Phosphoinositides as spatial regulators of membrane traffic

Current Opinion in Neurobiology

Volumn 7, Issue 3, 1997, Pages 331-338

  Martin, Thomas Fj ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE D; RHO FACTOR;

CELL FUSION; CELL MEMBRANE TRANSPORT; ENDOCYTOSIS; NEUROTRANSMITTER RELEASE; PHOSPHORYLATION; PRIORITY JOURNAL; REVIEW; SECRETORY GRANULE;

EID: 0030838702     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(97)80060-8     Document Type: Article

References (62)

1. De Camilli P, Emr SD, McPherson PS, Novick P. Phosphoinositides as regulators in membrane traffic. Science. 271:1996;1533-1539.
2. Pike LJ, Casey L. Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains. J Biol Chem. 271:1996;26453-26456 See annotation [3]. special interest.
3. 2 pool in A431 cells was reported to reside in a Triton-detergent-resistant, low-density fraction suggested to represent caveolae. special interest.
4. 2 is consequently inhibited. outstanding interest.
5. 2-binding proteins involved in signaling by tyrosine kinase. J Biol Chem. 269:1994;1518-1522.
6. 2+-activated exocytosis. Nature. 374:1995;173-177.
7. Carpenter CL, Cantley LC. Phosphoinositide kinases. Curr Opin Cell Biol. 8:1996;153-158.
8. Nakagawa T, Goto K, Kondo H. Cloning, expression, and localization of 230 kD phosphatidylinositol 4-kinase. J Biol Chem. 271:1996;12088-12094 See annotation [10]. special interest.
9. Gehrmann T, Vereb G, Schmidt M, Klix D, Meyer HE, Varsanyi M, Heilmeyer LMG. Identification of a 200 kD polypeptide as type 3 phosphatidylinositol 4-kinase from bovine brain by partial protein and cDNA sequencing. Biochim Biophys Acta. 1311:1996;53-63 See annotation [101]. special interest.
10. Nakagawa T, Goto K, Kondo H. Cloning and characterization of a 92 kD soluble phosphatidylinositol 4-kinase. Biochem J. 320:1996;643-649 These three papers [8-10] extend the molecular characterization of PI 4-kinases. The cDNAs encode two distinct types of PI 4-kinases. The enzymes characterized in [8,9] are closely related whereas that of [10] is distinct. special interest.
11. Berditchevski F, Tolias KF, Wong K, Carpenter CL, Hemler ME. A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. J Biol Chem. 272:1997;2595-2598.
12. Loijens JC, Boronenkov IV, Parker GJ, Anderson RA. The phosphatidylinositol 4-phosphate 5-kinase family. Adv Enzyme Regul. 36:1996;115-140 A review on the recent progress in the molecular characterization of type I and type II forms of PIP 5-kinase. special interest.
13. Loijens JC, Anderson RA. Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family. J Biol Chem. 271:1996;32937-32943.
14. Ishihara H, Shibasaki Y, Kizuki N, Katagiri H, Yazaki Y, Asano T, Oka Y. Cloning of cDNAs encoding two isoforms of 68kD type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 271:1996;23611-23614.
15. Ren X-D, Bokoch GM, Traynor-Kaplan A, Jenkins GH, Anderson RA, Schwartz MA. Physical association of the small GTPase rho with a 68 kd phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells. Mol Biol Cell. 7:1996;435-442 See annotation [16]. special interest.
16. Tolias KF, Cantley L, Carpenter CL. Rho family GTPases bind to phosphoinositide kinases. J Biol Chem. 270:1995;17656-17659 In these two studies [15,16], immobilized Rho and Rac proteins were found to retain various type I isoforms of PIP 5-kinase. The interactions between Rho/Rac and lipid kinases were not dependent on GTP; it was not determined whether these interactions are direct or mediated by another protein. special interest.
17. Carvajal JJ, Pook MA, dos Santos M, Doudney K, Hillermann R, Minogue S, Williamson R, Hsuan JJ, Chamberlain S. The Friedreich's ataxia gene encodes a novel phosphatidylinositol-4-phosphate 5-kinase. Nat Genet. 14:1996;157-162.
18. Seaman MNJ, Burd CG, Emr S. Receptor signalling and the regulation of endocytic membrane transport. Curr Opin Cell Biol. 8:1996;549-556.
19. Panaretou C, Domin J, Cockcroft S, Waterfield MD. Characterization of p150, an adaptor protein for the human phosphatidylinositol (Ptdlns) 3-kinase. J Biol Chem. 272:1997;2477-2485 This study extends the effort to characterize mammalian homologs of yeast PI 3-kinase VPS34p and its adaptor protein VPS15p. The mammalian VPS15p homolog interacted with a PI 3-kinase and stimulated its activity. special interest.
20. DeVries KJ, Westerman J, Bastiaens PIH, Jovin TM, Wirtz KWA, Snoek GT. Fluorescently labeled phosphatidylinositol transfer protein isoforms (α and β) microinjected into fetal bovine heart endothelial cells are targeted to distinct intracellular sites. Exp Cell Res. 227:1996;33-39.
21. Martin T. New directions for phosphatidylinositol transfer. Curr Biol. 5:1995;990-992.
22. Cunningham E, Tan SK, Swigart P, Hsuan J, Bankaitis V, Cockcroft S. The yeast and mammalian isoforms of phosphatidylinositol transfer protein can all restore phosphalipase C-mediated inositiol lipid signaling in cytosol-depleted RBL-2H3 and HL-60 cells. Proc Natl Acad Sci USA. 93:1996;6589-6593.
23. Ohashi M, deVries KJ, Frank R, Snoek G, Bankaitis V, Wirtz K, Huttner WB. A role for phosphatidylinositol transfer protein in secretory vesicle formation. Nature. 377:1995;544-547.
24. Rothman JE, Wieland FT. Protein sorting by transport vesicles. Science. 272:1996;227-234.
25. Tapon N, Hall A. Rho, rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton. Curr Opin Cell Biol. 9:1997;86-92 A recent review that summarizes potential downstream effectors of Rho family GTPases. special interest.
26. Frohman MA, Morris AJ. Phospholipid signalling: Rho is only ARF the story. Curr Biol. 6:1996;945-947 A recent review that summarizes ARF and Rho regulation of PLD. special interest.
27. 2 and PA. outstanding interest.
28. Pertile P, Liscovitch M, Chalifa V, Cantley LC. Phosphatidylinositol 4,5-bisphosphate synthesis is required for activation of phospholipase D in U937 cells. J Biol Chem. 270:1995;5130-5135 The authors showed that GTPγS activation of PLD activity in permeable cells is potentiated by MgATP, inhibited by neomycin and by type II PI 4-kinase antibodies. special interest.
29. 2, indicating that these forms of regulation are direct. outstanding interest.
30. 2-containing liposomes. special interest.
31. Terui T, Kahn RA, Randazzo PA. Effects of acid phospholipids on nucleotide exchange properties of ADP-ribosylation factor. I. J Biol Chem. 269:1994;28130-28135.
32. 2 required the PH domain on ARNO. outstanding interest.
33. 2 were not noted. outstanding interest.
34. Liscovitch M, Cantley LC. Signal transduction and membrane traffic: the PITP/phosphoinositide connection. Cell. 81:1995;659-662 This review discusses a model involving roles for ARF, PLD and PIP 5-kinase in vesicle formation, uncoating and fusion. special interest.
35. +-selective channels gated by, inositol polyphosphates. J Biol Chem. 269:1994;17826-17832.
36. Prestwich GD, Dorman G, Elliott JT, Marecak DM, Chaudhary A. Benzophenone photoprobes for phosphoinositides, peptides and drugs. Photochem Photobiol. 65:1997;222-234.
37. Chen Y-G, Shields D. ADP-ribosylation factor-1 stimulates formation of nascent secretory vesicles from the trans-Golgi network of endocrine cells. J Biol Chem. 271:1996;5297-5300 See annotation [38]. special interest.
38. Dittie AS, Hajibagheri N, Tooze SA. The AP-1 adaptor complex binds to immature secretory granules from PC12 cells, and is regulated by ADP-ribosylation factor. J Cell Biol. 132:1996;523-536 These two papers [37,38] demonstrate the dependence of nascent secretory granules on ARF for their formation. The recruitment of AP-1 to immature granules in neuroendocrine cells is also dependent on ARF. special interest.
39. Seaman MNJ. Phospholipase D in vesicle budding. Trends Cell Biol. 6:1996;473.
40. Cavenagh MM, Whitney JA, Carroll K, Zhang C-J, Boman AL, Rosenwald AG, Mellman I, Kahn RA. Intracellular distribution of ARF proteins in mammalian cells. J Biol Chem. 271:1996;21767-21774 Antibodies to ARF1, ARF3, ARF4, ARF5 and ARF6 were used to determine the intracellular distribution of these proteins. ARF1, ARF3, ARF4 and ARF5 are cytosolic but are recruited to intracellular membranes (but not the plasma membrane) with GTPγS in a brefeldin A-sensitive manner. In contrast, ARF6 is stably associated with plasma membranes and its localization is insensitive to either GTPγS or brefeldin A. special interest.
41. Radhakrishna H, Klausner RD, Donaldson JG. Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase. J Cell Biol. 134:1996;935-947 Following up previous work, this study reports that ARF6 is localized to the plasma membrane and that its overexpression or activation induces the accumulation of endosomal intermediates that contain ARF6. special interest.
42. 2 production, which is required for secretion. special interest.
43. 2+ in permeable cells led to a loss of ARF6 from the granules. special interest.
44. 2. special interest.
45. Schafer DA, Jennings PB, Cooper JA. Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides. J Cell Biol. 135:1996;169-179.
46. Fukami K, Sawada N, Endo T, Takenawa T. Identification of a phosphatidylinositol 4,5-bisphosphate binding site in chicken skeletal muscle α-actinin. J Biol Chem. 271:1996;2646-2650.
47. 2 antibodies. outstanding interest.
48. Reif K, Nobes CD, Thomas G, Hall A, Cantrell DA. Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr Biol. 6:1996;1445-1455 A constitutively active PI 3-kinase was found to activate Rac-mediated lamellipodia and focal complex formation as well as Rho-mediated stress fiber and focal adhesion assemby. special interest.
49. 2 was demonstrated to be mediated through carboxy-terminal villin/gelsolin-like domains that are shared among Rho family GTPases. special interest.
50. Cerione RA, Zhang Y. The Dbl family of oncogenes. Curr Opin Cell Biol. 8:1996;216-222 A large number of proteins with Rho/Rac/Cdc42 guanine nucleotide exchange factor activity contain a Dbl oncogene domain and an adjacent PH domain. special interest.
51. Cross MJ, Roberts S, Ridley AJ, Hodgkin MN, Stewart A, Claesson-Welch L, Wakelam MJO. Stimulation of actin stress fibre formation mediated by activation of phospholipase D. Curr Biol. 6:1996;588-597 The authors report that PA formation is associated with cytoskeletal changes. special interest.
52. O'Sullivan AJ, Brown AM, Freeman HNM, Gomperts BD. Purification and identification of FOAD-II, a cytosolic protein that regulates secretion in steptolysin O-permeabilized mast cells, as a rac/rhoGDI complex. Mol Biol Cell. 7:1996;397-408 The authors purified a factor from brain cytosol that partially restored regulated secretion in permeable mast cells, which was identified as a Rac2 complex with RhoGDI, which, alone, has been reported to inhibit regulated secretion. special interest.
53. 2 stimulation of dynamin GTPase activity. special interest.
54. McPherson PS, Garcia EP, Slepnev VI, David C, Zhang X, Grabs D, Sossin WS, Bauerfeind R, Nemoto Y, De Camilli P. A presynaptic inositol-5-phosphatase. Nature. 379:1996;353-357 Characterization of a novel neuronal PPI 5-phosphatase. special interest.
55. Gaidarov I, Chen Q, Falck JR, Reddy KK, Keen JH. A functional phosphatidylinositol 3,4,5-trisphosphate/phosphoinositide binding domain in the clathrin adaptor AP-2 α subunit. J Biol Chem. 271:1996;20922-20929 See annotation [56]. special interest.
56. 6 in inhibiting AP-mediated clathrin lattice assembly. special interest.
57. Wiedemann C, Schafer T, Burger MM. Chromaffin granule-associated phosphatidylinositol 4-kinase activity is required for stimulated secretion. EMBO J. 15:1996;2094-2101.
58. Summers SA, Guebert BA, Shanahan MF. Polyphosphoinositide inclusion in artificial bilayer vesicles promotes divalent cation-dependent membrane fusion. Biophys J. 71:1996;3199-3206.
59. Chemomordik L. Non-bilayer lipids and biological fusion intermediates. Chem Phys Lipids. 81:1996;203-213.
60. 2+. special interest.
61. Fukuda M, Moreira JE, Lewis FMT, Sugimori M, Niinobe M, Mikoshiba K, Llinas R. Role of the C2B domain of synaptotagmin in vesicular release and recycling as determined by specific antibody injection into the squid giant synapse preterminal. Proc Natl Acad Sci USA. 92:1995;10708-10712 See annotation [62]. of special interest outstanding interest.
62. 6 to synaptotagmin 1 is suggested by the ability of synaptotagmin C2B-specific antibodies to prevent inhibition. Similar results are described in [62] for studies of secretion in permeable adrenal cells. of outstanding interest special interest.