N.S. Sprigg SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine Cell 98 1999 597 608
4. L. Alexopoulou, A.C. Holt, R. Medzhitov, and R.A. Flavell Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3 Nature 413 2001 732 738
5. M.J. Aman, T.S. Migone, A. Sasaki, D.P. Ascherman, M. Zhu, and E. Soldaini CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling Journal of Biological Chemistry 274 1999 30266 30272
6. G. Anderson, and E.J. Jenkinson Lymphostromal interactions in thymic development and function Nature Reviews in Immunology 1 2001 31 40
7. A.M. Baird, R.M. Gerstein, and L.J. Berg The role of cytokine receptor signaling in lymphocyte development Current Opinion in Immunology 11 1999 157 166
8. A. Banerjee, A.S. Banks, M.C. Nawijn, X.P. Chen, and P.B. Rothman Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp Journal of Immunology 168 2002 4277 4281
9. J.G. Baseta, and O. Stutman TNF regulates thymocyte production by apoptosis and proliferation of the triple negative (CD3-CD4-CD8-) subset Journal of Immunology 165 2000 5621 5630
10. S.P. Berzins, R.L. Boyd, and J.F. Miller The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool Journal of Experimental Medicine 187 1998 1839 1848
11. P.A. Bretscher A two-step, two-signal model for the primary activation of precursor helper T cells Proceedings of the National Academy of Sciences of the United States of America 96 1999 185 190
12. M. Brysha, J.G. Zhang, P. Bertolino, J.E. Corbin, W.S. Alexander, and N.A. Nicola Suppressor of cytokine signaling-1 attenuates the duration of interferon gamma signal transduction in vitro and in vivo Journal of Biological Chemistry 276 2001 22086 22089
13. F.M. Burnet The immunological significance of the thymus: An extension of the clonal selection theory of immunity Australasian Annals of Medicine 11 1962 79 91
14. M.M. Chong, A.L. Cornish, R. Darwiche, E.G. Stanley, J.F. Purton, and D.I. Godfrey Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation Immunity 18 2003 475 487
15. P. Chrobak Control of T cell responses, tolerance and autoimmunity by regulatory T cells: Current concepts Acta Medica (Hradec Kralove) 46 2003 131 137
16. A.L. Cornish, M.M. Chong, G.M. Davey, R. Darwiche, N.A. Nicola, and D.J. Hilton Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells Journal of Biological Chemistry 278 2003 22755 22761
17. A.L. Cornish, G.M. Davey, D. Metcalf, J.F. Purton, J.E. Corbin, and C.J. Greenhalgh Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis Journal of Immunology 170 2003 878 886
18. B.A. Croker, D.L. Krebs, J.G. Zhang, S. Wormald, T.A. Willson, and E.G. Stanley SOCS3 negatively regulates IL-6 signaling in vivo Nature Immunology 4 2003 540 545
19. J.E. Darnell Jr. STATs and gene regulation Science 277 1997 1630 1635
20. P. De Sepulveda, K. Okkenhaug, J.L. Rose, R.G. Hawley, P. Dubreuil, and R. Rottapel Socs1 binds to multiple signalling proteins and suppresses Steel factor-dependent proliferation EMBO Journal 18 1999 904 915
21. E. Donskoy, and I. Goldschneider Thymocytopoiesis is maintained by blood-borne precursors throughout postnatal life. A study in parabiotic mice Journal of Immunology 148 1992 1604 1612
22. T.A. Endo, M. Masuhara, M. Yokouchi, R. Suzuki, H. Sakamoto, and K. Mitsui A new protein containing an SH2 domain that inhibits JAK kinases Nature 387 1997 921 924
23. G.J. Freeman, F. Borriello, R.J. Hodes, H. Reiser, J.G. Gribben, and J.W. Ng Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production Journal of Experimental Medicine 178 1993 2185 2192
24. G.J. Freeman, G.S. Gray, C.D. Gimmi, D.B. Lombard, L.J. Zhou, and M. White Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7 Journal of Experimental Medicine 174 1991 625 631
25. M. Fujimoto, T. Naka, R. Nakagawa, Y. Kawazoe, Y. Morita, and A. Tateishi Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice Journal of Immunology 165 2000 1799 1806
26. T. Fukao, M. Tanabe, Y. Terauchi, T. Ota, S. Matsuda, and T. Asano PI3K-mediated negative feedback regulation of IL-12 production in DCs Nature Immunology 3 2002 875 881
27. D.I. Godfrey, J. Kennedy, T. Suda, and A. Zlotnik A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8-triple-negative adult mouse thymocytes defined by CD44 and CD25 expression Journal of Immunology 150 1993 4244 4252
28. D.I. Godfrey, A. Zlotnik, and T. Suda Phenotypic and functional characterization of c-kit expression during intrathymic T cell development Journal of Immunology 149 1992 2281 2285
29. A.W. Goldrath, L.Y. Bogatzki, and M.J. Bevan Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation Journal of Experimental Medicine 192 2000 557 564
30. S.J. Haque, P. Harbor, M. Tabrizi, T. Yi, and B.R. Williams Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction Journal of Biological Chemistry 273 1998 33893 33896
31. F.A. Harding, J.G. McArthur, J.A. Gross, D.H. Raulet, and J.P. Allison CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones Nature 356 1992 607 609
32. H. Hemmi, O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, and H. Sanjo A toll-like receptor recognizes bacterial DNA Nature 408 2000 740 745
33. D.J. Hilton, R.T. Richardson, W.S. Alexander, E.M. Viney, T.A. Willson, and N.S. Sprigg Twenty proteins containing a C-terminal SOCS box form five structural classes Proceedings of the National Academy of Sciences of the United States of America 95 1998 114 119
34. K.A. Hogquist Signal strength in thymic selection and lineage commitment Current Opinion in Immunology 13 2001 225 231
35. S. Hori, T. Takahashi, and S. Sakaguchi Control of autoimmunity by naturally arising regulatory CD4+ T cells Advances in Immunology 81 2003 331 371
36. S. Ilangumaran, S. Ramanathan, J. La Rose, P. Poussier, and R. Rottapel Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44 high memory T lymphocytes Journal of Immunology 171 2003 2435 2445
37. S. Ilangumaran, S. Ramanathan, T. Ning, J. La Rose, B. Reinhart, and P. Poussier Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes Blood 102 2003 4115 4122
38. C.A. Janeway Jr. The immune system evolved to discriminate infectious nonself from noninfectious self Immunology Today 13 1992 11 16
39. M.K. Jenkins, C.A. Chen, G. Jung, D.L. Mueller, and R.H. Schwartz Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody Journal of Immunology 144 1990 16 22
40. T. Kamura, S. Sato, D. Haque, L. Liu, W.G. Kaelin Jr., and R.C. Conaway The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families Genes and Development 12 1998 3872 3881
41. B.T. Kile, B.A. Schulman, W.S. Alexander, N.A. Nicola, H.M. Martin, and D.J. Hilton The SOCS box: A tale of destruction and degradation Trends in Biochemical Sciences 27 2002 235 241
42. M. Kondo, K. Akashi, J. Domen, K. Sugamura, and I.L. Weissman Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice Immunity 7 1997 155 162
43. A. Kupfer, G. Dennert, and S.J. Singer Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets Proceedings of the National Academy of Sciences of the United States of America 80 1983 7224 7228
44. W.C. Lin, and S. Desiderio V(D)J recombination and the cell cycle Immunology Today 16 1995 279 289
45. E.F. Lind, S.E. Prockop, H.E. Porritt, and H.T. Petrie Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development Journal of Experimental Medicine 194 2001 127 134
46. J.A. Losman, X.P. Chen, D. Hilton, and P. Rothman Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction Journal of Immunology 162 1999 3770 3774
47. J.C. Marine, D.J. Topham, C. McKay, D. Wang, E. Parganas, and D. Stravopodis SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality Cell 98 1999 609 616
48. T. Matsuda, T. Yamamoto, H. Kishi, A. Yoshimura, and A. Muraguchi SOCS-1 can suppress CD3zeta- and Syk-mediated NF-AT activation in a non-lymphoid cell line FEBS Letters 472 2000 235 240
49. A. Matsumoto, M. Masuhara, K. Mitsui, M. Yokouchi, M. Ohtsubo, and H. Misawa CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation Blood 89 1997 3148 3154
50. A. Matsumoto, Y.I. Seki, R. Watanabe, K. Hayashi, J.A. Johnston, and Y. Harada A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production Journal of Experimental Medicine 197 2003 425 436
51. E. Mertsching, C. Burdet, and R. Ceredig IL-7 transgenic mice: Analysis of the role of IL-7 in the differentiation of thymocytes in vivo and in vitro International Immunology 7 1995 401 414
52. Metcalf, D., Mifsud, S., Di Rago, L., Nicola, N. A., Hilton, D. J., & Alexander, W. S. (2002). Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Proceedings of the National Academy of Sciences of the United States of America, 99, 943-948.
53. S. Miyake, M.L. Lupher Jr., B. Druker, and H. Band The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha Proceedings of the National Academy of Sciences of the United States of America 95 1998 7927 7932
54. T. Naka, M. Narazaki, M. Hirata, T. Matsumoto, S. Minamoto, and A. Aono Structure and function of a new STAT-induced STAT inhibitor Nature 387 1997 924 929
55. M. Narazaki, M. Fujimoto, T. Matsumoto, Y. Morita, H. Saito, and T. Kajita Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling Proceedings of the National Academy of Sciences of the United States of America 95 1998 13130 13134
56. S.E. Nicholson, D. De Souza, L.J. Fabri, J. Corbin, T.A. Willson, and J.G. Zhang Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130 Proceedings of the National Academy of Sciences of the United States of America 97 2000 6493 6498
57. S.E. Nicholson, T.A. Willson, A. Farley, R. Starr, J.G. Zhang, and M. Baca Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction EMBO Journal 18 1999 375 385
58. N.A. Nicola Guidebook to cytokines and their receptors 1994 Oxford University Press Oxford
59. G.J. Nossal, and B.L. Pike Clonal anergy: Persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen Proceedings of the National Academy of Sciences of the United States of America 77 1980 1602 1606
60. K. Ohya, S. Kajigaya, Y. Yamashita, A. Miyazato, K. Hatake, and Y. Miura SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase Journal of Biological Chemistry 272 1997 27178 27182
61. J.J. Peschon, P.J. Morrissey, K.H. Grabstein, F.J. Ramsdell, E. Maraskovsky, and B.C. Gliniak Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice Journal of Experimental Medicine 180 1994 1955 1960
62. A. Poltorak, X. He, I. Smirnova, M.Y. Liu, C. Van Huffel, and X. Du Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene Science 282 1998 2085 2088
63. A. Poltorak, I. Smirnova, X. He, M.Y. Liu, C. Van Huffel, and O. McNally Genetic and physical mapping of the Lps locus: Identification of the toll-4 receptor as a candidate gene in the critical region Blood Cells Molecular Disease 24 1998 340 355
64. Y. Qing, A.P. Costa-Pereira, D. Watling, and G.R. Stark Role of tyrosine 441 of interferon-gamma receptor subunit 1 in SOCS-1-mediated attenuation of STAT1 activation Journal of Biological Chemistry 280 2005 1849 1853
65. H.R. Rodewald, K. Kretzschmar, W. Swat, and S. Takeda Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo Immunity 3 1995 313 319
66. A. Sasaki, H. Yasukawa, A. Suzuki, S. Kamizono, T. Syoda, and I. Kinjyo Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain Genes to Cells 4 1999 339 351
67. R.H. Schwartz Models of T cell anergy: Is there a common molecular mechanism? Journal of Experimental Medicine 184 1996 1 8
68. K. Shortman, M. Egerton, G.J. Spangrude, and R. Scollay The generation and fate of thymocytes Seminars in Immunology 2 1990 3 12
69. B. Sporri, P.E. Kovanen, A. Sasaki, A. Yoshimura, and W.J. Leonard JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling Blood 97 2001 221 226
70. T.K. Starr, S.C. Jameson, and K.A. Hogquist Positive and negative selection of T cells Annual Reviews of Immunology 21 2003 139 176
71. R. Starr, D. Metcalf, A.G. Elefanty, M. Brysha, T.A. Willson, and N.A. Nicola Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signalling-1 Proceedings of the National Academy of Sciences of the United States of America 95 1998 14395 14399
72. R. Starr, T.A. Willson, E.M. Viney, L.J. Murray, J.R. Rayner, and B.J. Jenkins A family of cytokine-inducible inhibitors of signalling Nature 387 1997 917 921
73. S. Trop, P. De Sepulveda, J.C. Zuniga-Pflucker, and R. Rottapel Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes Blood 97 2001 2269 2277
74. U. von Freeden-Jeffry, P. Vieira, L.A. Lucian, T. McNeil, S.E. Burdach, and R. Murray Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine Journal of Experimental Medicine 181 1995 1519 1526
75. L. Whitaker, and A.M. Renton On the plausibility of the clonal expansion theory of the immune system in terms of the combinatorial possibilities of amino-acids in antigen and self-tolerance Journal of Theoretical Biology 164 1993 531 536
76. H. Yasukawa, H. Misawa, H. Sakamoto, M. Masuhara, A. Sasaki, and T. Wakioka The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop EMBO Journal 18 1999 1309 1320
77. H. Yasukawa, A. Sasaki, and A. Yoshimura Negative regulation of cytokine signaling pathways Annual Reviews of Immunology 18 2000 143 164
78. A. Yoshimura, T. Ohkubo, T. Kiguchi, N.A. Jenkins, D.J. Gilbert, and N.G. Copeland A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors EMBO Journal 14 1995 2816 2826
79. C.R. Yu, R.M. Mahdi, S. Ebong, B.P. Vistica, I. Gery, and C.E. Egwuagu Suppressor of cytokine signaling 3 regulates proliferation and activation of T-helper cells Journal of Biological Chemistry 278 2003 29752 29759
80. J.G. Zhang, A. Farley, S.E. Nicholson, T.A. Willson, L.M. Zugaro, and R.J. Simpson The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation Proceedings of the National Academy of Sciences of the United States of America 96 1999 2071 2076
81. J.G. Zhang, D. Metcalf, S. Rakar, M. Asimakis, C.J. Greenhalgh, and T.A. Willson The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo Proceedings of the National Academy of Sciences of the United States of America 98 2001 13262 13265
82. A. Zlotnik, D.I. Godfrey, M. Fischer, and T. Suda Cytokine production by mature and immature CD4-CD8-T cells. Alpha beta-T cell receptor+ CD4-CD8-T cells produce IL-4 Journal of Immunology 149 1992 1211 1215