Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart

Circulation

Volumn 99, Issue 3, 1999, Pages 384-391

  Bowling, Nancy ^a   Walsh, Richard A ^e   Song, Guojie ^e   Estridge, Thomas ^a   Sandusky, George E ^a   Fouts, Rebecca L ^a   Mintze, Karen ^a   Pickard, Todd ^a   Roden, Robert ^b   Bristow, Michael R ^b   Sabbah, Hani N ^c   Mizrahi, Jacques L ^a   Gromo, Gianni ^a   King, George L ^d   Vlahos, Chris J ^a  

^a ELI LILLY AND COMPANY   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c HENRY FORD HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e NONE

Author keywords

Cardiomyopathy; Heart failure; Hypertrophy; Myocytes; Signal transduction

Indexed keywords

PROTEIN KINASE C;

ADULT; AGED; ARTICLE; ENZYME ACTIVITY; FEMALE; HEART FAILURE; HUMAN; HUMAN TISSUE; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0032917447     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.99.3.384     Document Type: Article

References (34)

1. Davies CH, Harding SE, Poole-Wilson PA. Cellular mechanisms of contractile dysfunction in human heart failure. Eur Heart J. 1996;17: 189-198.
2. Dunnmon PM, Iwaki K, Henderson SA, Sen A, Chien KR. Phorbol esters induce immediate-early genes and activate cardiac gene transcription in neonatal rat myocardial cells. J Mol Cell Cardiol. 1990;22:901-910.
3. Chien KR, Knowlton KU, Zhu H, Chien S. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. FASEB J. 1991;5:3037-3046.
4. Gu X, Bishop SP. Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat. Circ Res. 1994;75: 926-931.
5. Steinberg SF, Goldberg M, Rybin VO. Protein kinase C isoform diversity in the heart. J Mol Cell Cardiol. 1995;27:141-153.
6. Disatnik MH, Buraggi G, Mochly-Rosen D. Localization of protein kinase C isozymes in cardiac myocytes. Exp Cell Res. 1994;210:287-297.
7. Kohout TA, Rogers TB. Use of PCR-based method to characterize protein kinase C isoform expression in cardiac cells. Am J Physiol. 1993;264:C1350-C1359.
8. Goldberg M, Steinberg SF. Tissue-specific developmental regulation of protein kinase C isoforms. Biochem Pharmacol. 1996;51:1089-1093.
9. Inoguchi T, Battan R, Handler E, Sportsman JR, Heath W, King GL. Preferential elevation of protein kinase C isoform βII and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A. 1992;89:11059-11063.
10. Wakasaki H, Koya D, Schoen FJ, Lipes M, Jirousek MR, Ways K, Hoit BD, Walsh RA, King GL. Targeted overexpression of protein kinase C β2 in myocardium causes cardiomyopathy. Proc Natl Acad Sci U S A. 1997; 94:9320-9325.
11. Bowman JC, Steinberg SF, Jiang T, Geenen DL, Fishman GI, Buttrick PM. Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates. J Clin Invest. 1997;100: 2189-2195.
12. Strasser RH, Briem SK, Vahl CF, Lange R, Hagl S, Kubler W. Selective expression of cardiac protein kinase C-isoforms in chronic heart failure and myocardial hypertrophy. Circulation. 1996;94(suppl I):I-551. Abstract.
13. Erdbrugger W, Keffel J, Knocks M, Otto T, Philipp T, Michel MC. Protein kinase C isoenzymes in rat and human cardiovascular tissues. Br J Pharmacol. 1997;120:177-186.
14. Ishii H, Jirousek MR, Koya D. Takagi C, Xia P, Clermont A. Bursell S-E, Kern TS, Ballas LM, Heath WF, Stramm LE, Feener EP, King GL. Ameliorization of vascular dysfunctions in diabetic rats by an oral PKC-β inhibitor. Science. 1996;272:728-731.
15. Paul K, Ball NA, Dorn GW II, Walsh RA. Left ventricular stretch stimulates angiotensin II-mediated phosphatidylinositol hydrolysis and protein kinase C epsilon isoform translocation in adult guinea pig hearts. Circ Res. 1997;81:643-650.
16. Puceat M, Hilal-Dandan R, Strulovici B, Brunton LL, Brown JH. Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes. J Biol Chem. 1994;269:16938-16944.
17. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-253.
18. Ping P. Zhang J, Qiu Y, Tang X-L, Manchikalapudi S, Cao X, Bolli R. Ischemic preconditioning induces selective translocation of protein kinase C isoforms ∈ and η in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity. Circ Res. 1997;81: 404-414.
19. Nishizuka Y. Studies and perspectives of protein kinase C. Science. 1986;233:305-312.
20. Watson PA. Mechanical activation of signaling pathways in the cardiovascular system. Trends Cardiovasc Med. 1996;6:73-79.
21. Rouet-Benzineb P, Mohammadi K, Perennec J, Poyard M, El Houda Bouanani NEH, Crozatier B. Protein kinase C isoform expression in normal and failing rabbit hearts. Circ Res. 1996;79:153-161.
22. Koya D, Jirousek MR, Lin Y-W, Ishii H, Kuboki K, King GL. Characterization of protein kinase C β isoform activation on the gene expression of transforming growth factor-β, extracellular matrix components, and prostanoids in the glomerali of diabetic rats. J Clin Invest. 1997;100: 115-126.
23. Nadal-Ginard B, Mahdavi V. Molecular basis of cardiac performance. Plasticity of the myocardium generated through protein isoform switches. J Clin Invest. 1989;84:1693-1709.
24. Boheler KR, Schwartz K. Gene expression in cardiac hypertrophy. Trends Cardiovasc Med. 1992;2:176-182.
25. Simpson PC, Long CS, Waspe LE, Henrich CH, Ordahl CP. Transcription of early development isogenes in cardiac myocyte hypertrophy. J Mol Cell Cardiol. 1989;21(suppl 5):79-89.
26. Kariya K-I, Karns LR, Simpson PC. An enhancer core element mediates stimulation of the rat β-myosin heavy chain promoter by an α1-adrenergic agonist and activated β-protein kinase C in hypertrophy of cardiac myocytes. J Biol Chem. 1994;269:3775-3782.
27. Sadoshima J. Izumo S. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. EMBO J. 1993;12:1681-1692.
28. Jiang T, Pak E, Zhang HL, Kline RP, Steinberg SF. Endothelin-dependent actions in cultured AT-1 cardiac myocytes. The role of the ∈ isoform of protein kinase C. Circ Res. 1996;78:724-736.
29. Kariya K-I, Karns LR, Simpson PC. Expression of a constitutively activated mutant of the beta-isozyme of protein kinase C in cardiac myocytes stimulates the promoter of the beta-myosin heavy chain isogene. J Biol Chem. 1991;266:10023-10026.
30. Decock JB. Gillespie-Brown J, Parker PJ, Sugden PH, Fuller SJ. Classical, novel and atypical isoforms of PKC stimulate ANF- and TRE/ AP-1-regulated-promotor activity in ventricular cardiomyocytes. FEBS Lett. 1994;356:275-278.
31. Litwin SE, Morgan JP. Captopril enhances intracellular calcium handling and β-adrenergic responsiveness of myocardium from rats with postin-farction failure. Circ Res. 1992;71:797-807.
32. D'Angelo DD, Sakata Y, Lorenz JN, Boivin GP, Walsh RA. Liggett SB, Dorn GW II. Transgenic Gaq overexpression induces cardiac contractile failure in mice. Proc Natl Acad Sci U S A. 1997;94: 8121-8126.
33. Henrich CJ. Simpson PC. Differential acute and chronic response of protein kinase C in cultured neonatal rat heart myocytes to alpha 1-adrenergic and phorbol ester stimulation. J Mol Cell Cardiol. 1988;20: 1081-1085.
34. Mochley-Rosen D, Henrich CJ, Cheever L, Khaner H. Simpson PC. A protein kinase C isozyme is translocated to cytoskeletal elements on activation. Cell Regul. 1990;1:693-706.