Fine tuning of the specificity of an anti-progesterone antibody by first and second sphere residue engineering

Journal of Biological Chemistry

Volumn 280, Issue 26, 2005, Pages 24880-24887

  Dubreuil, Olivier ^a,b   Bossus, Marc ^a,b   Graille, Marc ^a   Bilous, Maëlle ^a   Savatier, Alexandra ^a,b   Jolivet, Michel ^b   Ménez, André ^a   Stura, Enrico ^a   Ducancel, Frédéric ^a,c  

^a DIF   (France)

^b BioMerieux   (France)

^c CEA SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BINDING ENERGY; COMPLEXATION; DATA ACQUISITION; ENZYMES; MUTAGENESIS;

ANTI-PROGESTERONE; CROSS-REACTIVITY; FINE TUNING; MUTATIONS;

ANTIBODIES;

5ALPHA PREGNANE 3,20 DIONE; 5BETA DIHYDROPROGESTERONE; AMINO ACID; ANTIGESTAGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY C12G11; PROGESTERONE; STEROID; UNCLASSIFIED DRUG;

ANTIBODY ENGINEERING; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BACTERIOPHAGE; BINDING SITE; COMPLEMENTARITY DETERMINING REGION; CROSS REACTION; DRUG STRUCTURE; HUMAN; HUMAN CELL; MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

5-ALPHA-DIHYDROPROGESTERONE; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; BINDING SITES; BINDING, COMPETITIVE; BIOSENSING TECHNIQUES; BIOTINYLATION; CLONING, MOLECULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE LIBRARY; HYBRIDOMAS; IMMUNOGLOBULIN FC FRAGMENTS; INHIBITORY CONCENTRATION 50; KINETICS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDE LIBRARY; POLYMERASE CHAIN REACTION; PROGESTERONE; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STEROIDS; SURFACE PLASMON RESONANCE;

EID: 21644486795     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500048200     Document Type: Article

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