Induction of apoptosis by fenretinide (4HPR) in human ovarian carcinoma cells and its association with retinoic acid receptor expression

International Journal of Cancer

Volumn 65, Issue 4, 1996, Pages 491-497

  Supino, Rosanna ^a   Crosti, Mariacristina ^a   Clerici, Monica ^a   Warlters, Andrea ^a   Cleris, Loredana ^a   Zunino, Franco ^a   Formelli, Franca ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; FENRETINIDE; RETINOIC ACID; RETINOIC ACID RECEPTOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG POTENTIATION; DRUG SENSITIVITY; FEMALE; HUMAN; HUMAN CELL; OVARY CARCINOMA; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL DIVISION; CISPLATIN; FEMALE; FENRETINIDE; HUMANS; OVARIAN NEOPLASMS; RECEPTORS, RETINOIC ACID; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0029868250     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960208)65:4<491::AID-IJC17>3.0.CO;2-D     Document Type: Article

References (33)

1. BISSONETTE, R.P., ECHEVERRI, F., MAHBOUBI, A. and GREEN, D.R., Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature (Lond.), 359, 552-554, (1992).
2. CALIARO, M.J., MERMOUGEI, C., GUICRARD, S., MAZARS, PH., VALETTE, A., MOISAND, A., BUGAT, R. and JOZAN, S., Response of four human ovarian carcinoma cell lines to all-trans retinoic acid: relationship with induction of differentiation and retinoic acid receptor expression. Int. J. Cancer, 56, 743-748 (1994).
3. CHIRGWIN, J.M., PRZYBYLA, A.E., MACDONALD, R.J. and RUTTER, W.J., Isolation of biologically active ribonucleic acids from sources enriched in ribonuclease. Biochemistry, 18, 5294-5299 (1979).
4. COSTA, A., FORMELLI, F., CHIESA, F., DECENSI, A., DE PALO, G. and VERONESI, U., Prospects of chemoprevention of human cancers with the synthetic retinoid fenretinide. Cancer Res., 54, 2032s-2037s (1994).
5. DELIA, D., AIELLO, A., FORMELLI, F., FONTANELLA, E., COSTA, A., MIVASHITA, T., REED, J.C. and PIEROTTI, M.A., Regulation of apoptosis induced by the retinoid N-(4-hydroxyphenyl) retinamide and effect of deregulated bcl-2. Blood. 85, 359-367 (1995).
6. DELIA, D., AIELLO, A., LOMBARDI, L., PELICCI, P.G., GRIGNANI, F., GRIGNANI, F., FORMELLI, F., MENARD, S., COSTA, A., VERONESI, U. and PIEROTTI, M.A., N-(4-hydroxyphenyl)retinamide induces appptosis of malignant hemopoietic cell lines including those unresponsive to retinoic acid. Cancer Res., 53, 6036-6041 (1993).
7. DE PALO, G., VERONESI, U., CAMERINI, T., FORMELLI, F., MASCOTTI, G., BONI, C., FOSSER, V., DEL VECCHIO, M., CAMPA, T., COSTA, A. and MARUBINI, E., Can fenretinide protect women against ovarian cancer? J. nat. Cancer Inst., 87, 146-147 (1995).
8. DERMIME, B.S., GRIGNANI, F., CLERICI, M., NERVI, C., SOZZI, G., TALAMO, G.P., MARCHESI, E., FORMELLI, F., PARMIANI, G., PELICCI, P.G. and GAMBACORTI-PASSERINI, C., Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the pml/RARα protein. Blood. 82, 1573-1577 (1993).
9. DE THE, H., MARCHIO, A., TIOLLAIS, P. and DEJEAN, A., Differential expression and ligand regulation of the retinoic acid receptor α and β genes. EMBO J., 8, 429-433 (1989).
10. DI VINCI, A., GEIDO, E., INFUSINI, E. and GIARETTI, W., Neuroblastoma cell apoptosis induced by the synthetic retinoid N-(4-hydroxyphenyl)retinamide. Int. J. Cancer, 59, 422-426 (1994).
11. DREWINKO, B., LOO, T.L., BROWN, B., GOTTLIEB, J.A. and FREIREICH, E.J., Combination chemotherapy in vitro with adriamycin. Observation of additive, antagonistic, and synergistic effects when used in two-drug combinations on cultured human lymphoma cells. Cancer Biochem. Biophys., 1, 187-195 (1976).
12. FORMELLI, F., CARSANA, R., COSTA, A., BURANELLI, F., CAMPA, T. DOSSENA, G., MAGNI, A. and PIZZICHETTA, M., Plasma retinol level reduction by the synthetic retinoid fenretinide: a one year follow-up study of breast cancer patients. Cancer Res., 48, 6149-6152 (1989).
13. FORMELLI, F., CLERICI, M., CAMPA, T., DI MAURO, M.G., MAGNI, A., MASCOTTI, G., MOGLIA, D., DE PALO, G., COSTA, A. and VERONESI, U., Five year administration of fenretinide: pharmacokinetics and effects on plasma retinol concentrations. J. clin. Oncol., 11, 2036-2042 (1993).
14. FORMELLI, F. and CLERIS, L., Synthetic retinoid fenretinide is effective against a human ovarian carcinoma xenograft and potentiates cisplatin activity. Cancer Res., 53, 5374-5376 (1993).
15. GARCLA-MARTINEZ, V., MACIAS, D., GANAN, Y., GARCIA-LOBO, J.M., FRANCIA, M.V., FERNANDEZ-TERAN, M.A. and HURLE, J.M., Internucleosomal DNA fragmentation and programmed cell death (apoptosis) in the interdigital tissue of the embryonic chick leg bud. J. Cell Sci., 106, 201-208 (1993).
16. GUCHELAAR, H.-J., TIMMER-BOSSCHA, H., DAM-MEIRING, A., UGES, D.R.A., OOSTERHUIS, J.W., DE VRIES, E.G.E, and MULDER, N.H., Enhancement of cisplatin and etoposide cytotoxicity after all-trans retinoic-acid-induced cellular differentiation of a murine embryonal carcinoma cell line. Int. J. Cancer, 55, 442-447 (1993).
17. GUDAS, L.J., Retinoids, retinoid-responsive genes, cell differentiation and cancer. Cell Growth Differ., 3, 655-662 (1992).
18. HARANT, H., KORSCHINECK, I., KRUPITZA, G., FAZENY, B., DITTRICH, C. and GRUNT, T.W., Retinoic acid receptors in retinoid responsive ovarian cancer cell lines detected by polymerase chain reaction following reverse transcription. Brit. J. Cancer, 68, 530-536 (1993).
19. HAVRILESKY, L.J., HURTEAU, J.A., WHITAKER, R.S., ELBENDARY, A., WU, S., RODRIGUEZ, G.C., BAST, R.C. and BERCHUCK, A., Regulation of apoptosis in normal and malignant ovarian epithelial cells by transforming growth factor β1. Cancer Res., 55, 944-948 (1995).
20. HOULE, B., ROCHETTE-EGLY, C. and BRADLEY, W.E.C., Tumor-suppressive effect of the retinoic acid receptor β in human epidermoid lung cancer cells. Proc. nat. Acad. Sci. (Wash.), 90, 985-989 (1993).
21. IGAWA, M., TANABE, T., CHODAK, G.W. and RUKSTALIS, D.B., N-(4-hydroxyphenyl)retinamide induces cell cycle specific growth inhibition in PC3 cells. Prostate, 24, 299-305 (1994).
22. LEARY, J.A., DORIS, C.P., BOLTZ, E.M., HOUGHTON, C.R.S., KEFFORD, R.F. and FRIEDLANDER, M.L., Investigation of loss of heterozygosity at specific loci on chromosomes 3p, 6q, 11p, 17p and 17q in ovarian cancer. Int. J. Gynecol. Cancer, 3, 293-298 (1993).
23. LOTAN, R., XU, X.-C., LIPPMAN, S.M., RO, J.Y., EE, J.S., LEE, J.J. and HONG, W.K., Suppression of retinoic acid receptor-β in premalignant oral lesions and its up-regulation by isotretinoin. New Engl. J. Med., 332, 1405-1410 (1995).
24. MOON, R.C., MEHTA, R.G. and RAO, K.V.N., Retinoids and cancer in experimental animals. In: M.B. Sporn, A.B. Roberts and D.S. Goodman (eds.), The retinoids: biology, chemistry, and medicine (2nd ed.), p. 573-595, Raven Press, New York (1994).
25. MOON, R.C., THOMPSON, H.J., BECCI, P.J., GRUBBS, C.H., GANDER, R.J., NEWTON, D.L., SMITH, J.M., PHILLIPS, S.L., HENDERSON, W.R., MULLEN, L.T., BROWN, C.C. and SPORN, M.B., N-(4-hydroxyphenyl)retinamide, a new retinoid for prevention of breast cancer in the rat. Cancer Res., 39, 1339-1346 (1979).
26. PALUMBO, A. and YEH, J., In situ localization of apoptosis in the rat ovary during follicular atresia. Biol. Reprod., 51, 888-895 (1994).
27. PELLEGRINI, R. and 12 OTHERS, Modulation of markers associated with tumor aggressiveness in human breast cancer cell lines by N-(4-hydroxyphenyl)retinamide. Cell Growth Differ., 6, (1995) 863-869.
28. PEMRICK, S.M., LUCAS, D.A. and GRIPPO, J.F., The retinoid receptors. Leukemia, 8, 1797-1806 (1994).
29. PONZONI, M., BOCCA, P., CHIESA, V., DECENSI, A., PISTOIA, V., RAFFAGHELLO, L., Rozzo, C. and MONTALDO, P.G., Differential effects of N-(4-hydroxyphenyl)retinamide and retinoic acid on neuroblastoma cells: apoptosis versus differentiation. Cancer Res., 55, 853-861 (1995).
30. ROTMENSZ, N. and 19 OTHERS, Long term tolerability of fenretinide (4-HPR) in breast cancer patients. Europ. J. Cancer, 27, 1127-1131 (1991).
31. SPORN, M.B. and ROBERTS, A.B., Interactions of retinoids and transforming growth factor-β in regulation of cell differentiation and proliferation. Mol. Endocrinol, 5, 3-7 (1991).
32. SWISSHELM, K., RYAN, K., LEE, X., TSOU, H.C., PEACOCKE, M. and SAGER, R., Down-regulation of retinoic acid receptor β in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells. Cell Growth Differ., 5, 133-141 (1994).
33. XIA, C., TAYLOR, J.B., SPENCER, S.R. and KETTERER, B., The human glutathione S-transferase P1-1 gene: modulation of expression by retinoic acid and insulin. Biochem. J., 292, 845-850 (1993).