Advanced glycation end-product cross-link breakers: A novel approach to cardiovascular pathologies related to the aging process

American Journal of Hypertension

Volumn 17, Issue 12 SUPPL., 2004, Pages S23-S30

  Bakris, George L ^a   Bank, Alan J ^b   Kass, David A ^c   Neutel, Joel M ^d   Preston, Richard A ^e   Oparil, Suzanne ^f  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b St Paul Heart Clinic   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d Orange County Research Center   (United States)

^e UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Advanced glycation end products; aging; alagebrium; cardiovascular stiffness; collagen; cross link breaker; diastolic heart failure; systolic hypertension

Indexed keywords

ADVANCED GLYCATION END PRODUCT CROSS LINK BREAKER; ALAGEBRIUM; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; UNCLASSIFIED DRUG;

AGING; ARTERY COMPLIANCE; ARTERY TONE; BACKACHE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CONCENTRATION LOSS; COUGHING; DIZZINESS; DRUG EFFICACY; DRUG FATALITY; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; EUPHORIA; HEADACHE; HEART FAILURE; HEART INFARCTION; HEART OUTPUT; HUMAN; HYPERTENSION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; SKIN TINGLING; SUDDEN DEATH; SYSTOLIC BLOOD PRESSURE; SYSTOLIC HYPERTENSION; UPPER RESPIRATORY TRACT INFECTION; URINARY TRACT INFECTION; VISUAL IMPAIRMENT;

EID: 10644246127     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjhyper.2004.08.022     Document Type: Article

References (42)

1. P. Ulrich, A. Cerami Protein glycation, diabetes, and aging Recent Prog Horm Res 56 2001 1 22
2. M.J.C. Kent, N.D. Light, A.J. Bailey Evidence for glucose-mediated covalent cross-linking of collagen after glycosylation in vitro Biochem J 225 1985 745 752
3. G. Jerums, S. Panagiotopoulos, J. Forbes, T. Osicka, M. Cooper Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease Arch Biochem Biophys 419 2003 55 62
4. G. Pugliese, F. Pricci, C. Iacobini, G. Leto, L. Amadio, P. Barsotti, L. Frigeri, D.K. Hsu, H. Vlassara, F.T. Liu, U. Di Mario Accelerated diabetic glomerulopathy in galectin-3/AGE receptor 3 knockout mice FASEB J 15 2001 2471 2479
5. C. Iacobini, L. Amadio, G. Oddi, C. Ricci, P. Barsotti, S. Missori, M. Sorcini, U. Di Mario, F. Pricci, G. Pugliese Role of galectin-3 in diabetic nephropathy (review) J Am Soc Nephrol 14 8 Suppl 3 2003 S264 S270
6. M. Neeper, A.M. Schmidt, J. Brett, S.D. Yan, F. Wang, Y.C. Pan, K. Elliston, D. Stern, A. Shaw Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins J Biol Chem 267 1992 14998 15004
7. A.M. Schmidt, S.D. Yan, S.F. Yan, D.M. Stern The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses J Clin Invest 108 2001 949 955
8. D. Aronson, E.J. Rayfield How hyperglycemia promotes atherosclerosis molecular mechanisms Cardiovasc Diabetol 1 2002 1
9. M. Asif, J. Egan, S. Vasan, G.N. Jyothirmayi, M.R. Masurekar, S. Lopez, C. Williams, R.L. Torres, D. Wagle, P. Ulrich, A. Cerami, M. Brines, T.J. Regan An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness Proc Natl Acad Sci USA 97 2000 2809 2813
10. D.A. Kass, J.G. Bronzwaer, W.J. Paulus What mechanisms underlie diastolic dysfunction in heart failure? Circ Res 94 2004 1533 1542
11. F. Kuwahara, H. Kai, K. Tokuda, M. Takeya, A. Takeshita, K. Egashira, T. Imaizumi Hypertensive myocardial fibrosis and diastolic dysfunction another model of inflammation? Hypertension 43 2004 739 745
12. K.L. Herrmann, A.D. McCulloch, J.H. Omens Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy Am J Physiol Heart Circ Physiol 284 2003 H1277 H1284
13. G. Basta, G. Lazzerini, M. Massaro, T. Simoncini, P. Tanganelli, C. Fu, T. Kislinger, D.M. Stern, A.M. Schmidt, R. De Caterina Advanced glycation end products activate endothelium through signal-transduction receptor RAGE a mechanism for amplification of inflammatory responses Circulation 105 2002 816 822
14. S.M. Twigg, M.M. Chen, A.H. Joly, S.D. Chakrapani, J. Tsubaki, H.S. Kim, O.H. Youngman, R.G. Rosenfeld Advanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein-related protein 2) in human fibroblasts a potential mechanism for expansion of extracellular matrix in diabetes mellitus Endocrinology 142 2001 1760 1769
15. S. Vasan, P. Foiles, H.W. Founds Therapeutic potential of AGE-inhibitors and breakers of AGE-protein crosslinks (review) Expert Opin Investig Drugs 10 2001 1977 1987
16. K.E. Airaksinen, P.I. Salmela, M.K. Linnaluoto, M.J. Ikaheimo, K. Ahola, L.J. Ryhanen Diminished arterial elasticity in diabetes association with fluorescent advanced glycosylation end products in collagen Cardiovasc Res 27 1993 942 945
17. H.M. Raabe, H. Molsen, S.M. Mlinaric, Y. Acil, G.H. Sinnecker, H. Notbohm, K. Kruse, P.K. Muller Biochemical alterations in collagen IV induced by in vitro glycation Biochem J 9 1996 699 704
18. D. Aronson Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes J Hypertens 21 2003 3 12
19. S.J. Zieman, D.A. Kass Advanced glycation endproduct crosslinking in the cardiovascular system potential therapeutic target for cardiovascular disease Drugs 64 2004 459 470
20. D.W. Kitzman, M.R. Zile, W.C. Little, W.G. Hundley, T.X. O'Brien, R.C. deGroof Effect of ALT-711, a novel glucose cross-link breaker, in the treatment of diastolic heart failure (abstract) Eur Heart J 24 Suppl 2003 408
21. S. Vasan, X. Zhang, X. Zhang, A. Kapurniotu, J. Bernhagen, S. Teichberg, J. Basgen, D. Wagle, D. Shih, I. Terlecky, R. Bucala, A. Cerami, J. Egan, P. Ulrich An agent cleaving glucose-derived protein crosslinks in vitro and in vivo Nature 382 1996 275 278
22. M.S. Huijberts, B.H. Wolffenbuttel, H.A. Boudier, F.R. Crijns, A.C. Kruseman, P. Poitevin, B.I. Levy Aminoguanidine treatment increases elasticity and decreases fluid filtration of large arteries from diabetic rats J Clin Invest 92 1993 1407 1411
23. B.H. Wolffenbuttel, C.M. Boulanger, F.R. Crijns, M.S. Huijberts, P. Poitevin, G.N. Swennen, S. Vasan, J.J. Egan, P. Ulrich, A. Cerami, B.I. Levy Breakers of advanced glycation end products restore large artery properties in experimental diabetes Proc Natl Acad Sci USA 95 1998 4630 4634
24. P.V. Vaitkevicius, M. Lane, H. Spurgeon, D.K. Ingram, G.S. Roth, J.J. Egan, S. Vasan, D.R. Wagle, P. Ulrich, M. Brines, J.P. Wuerth, A. Cerami, E.G. Lakatta A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys Proc Natl Acad Sci USA 98 2001 1171 1175
25. J. Liu, M.R. Masurekar, D.E. Vatner, G.N. Jyothirmayi, T.J. Regan, S.F. Vatner, L.G. Meggs, A. Malhotra Glycation end-product cross-link breaker reduces collagen and improves cardiac function in aging diabetic heart Am J Physiol Heart Circ Physiol 285 2003 H2587 H2591
26. D. Susic, J. Varagic, J. Ahn, E.D. Frohlich Cardiovascular and renal effects of a collagen cross-link breaker (ALT-711) in adult and aged spontaneously hypertensive rats Am J Hypertens 17 2004 328 333
27. R. Candido, J.M. Forbes, M.C. Thomas, V. Thallas, R.G. Dean, W.C. Burns, C. Tikellis, R.H. Ritchie, S.M. Twigg, M.E. Cooper, L.M. Burrell A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes Circ Res 92 2003 785 792
28. J.M. Forbes, L.T. Yee, V. Thallas, M. Lassila, R. Candido, K.A. Jandeleit-Dahm, M.C. Thomas, W.C. Burns, E.K. Deemer, S.M. Thorpe, M.E. Cooper, T.J. Allen Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis Diabetes 53 2004 1813 1823
29. G.E. McVeigh, C.W. Bratteli, D.J. Morgan, C.M. Alinder, S.P. Glasser, S.M. Finkelstein, J.N. Cohn Age-related abnormalities in arterial compliance identified by pressure pulse contour analysis aging and arterial compliance Hypertension 33 1999 1392 1398
30. J.R. Cockcroft, D.J. Webb, I.B. Wilkinson Arterial stiffness, hypertension and diabetes mellitus J Hum Hypertens 14 2000 377 380
31. S.S. Franklin, M.G. Larson, S.A. Khan, N.D. Wong, E.P. Leip, W.B. Kannel, D. Levy Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study Circulation 103 2001 1245 1249
32. R.J. Glynn, C.U. Chae, J.M. Guralnik, J.O. Taylor, C.H. Hennekens Pulse pressure and mortality in older people Arch Intern Med 160 2000 2765 2772
33. V. Vaccarino, T.R. Holford, H.M. Krumholz Pulse pressure and risk for myocardial infarction and heart failure in the elderly J Am Coll Cardiol 36 2000 130 138
34. D.A. Kass, E.P. Shapiro, M. Kawaguchi, A.R. Capriotti, A. Scuteri, R.C. deGroof, E.G. Lakatta Improved arterial compliance by a novel advanced glycation end-product crosslink breaker Circulation 104 2001 1464 1470
35. American Heart Association. Statistical Fact Sheet-Populations. Older Americans and Cardiovascular Diseases. 2004. http://www.americanheart.org/ downloadable/heart/1075718681641FS08OLD4.pdf
36. M.R. Zile, D.L. Brutsaert New concepts in diastolic dysfunction and diastolic heart failure. Part 1: Diagnosis, prognosis, and measurement of diastolic function Circulation 105 2002 1387 1393
37. M. Kawaguchi, I. Hay, B. Fetics, D.A. Kass Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction implications for systolic and diastolic reserve limitations Circulation 107 2003 714 720
38. American Heart Association Heart disease and stroke statistics 2004 update
39. M.E. Safar Epidemiological findings imply that goals for drug treatment of hypertension need to be revised Circulation 103 2001 1188 1190
40. C.B. Spranger, A.J. Ries, C.A. Berge, N.B. Radford, R.G. Victor Identifying gaps between guidelines and clinical practice in the evaluation and treatment of patients with hypertension Am J Med 117 2004 14 18
41. M.D. Safar, G.M. London (GRP) Therapeutic studies and arterial stiffness in hypertension: recommendations of the European Society of Hypertension. The Clinical Committee of Arterial Structure and Function. Working Group on Vascular Structure and Function of the European Society of Hypertension (review) J Hypertens 18 2000 1527 1535
42. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure Arch Intern Med 157 1997 2413 2446