TNF regulates thymocyte production by apoptosis and proliferation of the triple negative (CD3-CD4-CD8-) subset

Journal of Immunology

Volumn 165, Issue 10, 2000, Pages 5621-5630

  Baseta, J G ^a   Stutman, O ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 7; MONOCLONAL ANTIBODY; PROTEIN P55; PROTEIN P75; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HOMEOSTASIS; HYPERTROPHY; IMMUNE RESPONSE; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE;

EID: 0034669967     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.10.5621     Document Type: Article

References (72)

1. Tumor necrosis factor (TNF)
2. Biology of disease: Tumor necrosis factor and interleukin 1: Cytokines with multiple overlapping biological activities
3. The biology of cachectin/TNF - A primary mediator of the host response
4. Tumor necrosis factor: Characterization at the molecular, cellular and in vivo level
5. The pathophysiology of tumor necrosis factors
6. Cell death induction by receptors of the TNF family: Toward a molecular understanding
7. Death-inducing functions of ligands of the tumor necrosis factor family: A Sanhedrin verdict
8. Constitutive synthesis of tumor necrosis factor in the thymus
9. T-cell apoptosis detected in situ during positive and negative selection in the thymus
10. Tumor necrosis factor α/cachectin is a growth factor for thymocytes: Synergistic interactions with other cytokines
11. Both interleukin 1 and tumor necrosis factor enhance thymocyte proliferation
12. Synergism of interleukin 7 with thymocyte growth factors interleukin 2, interleukin 6 and tumor necrosis factor α in the induction of thymocyte proliferation
13. - double-negative thymocytes
14. Requirement for TNF-α and IL-1-α in fetal thymocyte commitment and differentiation
15. Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation
16. - thymocytes
17. - triple-negative adult mouse thymocytes defined by CD44 and CD25 expression
18. Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
19. T cell receptor gene recombination patterns and mechanisms: Cell death, rescue, and T cell production
20. RAG-1-deficient mice have no mature B and T lymphocytes
21. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation
22. Characterization of tumor necrosis factor-deficient mice
23. Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: Identification of a novel in vivo role for p75
24. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide and flow cytometry
25. Cell cycle dependent TNF apoptosis
26. The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents
27. Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation
28. + thymocytes by the anti-Fas antibody
29. Cellular aspects of early T-cell development
30. T-cell lineage commitment and cytokine response of thymic progenitors
31. Control points in early T-cell development
32. A murine early developmental sequence is marked by transient expression of the interleukin 2 receptor
33. Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific
34. Membrane tumor necrosis factor (TNF) induced cooperative signaling of TNFR60 and TNFR80 favours induction of cell death rather than virus production in HIV-infected T cells
35. Two tumor necrosis factor receptors: Structure and function
36. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
37. Impaired survival and proliferation in IL-7 receptor deficient peripheral T cells
38. The role of IL-7 in thymic and extrathymic development of TCRγδ cells
39. Early preferential stimulation of γδ T cells by TNF-α
40. Suicide by order: Some open questions about the cell killing activities of the TNF ligand and receptor families
41. Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-κB activation and c-Jun kinase activation
42. A potential mechanism of 'cross talk' between p55 tumor necrosis factor and Fas/APO1: Proteins binding to death domains of the two receptors also bind to each other
43. Tumor necrosis factorα (TNFα)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type
44. Establishment of the role of IL-6 and TNF receptor 1 using gene knock out mice
45. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Lysteria monocytogenes
46. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxin shock, yet succumb to L. monocytogenes infection
47. Decreased sensitivity to tumor necrosis factor but normal T cell development in TNF receptor-2-deficient mice
48. Antiviral activity of tumor necrosis factor (TNF) is mediated via p55 and p75 TNF receptors
49. Crucial role of 55-kilodalton TNF receptor in TNF-induced adhesion molecule expression and leukocyte organ infiltration
50. Depressed Langerhans cell migration and reduced contact hypersensitivity response in mice lacking TNF receptor p75
51. Susceptibility to Pneumocystis carinii in mice is dependent on simultaneous deletion of IFN-γ and type 1 and 2 TNF receptor genes
52. Crucial role of TNF receptor type 1 (p55) but not of TNF receptor type 2 (p75) in murine toxoplasmosis
53. The two different receptors for tumor necrosis factor mediate distinct cellular responses
54. The TNF receptor 1 associated protein TRADD signals cell death and NF-κB activation
55. The p70 tumor necrosis factor mediates cytotoxicity
56. Ligand passing: The 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor
57. Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration
58. Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80: Requirement of the TNF receptor-associated factor 2 binding site
59. Cooperation of both TNF receptors in inducing apoptosis: Involvement of the TNF receptor-associated factor binding domain of the TNF receptor p75
60. TNFR80-dependent enhancement of TNFR60-induced cell death is mediated by TNFR-associated factor 2 and is specific for TNR60
61. Induction of cell death by tumor necrosis factor (TNF) receptor 2, CD40 and CD30: A role for TNF-R1 activation by endogenous membrane-anchored TNF
62. The trophic action of IL-7 on pro-T cells: Inhibition of apoptosis of pro-T1, -T2 and -T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways
63. TNF-α bidirectionally modulates the viability of primitive murine hematopoietic progenitor cells in vitro
64. Tumor necrosis factor-α mediates both apoptotic cell death and cell proliferation in a human hematopoietic cell line dependent on mitotic activity and receptor subtype expression
65. TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1
66. Cellular aspects of early T-cell development
67. Control points in early T-cell development
68. T cell receptor (TCR)-β gene recombination: Dissociation from cell cycle regulation and developmental progression during T cell ontogeny
69. TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection
70. Cytotoxic effects of TNF and lymphotoxin on T lymphoblasts
71. Induction of apoptosis in mature T cells by tumour necrosis factor
72. Greatly accelerated lymphoadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor 1