Mutations within an intramembrane leucine heptad repeat disrupt oligomer formation of the rat GABA transporter 1

Journal of Biological Chemistry

Volumn 277, Issue 46, 2002, Pages 43682-43690

  Scholze, Petra ^a   Freissmuth, Michael ^a   Sitte, Harald H ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; BIOSYNTHESIS; CELL MEMBRANES; DIMERIZATION; MICROSCOPIC EXAMINATION; OLIGOMERS; PROTEINS;

MEMBRANE VESICLES;

MUTAGENESIS;

4 AMINOBUTYRIC ACID TRANSPORTER 1; ALANINE; CARRIER PROTEIN; LEUCINE; OLIGOMER; PROTEIN KINASE C; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BIOSYNTHESIS; CELL MEMBRANE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENERGY TRANSFER; ENZYME REGULATION; ENZYME SUBSTRATE COMPLEX; GABAERGIC SYSTEM; HUMAN; HUMAN CELL; MUTATION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT;

AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CELL LINE; CELL MEMBRANE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; HUMANS; KINETICS; LEUCINE; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; ORGANIC ANION TRANSPORTERS; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; RATS; SUBSTRATE SPECIFICITY; TIME FACTORS; TRANSFECTION;

ANIMALIA;

EID: 0037113887     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205602200     Document Type: Article

References (50)

1. Rudnick, G., and Clark, J. (1993) Biochim. Biophys. Acta 1144, 249-263
2. Axelrod, J., Whitby, L. G., and Hertting, G. (1961) Science 133, 383-384
3. Iversen, L. (2000) Mol. Psychiatry 5, 357-362
4. Levi, G., and Raiteri, M. (1993) Trends Neurosci. 16, 415-419
5. Klingenberg, M. (1981) Nature 290, 449-454
6. Veenhoff, L. M., Heuberger, E. H., and Poolman, B. (2002) Trends Biochem. Sci. 27, 242-249
7. Schmid, J. A., Scholze, P., Kudlacek, O., Freissmuth, M., Singer, E. A., and Sitte, H. H. (2001) J. Biol. Chem. 276, 3805-3810
8. Jess, U., Betz, H., and Schloss, P. (1996) FEBS Lett. 394, 44-46
9. Kilic, F., and Rudnick, G. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 3106-3111
10. Hastrup, H., Karlin, A., and Javitch, J. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 10055-10060
11. Eskandari, S., Kreman, M., Kavanaugh, M. P., Wright, E. M., and Zampighi, G. A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 8641-8646
12. Sonders, M. S., and Amara, S. G. (1996) Curr. Opin. Neurobiol. 6, 294-302
13. DeFelice, L. J., and Blakely, R. D. (1996) Biophys. J. 70, 579-580
14. Beckman, M. L., and Quick, M. W. (1998) J. Membr. Biol. 164, 1-10
15. Cammack, J. N., and Schwartz, E. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 723-727
16. Risso, S., DeFelice, L. J., and Blakely, R. D. (1996) J. Physiol. (Lond.) 490, 691-702
17. Lu, C. C., and Hilgemann, D. W. (1999) J. Gen. Physiol. 114, 445-457
18. Lu, C. C., and Hilgemann, D. W. (1999) J. Gen. Physiol. 114, 429-444
19. Hilgemann, D. W., and Lu, C. C. (1999) J. Gen. Physiol. 114, 459-475
20. Jentsch, T. J. (2002) Nature 415, 276-277
21. O'Shea, E. K., Rutkowski, R., Stafford, W. F., III, and Kim, P. S. (1989) Science 245, 646-648
22. Bartkiewicz, M., Houghton, A., and Baron, R. (1999) J. Biol. Chem. 274, 30887-30895
23. Su, H. P., Brugnera, E., Van Criekinge, W., Smits, E., Hengartner, M., Bogaert, T., and Ravichandran, K. S. (2000) J. Biol. Chem. 275, 9542-9549
24. Bauer, M. F., Sirrenberg, C., Neupert, W., and Brunner, M. (1996) Cell 87, 33-41
25. Sato, K., Betz, H., and Schloss, P. (1995) FEBS Lett. 375, 99-102
26. Sitte, H. H., Singer, E. A., and Scholze, P. (2002) Br. J. Pharmacol. 135, 93-102
27. Fleming, K. G., and Engelman, D. M. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 14340-14344
28. McCormack, K., Tanouye, M. A., Iverson, L. E., Lin, J. W., Ramaswami, M., McCormack, T., Campanelli, J. T., Mathew, M. K. and Rudy, B. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 2931-2935
29. Garcia, J., Nakai, J., Imoto, K., and Beam, K. G. (1997) Biophys. J. 72, 2515-2523
30. Beckman, M. L., Bernstein, E. M., and Quick, M. W. (1998) J. Neurosci. 18, 6103-6112
31. Beckman, M. L., Bernstein, E. M., and Quick, M. W. (1999) J. Neurosci. 19, RC9(1-6)
32. Zahniser, N. R., and Doolen, S. (2001) Pharmacol. Ther. 92, 21-55
33. Gadella, T. W., Jr., and Jovin, T. M. (1995) J. Cell Biol. 129, 1543-1558
34. Rocheville, M., Lange, D. C., Kumar, U., Sasi, R., Patel, R. C., and Patel, Y. C. (2000) J. Biol. Chem. 275, 7862-7869
35. Scholze, P., Norregaard, L., Singer, E. A., Freissmuth, M., Gether, U., and Sitte, H. H. (2002) J. Biol. Chem. 277, 21505-21513
36. Arkin, I. T., Adams, P. D., MacKenzie, K. R., Lemmon, M. A., Brunger, A. T., and Engelman, D. M. (1994) EMBO J. 13, 4757-4764
37. Cornea, R. L., Autry, J. M., Chen, Z., and Jones, L. R. (2000) J. Biol. Chem. 275, 41487-41494
38. Gurezka, R., Laage, R., Brosig, B., and Langosch, D. (1999) J. Biol. Chem. 274, 9265-9270
39. Choma, C., Gratkowski, H., Lear, J. D., and DeGrado, W. F. (2000) Nat. Struct. Biol. 7, 161-166
40. Zhou, F. X., Merianos, H. J., Brunger, A. T., and Engelman, D. M. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 2250-2255
41. Zhou, F. X., Cocco, M. J., Russ, W. P., Brunger, A. T., and Engelman, D. M. (2000) Nat. Struct. Biol. 7, 154-160
42. Weiner, D. B., Liu, J., Cohen, J. A., Williams, W. V., and Greene, M. I. (1989) Nature 339, 230-231
43. Bargmann, C. I., and Weinberg, R. A. (1988) EMBO J. 7, 2043-2052
44. Asano, T., Takata, K., Katagiri, H., Tsukuda, K., Lin, J. L., Ishihara, H., Inukai, K., Hirano, H., Yazaki, Y., and Oka, Y. (1992) J. Biol. Chem. 267, 19636-19641
45. Quick, M. W. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 5686-5691
46. Mabjeesh, N. J., and Kanner, B. I. (1992) J. Biol. Chem. 267, 2563-2568
47. Bendahan, A., and Kanner, B. I. (1993) FEBS Lett. 318, 41-44
48. Perego, C., Bulbarelli, A., Longhi, R., Caimi, M., Villa, A., Caplan, M. J., and Pietrini, G. (1997) J. Biol. Chem. 272, 6584-6592
49. Förster, T. (1948) Ann. d. Physik (Leipzig) 2, 57-75
50. Wilson, M. C., Meredith, D., and Halestrap, A. P. (2002) J. Biol. Chem. 277, 3666-3672