Molecular targets of diabetic cardiovascular complications

Current Drug Targets

Volumn 6, Issue 4, 2005, Pages 487-494

  Ahmad, Fatima K ^a   He, Zhiheng ^a   King, George L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Complications; Diabetes mellitus; Inflammation; Oxidative stress; Protein kinase C; Vasculature

Indexed keywords

ACETYLSALICYLIC ACID; ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; ALAGEBRIUM; ALDOSE REDUCTASE INHIBITOR; ALPHA TOCOPHEROL; AMINOGUANIDINE; ASCORBIC ACID; BENFOTIAMINE; BOSENTAN; CARDIOVASCULAR AGENT; CONNECTIVE TISSUE GROWTH FACTOR; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN RECEPTOR ANTAGONIST; ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PHENYLTHIAZOLIUM BROMIDE; POLYOL; PROTEIN INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RUBOXISTAURIN; SORBINIL; THIOCTIC ACID; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; UNCLASSIFIED DRUG; ZENARESTAT;

ALCOHOL METABOLISM; BLOOD GLUCOSE MONITORING; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CYTOKINE RELEASE; DIABETES MELLITUS; DIABETIC ANGIOPATHY; DIABETIC MICROANGIOPATHY; DIABETIC RETINOPATHY; DRUG DESIGN; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; HUMAN; INTRACELLULAR TRANSPORT; MORBIDITY; MORTALITY; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PATHOPHYSIOLOGY; PROTEIN FUNCTION; QUALITY OF LIFE; REVIEW; SIDE EFFECT; VASCULITIS;

ALDEHYDE REDUCTASE; ANIMALS; CYTOKINES; DIABETIC ANGIOPATHIES; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; OXIDATIVE STRESS; PROTEIN KINASE C;

EID: 21444454887     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389450054021990     Document Type: Review

References (106)

1. The Diabetes Control and Complications Trial Research Group (1993) N. Engl. J. Med., 329, 977-986.
2. Rask-Madsen, C., He, Z., King, G.L. (2005) In Joslin's Diabetes Mellitus, (Kahn, R.C., Weir, G.C., King, G.L., Jacobson, A.M, Moses, A.C, Smith, R.J., Ed.) Lippincott Williams & Wilkins, Boston, MA. pp. 823-837.
3. American Diabetes Association (1993) Diabetes Care, 16, 72-78.
4. Feener, E.P., Dzau, B.J. (2005) In Joslin's Diabetes Mellitus, (Kahn, R.C., Weir, G.C., King, G.L., Jacobson, A.M., Moses, A.C., Smith, R.J., Ed.) Lippincott, Williams & Wilkins, Boston, MA. pp. 867-884.
5. Lusis, A.J. (2000) Nature, 407, 233-241.
6. The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group (2003) N. Engl. J. Med., 348, 2294-2303.
7. Kannel, W.B., Hjortland, M. and Castelli, W.P. (1974) Am. J. Cardiol., 34, 29-34.
8. Spector, K.S. (1998) Clin. Cardiol., 21, 885-7.
9. Hotta, N. (1997) Nagoya. J. Med. Sci., 60, 89-100.
10. Cameron, N.E., Leonard, M.B., Ross, I.S., Whitin. P.H. (19861) Diabetologia, 29, 168-174.
11. Mauer, S.M., Steffes, M.W., Azar, S., Brown, D.M. (1989) Diabetes, 38, 839-46.
12. Robison, W.G., Nagata, M., Laver, N., Hohman, T.C., Kinoshita, J.H. (1989) Invest. Ophthalmol. Vis. Sci., 30, 2285-92.
13. Kador, P.F., Akagi, Y., Takahashi, Y., Ikebe, H., Wyman, M., Kinoshita, J.H. (1990) Arch. Ophthalmol., 108, 1301-9.
14. Engerman, R.L., Kern, T.S. and Larson, M.E. (1994) Diabetologia, 37, 141-4.
15. Greene, D.A., Arezzo, J.C. and Brown, M. B. (1999) Neurology, 53, 580-.
16. Brownlee, M., Cerami, A., Vlassara, H. (1988) N. Engl. J. Med., 318, 1315-21.
17. Schmidt, A.M., Hori, O., Brett, J., Yan, S.D., Wautier, J.L., Stern, D. (1994) Arterioscler. Thromb., 14, 1521-8.
18. Haitoglou, C., Tsilibary, E., Brownlee, M. and Charonis, A. (1992) J. Biol. Chem., 267, 12404-12407.
19. Bucala, R., Mitchell, R., Arnold, K., Innerarity, T., Vlassara, H. and Cerami, A. (1995) J. Biol. Chem., 270, 10828-10832.
20. Bucala, R., Makita, Z., Koschinsky, T., Cerarm, A. and Vlassara, H. (1993) Proc. Natl. Acad. Sci. USA, 90, 6434-6438.
21. Schmidt, A.M. and Stern, D.M. (12000) Trends Endocrinol. Metab., 11, 368-375.
22. Yan, S., Schmidt, A., Anderson, G., Zhang, J., Brett, J., Zou, Y., Pinsky, D. and Stern, D. (1994) J. Biol. Chem., 269, 9889-9897.
23. Schmidt, A.M., Yan, S.D., Brett, J., Mora, R., Nowygrod, R., Stern, D. (1993) J. Clin. Invest., 91, 2155-68.
24. Soulis-Liparota, T., Cooper, M., Papazoglou, D., Clarke, B., Jerums, G. (1991) Diabetes, 40, 1328-34.
25. Hammes, H., Martin, S., Federlin, K., Geisen, K. and Brownlee, M. (1991) Proc. Natl. Acad. Sci. USA, 88, 11555-11558.
26. Stadler, K., Jenei V., Somoghi, A., Jakus, J. (2004) Orv. Hetil, 145, 2491-6.
27. Bolton, W.K., Cattran, D.C., Williams, M.E., Adler, S.G., Appel, G.B., Cartwright, K., Foiles, P.G., Freedman, B.I., Raskin, P., Ratner, R.E., Spinowitz, B.S., Whittier, F.C., Wuerth, J.P.; ACTION I Investigator Group (2004) Am. J. Nephrol., 24, 32-40.
28. Bakris, G.L., Bank, A.J., Kass, D.A., Neutel, J.M., Preston, R.A. and Oparil, S. (2004) Am. J. Hyper., 17, S23-S30.
29. Hanford, L.E., Enghild, J.J., Vainickova, Z., Petersen, S.V., Schaefer, L.M., Schaefer, T.M., Reinhart, T.A. and Oury, T.D. (2004) J. Biol. Chem., 279, 50019-50024.
30. Nishikawa, T. Edelstein, D., Du, X.L., Yamagishi, S., Matsumura, T., Kaneda, Y., Yorek, M.A., Beebe, D., Oates, P.J., Hammes, H.P., Giardino, I., Brownlee, M. (2000) Nature, 404, 787-790.
31. Kuroki, T., Isshiki, K. and King, G.L. (2003) J. Am. Soc. Nephrol., 14, S216-220.
32. Wautier, M.-P., Chappey, O., Corda, S., Stern, D.M., Schmidt, A.M. and Wautier, J.-L. (2001) Am. J. Physiol. Endocrinol. Metab., 280, E685-694.
33. He, Z., Rask-Madsen, C., King, G.L. (2004) In International Textbook of Diabetes Mellitus, (DeFronzo, R.A., Ferrannini, E., Keen, H., Zimmet, P., Ed.) John Wiley & Sons, Ltd., Chichester. pp. 1135-59.
34. Jain, S.K., McVie, R. (1994) Metabolism, 43, 306-9.
35. Jennings, P.E., Chirico, S., Jones A.F., Lunec, J., Barnett, A.H. (1987) Diabetes Res., 6, 151-4.
36. Karpen, C.W., Cataland, S., O'Dorisio T.M., Panganamala, R.V. (1985) Diabetes, 34, 526-31.
37. Oberly, L.W. (1988) Free Radic. Biol. Med., 5, 113-24.
38. Keaney, J.F. Jr., Larson, M.G., Vasan, R.S., Wilson, P.W., Lipinska, I., Corey, D., Massaro, J.M., Sutherland, P., Vita, J.A., Benjamin, E.J., Framingham Study. (2003) Arterioscler. Thromb. Vasc. Biol., 23, 434-439.
39. Sheetz, M.J,, King, G.L. (2002) JAMA, 288, 2579-88.
40. Kowluru, R.A., Tang, J. and Kern, T.S. (2001) Diabetes, 50, 1938-1942.
41. Coppey, L.J., Gellett, J.S., Davidson, E.P., Dunlap, J.A., Lund, D.D. and Yorek, M.A. (2001) Diabetes, 50, 1927-1937.
42. Scott, J.A. and King, G.L. (2004) Ann. N.Y. Acad. Sci., 1031, 204-213.
43. Ting, H.H., Timimi, F.K., Boles, K.S., Creager, S.J., Ganz, P. and Creager, M.A. (1996) J. Clin. Invest., 97, 22-28.
44. Lonn, E., Yusuf, S., Hoogwerf, B., Pogue, J., Yi, Q., Zinman, B., Bosch, J., Dagenais, G., Mann, J.F., Gerstein, H.C., HOPE Study; MICRO-HOPE Study. (2002) Diabetes Care, 25, 1919-1927.
45. Economides, P.A., Khaodhiar, L., Caselli, A., Caballero, A.E., Keenan, H., Bursell, S.E., King, G.L., Johnstone, M.T,, Horton, E.S., Veves, A. (2005) Diabetes, 54, 204-211.
46. Brownlee, M. (2001) Nature, 414, 813-820.
47. Heart Outcomes Prevention Evaluation (HOPE) Study Investigators. (2000) The Lancet, 355, 253-259.
48. Cayatte, A.J., Rupin, A., Oliver-Krasinski, J., Maitland, K., Sansilvestri-Morel, P., Boussard, M.F., Wierzbicki, M., Verbeuren, T.J., Cohen, R.A. (2001) Arterioscler. Thromb. Vasc. Biol., 21, 1577-1584.
49. Hammes, H.-P., Du, X., Edelstein, D., Taguchi, T., Matsumura, T., Ju, Q., Lin, J., Bierhaus, A., Nawroth, P., Hannak, D., Neumaier, M., Bergfeld, R., Giardino, I., Brownlee, M. (2003) Nat. Med., 9, 294-299.
50. Stracke, H., Hammes, H.P., Werkmann, D., Mavrakis, K., Bitsch, I., Netzel, M., Geyer, J., Kopcke, W., Sauerland, C., Bretzel, R.G., Federlin, K.F. (2001) Exp. Clin. Endocrinol. Diabetes, 109, 330-6.
51. Babaei-Jadidi, R., Karachalias, N., Ahmed, N., Battah, S. and Thornalley, P.J. (2003) Diabetes, 52, 2110-2120.
52. Babaei-Jadidi, R., Karachalias, N., Kupich, C., Ahmed, N. and Thornalley, P.J. (2004) Diabetologia, 47, 2235-2246.
53. Haupt, E., Ledermann, H. and Kopcke, W. (2005) Int. J. Clin. Pharmacol. Ther., 43, 71-7.
54. Inoguchi, T., Battan, R., Handler, E., Sportsman, J., Heath, W. and King, G. (1992) Proc. Natl. Acad. Sci. USA, 89, 11059-11063.
55. Xia, P., Inoguchi, T., Kern, T.S., Engerman, R.L., Oates, P.J. and King, G.L. (1994) Diabetes, 43, 1122-9.
56. Inoguchi, T., Xia, P., Kunisaki, M., Higashi, S., Feener, E.P. and King, G.L. (1994) Am. J. Physiol., 267, E369-79.
57. Koya, D. and King, G. (1998) Diabetes, 47, 859-866.
58. Koya, D., Jirousek, M.R., Lin, Y.-W., Ishii, H., Kuboki, K. and King, G.L. (1997) J. Clin. Invest., 100, 115-126.
59. Xia, P., Aiello, L.P., Ishii, H., Jiang, Z.Y., Park, D.J., Robinson, G.S., Takagi, H., Newsome, W.P., Jirousek, M.R., King, G.L. (1996) J. Clin. Invest., 98, 2018-2026.
60. Inoguchi, T., Li, P., Umeda, F., Yu, H.Y., Kakimoto, M., Imamura, M., Aoki, T., Etoh, T., Hashimoto, T., Naruse, M., Sano, H., Utsumi, H., Nawata, H. (2000) Diabetes, 49, 1939-1945.
61. Glogowski, E.A., Tsiani, E., Zhou, X., Famus, I.G. and Whiteside, C. (1999) Kidney Int., 55, 486-499.
62. Kuboki, K., Jiang, Z.Y., Takahara, N., Ha, S.W., Igarashi, M., Yamauchi, T., Feener, E.P., Herbert, T.P., Rhodes, C.J., King, G.L. (2000) Circulation, 101, 676-681.
63. Williams, B., Gallacher, B., Patel, H. and Orme, C. (1997) Diabetes, 46, 1497-503.
64. Feener, E.P., Xia, P., Inoguchi, T., Shiba, T., Kunisaki, M. and King, G.L. (1996) Contrib. Nephrol., 118, 180-7.
65. Ishii, H., Jirousek, M.R., Koya, D., Takagi, C., Xia, P., Clermont, A., Bursell, S.E., Kern, T.S., Ballas, L.M., Heath, W.F., Stramm, L.E., Feener, E.P., King, G.L. (1996) Science, 272, 728-31.
66. Aiello, L.P., Bursell, S.E., Clermont, A., Duh, E., Ishii, H., Takagi, C., Mori, F., Ciulla, T.A., Ways, K., Jirousek, M., Smith, L.E., King, G.L. (1997) Diabetes, 46, 1473-80.
67. Danis, R.P., Bingaman, D.P., Jirousek, M. and Yang, Y. (1998) Invest. Ophthalmol. Vis. Sci., 39, 171-9.
68. Koya, D., Haneda, M., Nakagawa, H., Isshiki, K., Sato, H., Maeda, S., Sugimoto, T., Yasuda, H., Kashiwagi, A., Ways, D.K., King, G.L., Kikkawa, R. (2000) FASEB J., 14, 439-447.
69. Beckman, J.A., Goldfine, A.B., Gordon, M.B., Garrett, L.A., Creager, M.A. (2002) Circ. Res., 90, 107-11.
70. Bowling, N., Walsh, R.A., Song, G., Estridge, T., Sandusky, G.E., Fouts, R.L., Mintze, K., Pickard, T., Roden, R., Bristow, M.R., Sabbah, H.N., Mizrahi, J.L., Gromo, G., King, G.L., Vlahos, C.J. (1999) Circulation, 99, 384-391.
71. Schram, M.T., Chaturvedi, N., Schalkwijk, C., Giorgino, F., Ebeling, P., Fuller, J.H. and Stehouwer, C.D. (2003) Diabetes Care, 26, 2165-2173.
72. Cosentino, F., Eto, M, De Paolis, P., van der Loo, B., Bachschmid, M., Ullrich, V., Kouroedov, A., Delli Gatti, C., Joch, H., Volpe, M., Luscher, T.F. (2003) Circulation, 107, 1017-1023.
73. Bucciarelli, L.G., Wendt, T., Qu, W., Lu, Y., Lalla, E., Rung, L.L., Goova, M.T., Moser, B., Kislinger, T., Lee, D.C., Kashyap, Y., Stern, D.M., Schmidt, A.M. (2002) Circulation, 106, 2827-2835.
74. Joussen, A.M., Poulaki, V., Mitsiades, N., Kirchhof, B., Koizumi, K., Dohmen, S. and Adamis, A.P. (2002) FASEB J., 16, 439-440.
75. ETDRS Investigators. (1991) Ophthalmology, 98, 757-65.
76. ETDRS Investigators. (1992) JAMA, 268, 1292-300.
77. Qaum, T., Xu, Q., Joussen, A.M., Clemens, M.W., Qin, W., Miyamoto, K., Hassessian, H., Wiegand, S.J., Rudge, J., Yancopoulos, G.D., Adamis, A.P. (2001) Invest. Ophthalmol. Vis. Sci., 42, 2408-2413.
78. Adamis, A.P., Miller, J.W., Bernal, M.T., D'Amico, D.J., Folkman, J., Yeo, T.K. and Yeo, K.T. (1994) Am. J. Ophthalmol., 118, 445-50.
79. Flyvbjerg, A., Dagnaes-Hansen, F., De Vriese, A.S., Schrijvers, B.F., Tilton, R.G. and Rasch, R. (2002) Diabetes, 51, 3090-3094.
80. Chou, E., Suzuma, I., Way, K.J., Opland, D., Clermont, A.C., Naruse, K., Suzuma, K., Bowling, N.L., Vlahos, C.J., Aiello, L.P., King, G.L. (2002) Circulation, 105, 373-379.
81. Sharma, K., Ziyadeh, F.N., Alzahabi, B., McGowan, T.A., Kapoor, S., Kurnik, B.R., Kurnik, P.B. and Weisberg, L.S. (1997) Diabetes, 46, 854-9.
82. Sharma, K., Jin, Y., Guo, J. and Ziyadeh, F.N. (1996) Diabetes, 45, 522-30.
83. Han, D.C., Hoffman, B.B., Hong, S.W., Guo, J. and Ziyadeh, F.N. (2000) Am. J. Physiol. Renal. Physiol., 278, F628-634.
84. Chen, H.-C., Bouchie, J.L., Perez, A.S., Clermont, A.C., Izumo, S., Hampe, J. and Feener, E.P. (2000) Arterioscler. Thromb. Vasc. Biol., 20, 2297-2302.
85. Ziyadeh, F.N., Hoffman, B.B., Han, D.C., Iglesias-De La Cruz, M.C., Hong, S.W., Isono, M., Chen, S., McGowan, T.A., Sharma, K. (2000) Proc. Natl. Acad Sci. USA, 97, 8015-8020.
86. Moussad, E.E., Brigstock, D.R. (2000) Mol. Genet. Metab., 71, 276-292.
87. Murphy, M., Godson, C., Cannon, S., Kato, S., Mackenzie, H.S., Martin, F. and Brady, H.R. (1999) J. Biol. Chem., 274, 5830-5834.
88. Duncan, M.R., Frazier, K.S., Abramson, S., Williams, S., Klapper, H., Huang, X. And Grotendorst, G.R. (1999) FASEB J., 13, 1774-1786.
89. Gavras, H. and Brunner, H.R. (2001) Hypertension, 37, 342-345.
90. Sowers, J.R., Epstein, M. and Frohlich, F.D. (2001) Hypertension, 37, 1053-1059.
91. Winer, N., Weber, M.A. and Sowers, J.R. (2001) Curr. Hypertens. Rep., 3, 297-304.
92. Dzau, V.J. (2001) Hypertension, 37, 1047-1052.
93. Kagami, S., Border, W.A., Miller, D.E. and Noble, N.A. (1994) J. Clin. Invest., 93, 2431-7.
94. Pupilli, C., Lasagni, L., Romagnani, P., Bellini, F., Mannelli, M., Misciglia, N., Mavilia, C., Vellei, U., Villari, D., Serio, M. (1999) J. Am. Soc. Nephrol., 10, 245-255.
95. Feener, E.P. (2001) In Diabetes and Cardiovascular Disease (Johnston, M.T., Veves, A., Ed.) Humana press, Totowa, NJ.
96. Folli, F., Kahn, C.R., Hansen, H., Bouchie, J.L. and Feener, E.P. (1997) J. Clin. Invest., 100, 2158-2169.
97. Lewis, E.J., Hunsicker, L.G., Bain, R.P., Rohde, R.D. and The Collaborative Study Group (1993) N. Engl. J. Med., 329, 1456-1462.
98. Hogeboom van Buggenum, I.M., Polak, B.C., Reichert-Thoen, J.W., de Vries-Knoppert, W.A., van Hinsbergh, V.W., Tangelder, G.J. (2002) Diabetologia, 45, 203-209.
99. Chaturvedi, N., Sjolie, A.K., Stephenson, J.M., Abrahamian, H., Keipes, M., Castellarin, A., Rogulja-Pepeonik, Z., Fuller, J.H. (1998) The Lancet, 351, 28-31.
100. Malik, R.A., Williamson, S., Abbott, C., Carrington, A.L., Iqbal, J., Schady, W. and Boulton, A.J.M. (1998) The Lancet. 352, 1978-1981.
101. UK Prospective Diabetes Study Group (1998) BMJ, 317, 703-713.
102. Cardillo, C., Campia, U., Bryant, M.B. and Panza, J.A. (2002) Circulation, 106, 1783-1787.
103. Cameron, N.E. and Cotter, M.A. (1996) J. Pharmacol. Esp. Ther., 278, 1262-8.
104. Nakamura, T., Ebihara, I., Fukui, M., Tomino, Y. and Koide, H. (1995) Diabetes, 44, 895-9.
105. Deng, D., Evans, T., Mukherjee, K., Downey, D. and Chakrabarti, S. (1999) Diabetologia, 42, 1228-1234.
106. Jandeleit-Dahm, K., Allen, T.J., Youssef, S., Gilbert, R.E. and Cooper, M.E. (2000) Diabetes Obes. Metab., 2, 15-24.