Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels

Journal of Physiology

Volumn 557, Issue 2, 2004, Pages 489-500

  Martina, Marzia ^a   Gorfinkel, Yelena ^a   Halman, Samantha ^a   Lowe, John A ^b   Periyalwar, Pranav ^a   Schmidt, Christopher J ^b   Bergeron, Richard ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSPORTER; CP 802079; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN INHIBITOR; SARCOSINE; UNCLASSIFIED DRUG; CP 802,079; GLUTAMIC ACID; GLYCINE RECEPTOR ANTAGONIST; GLYCINE TRANSPORTER 1;

ANIMAL CELL; ARTICLE; BRAIN SLICE; CONCENTRATION (PARAMETERS); DRUG MECHANISM; DRUG RECEPTOR BINDING; EVOKED RESPONSE; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; PATCH CLAMP; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; CONCENTRATION RESPONSE; EXTRACELLULAR GLYCINE LEVEL; HIPPOCAMPAL CA1 REGION; INTERNALIZATION; MICRODIALYSIS; PROTEIN FUNCTION; REVERSE MICRODIALYSIS; SYNAPSE; SYNAPTIC CLEFT; WHOLE CELL PATCH CLAMP;

ACETIC ACIDS; AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; ANIMALS; GLYCINE; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; PATCH-CLAMP TECHNIQUES; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SARCOSINE; THIAZOLES;

EID: 3042542923     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2004.063321     Document Type: Article

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