A New Class of Bacteria RNA Polymerase Inhibitor Affects Nucleotide Addition

Science

Volumn 302, Issue 5645, 2003, Pages 650-654

  Artsimovitch, Irina ^a,c   Chu, Clement ^b   Lynch, A Simon ^b   Landick, Robert ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b Cumbre Inc   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CATALYSIS; CATALYST ACTIVITY; DNA; ENZYME INHIBITION; GENES;

GENE EXPRESSION;

RNA;

BACTERIAL RNA; BACTERIAL RNA POLYMERASE INHIBITOR; CBR 703; RNA POLYMERASE; UNCLASSIFIED DRUG; AMIDINE; BACTERIAL DNA; CARBANILAMIDE DERIVATIVE; CBR 9379; CBR 9393; DNA DIRECTED RNA POLYMERASE; ENZYME INHIBITOR; EXODEOXYRIBONUCLEASE; EXODEOXYRIBONUCLEASE III; HYDROXYLAMINE; NUCLEOTIDE; PIPERAZINE DERIVATIVE; PYRAZOLE DERIVATIVE;

ENZYME; GENE; RNA;

ALLOSTERISM; ALPHA HELIX; ARTICLE; BINDING SITE; CATALYSIS; CRYSTAL STRUCTURE; DNA TRANSPORT; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; GENE EXPRESSION; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PYROPHOSPHOROLYSIS; RNA TRANSPORT; ANTIBIOTIC RESISTANCE; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DNA TEMPLATE; DRUG ANTAGONISM; DRUG EFFECT; ESCHERICHIA COLI; GENETIC TRANSCRIPTION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MUTATION; PROMOTER REGION; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE;

BACTERIA (MICROORGANISMS);

AMIDINES; BINDING SITES; CATALYSIS; DNA, BACTERIAL; DNA-DIRECTED RNA POLYMERASES; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; ESCHERICHIA COLI; EXODEOXYRIBONUCLEASES; HYDROXYLAMINES; MODELS, MOLECULAR; MUTATION; NUCLEOTIDES; PHENYLUREA COMPOUNDS; PIPERAZINES; PROMOTER REGIONS (GENETICS); PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PYRAZOLES; RNA, BACTERIAL; TEMPLATES, GENETIC; TRANSCRIPTION, GENETIC;

EID: 0142147268     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1087526     Document Type: Article

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30. Supported by grants from the Department of Agriculture (WIS04022) and NIH (GM38660) to R.L. and additional support from Cumbre, Inc., to I.A. and R.L