A novel retinoid-related molecule inhibits pancreatic cancer cell proliferation by a retinoid receptor independent mechanism via suppression of cell cycle regulatory protein function and induction of caspase-associated apoptosis

Oncogene

Volumn 24, Issue 26, 2005, Pages 4257-4270

  Balasubramanian, Sivaprakasam ^a   Chandraratna, Roshantha A S ^b   Eckert, Richard L ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ALLERGAN INC   (United States)

Author keywords

AGN193198; Apoptosis; Caspases; Cell cycle; Pancreatic cancer; Retinoids

Indexed keywords

[4 [3 (1 HEPTYL 4,4 DIMETHYL 2 OXO 1,2,3,4 TETRAHYDROQUINOLIN 6 YL) 3 OXO PROPHENYL] BENZOIC ACID]; AGN 193198; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN A; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN E; INTERLEUKIN 2 RECEPTOR ALPHA; PROTEIN P21; PROTEIN P27; RETINOID; RETINOID RECEPTOR; RETINOID X RECEPTOR; UNCLASSIFIED DRUG; AGN193198; CASPASE; CELL CYCLE PROTEIN; QUINOLINE DERIVATIVE; RETINOIC ACID RECEPTOR;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL FUNCTION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DRUG ACTIVITY; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR AFFINITY; TRANSCRIPTION REGULATION; CELL CULTURE; GENETIC TRANSCRIPTION; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGY;

AGOUTI PACA;

APOPTOSIS; CASPASES; CELL CYCLE; CELL CYCLE PROTEINS; CELL PROLIFERATION; HUMANS; PANCREATIC NEOPLASMS; QUINOLINES; RECEPTORS, RETINOIC ACID; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 20544453508     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208586     Document Type: Article

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